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中文名稱:兔子基質金屬蛋白酶3(MMP-3)酶聯免疫試劑盒
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貨號:CSB-E09269Rb
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規格:96T/48T
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價格:¥4200/¥3000
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其他:
產品詳情
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產品描述:兔子基質金屬蛋白酶3(MMP-3)酶聯免疫試劑盒(CSB-E09269Rb)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的MMP3含量。MMP3 即基質金屬蛋白酶 3,它在細胞外基質的降解和重塑等生理過程中發揮重要作用。其異常表達與腫瘤侵襲轉移、關節炎等疾病發展密切相關。研究機制主要聚焦于其對基質成分的作用、信號通路的影響等,為相關疾病治療提供靶點思路。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL,適用于體外培養細胞、動物模型組織等科研場景中MMP-3的動態監測,為研究結締組織代謝調控、炎癥性疾病機制及藥物干預效果提供可靠工具本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:MMP3 ELISA Kit; Stromelysin-1 ELISA Kit; SL-1 ELISA Kit; EC 3.4.24.17 ELISA Kit; Matrix metalloproteinase-3 ELISA Kit; MMP-3 ELISA Kit; Transin-1 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Oryctolagus cuniculus (Rabbit)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:0.156 ng/mL-10 ng/mL
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靈敏度:0.039 ng/mL
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Cancer
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of rabbit MMP-3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:5 Average % 84 Range % 80-94 1:10 Average % 97 Range % 91-105 1:20 Average % 93 Range % 85-97 1:40 Average % 94 Range % 86-99 -
回收率:
The recovery of rabbit MMP-3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 96 89-98 EDTA plasma (n=4) 89 85-96 -
標準曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. ng/ml OD1 OD2 Average Corrected 10 2.794 2.694 2.744 2.593 5 2.244 2.144 2.194 2.043 2.5 1.424 1.324 1.374 1.223 1.25 0.854 0.824 0.839 0.688 0.625 0.546 0.536 0.541 0.390 0.312 0.361 0.351 0.356 0.205 0.156 0.230 0.220 0.225 0.074 0 0.152 0.149 0.151 -
數據處理:
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貨期:3-5 working days
引用文獻
相關產品
靶點詳情
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功能:Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
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基因功能參考文獻:
- Compromised autophagy may be related to the osteoarthritis progression; JNK and p38 MAPKs up-regulate MMP3 and down-regulate autophagy. PMID: 26873249
- the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts. PMID: 23879595
- chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage. PMID: 23520014
- Ulinastatin effectively inhibited the increased expression of MMP-2, MMP-3, and iNOS in degenerated NP cells induced by IL-1beta in vitro. PMID: 22853554
- Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases. PMID: 20238014
- Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits. PMID: 19778818
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亞細胞定位:Secreted, extracellular space, extracellular matrix.
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蛋白家族:Peptidase M10A family
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數據庫鏈接:
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