在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse γ-Secretase ELISA kit

Mouse γ-Secretase ELISA kit

  • 中文名稱：
    小鼠γ分泌酶酶聯免疫試劑盒
  • 貨號：
    CSB-E12142m
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠γ分泌酶酶聯免疫試劑盒（CSB-E12142m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的APH1B含量。APH1B 是一種重要靶點。它在γ-分泌酶復合物中起關鍵作用。研究發現其與阿爾茨海默病等神經退行性疾病機制相關，可能參與調節淀粉樣蛋白生成。目前圍繞它探索新治療策略，深入了解其作用機制或為相關疾病防治帶來新思路。試劑盒檢測范圍為7.8 pg/mL-500 pg/mL，適用于腦組織樣本分析、疾病模型構建、神經退行機制探究等科研領域，可支持藥物開發中酶活性抑制劑的功效評估、轉基因動物模型驗證及病理狀態下γ分泌酶表達水平動態監測等實驗需求，為探索γ分泌酶在細胞信號傳導和疾病發生中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Aph1b; Gamma-secretase subunit APH-1B; APH-1b; Aph-1beta
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse γ-Secretase in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %96
    Range %90-102
    1:2Average %102
    Range %97-107
    1:4Average %89
    Range %87-93
    1:8Average %94
    Range %90-98
  • 回收率：
    The recovery of mouse γ-Secretase spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10399-106
    EDTA plasma (n=4)9589-102
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    5002.234 2.356 2.295 2.130
    2501.367 1.378 1.373 1.208
    1250.810 0.824 0.817 0.652
    62.50.492 0.452 0.472 0.307
    31.20.313 0.306 0.310 0.145
    15.60.236 0.250 0.243 0.078
    7.80.205 0.209 0.207 0.042
    00.160 0.169 0.165
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • 基因功能參考文獻：
    1. Loss of Aph1B is associated with memory deficit. PMID: 26942869
    2. Prostaglandin I2 accumulation in neuronal cells activates PKA/CREB and JNK/c-Jun signaling pathways by phosphorylation, which results in APH-1alpha/1beta expression. PMID: 27240539
    3. Abeta oligomers in the cerebrospinal fluid (CSF) further promoted the expression of APH-1alpha/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP and Abeta deposition during AD progression PMID: 26293690
    4. analysis of hippocampal circuitry via Aph1b-gamma-secretase/neuregulin 1 signalling PMID: 24891237
    5. Upregulation of PS1/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease. PMID: 22140537
    6. study shows gamma-secretase complexes containing different Aph1 subunits have heterogeneous properties; inactivation of Aph1B gamma-secretase in an Alzheimer disease model led to improvement of disease-relevant features without Notch-related side effects PMID: 19299585

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    APH-1 family
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲伊人情人综合网站| 国产98色在线 | 国| 草草影院精品一区二区三区| 国产亚洲精品久久久999蜜臀| 蜜臀av性久久久久蜜臀aⅴ | 国产美女遭强高潮网站下载| 四川丰满少妇被弄到高潮| 久久久亚洲欧洲日产国产成人无码| 午夜视频无码国产在线观看| 国产美熟女乱又伦av果冻传媒 | 纯肉无遮挡无码日本动漫| 欧美大片欧美激情性色a∨在线| 国产日产久久高清欧美一区| 国产成a人片在线观看视频下载| 午夜亚洲www湿好大| 思思久久精品一本到99热| 成视频年人黄网站免费视频| 国产在线观看码高清视频| 亚洲国产午夜精华无码福利 | 国产精品天干天干有线观看| 在线亚洲视频网站www色| 国产成人亚洲综合色婷婷秒播 | 天堂√在线中文最新版| 免费观看黄网站| 无码人妻精品一区二区三区久久久| 国产欧美日韩视频怡春院| 亚洲精品伊人久久久大香| 风间由美性色一区二区三区| 亚洲国产精品综合久久网各| 中日韩精品无码一区二区三区| 99热精国产这里只有精品| 搡8o老女人老妇人老熟| 最新国产精品拍自在线观看| 18禁真人抽搐一进一出免费| 色婷婷欧美在线播放内射| 人妻在客厅被c的呻吟| 亚洲人成网站18禁止大| 亚洲男同gv在线观看| 国产精品自在在线午夜出白浆| 国产成人mv视频在线观看| 亚洲旡码欧美大片|