在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse γ-Secretase ELISA kit

Mouse γ-Secretase ELISA kit

  • 中文名稱：
    小鼠γ分泌酶酶聯免疫試劑盒
  • 貨號：
    CSB-E12142m
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠γ分泌酶酶聯免疫試劑盒（CSB-E12142m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的APH1B含量。APH1B 是一種重要靶點。它在γ-分泌酶復合物中起關鍵作用。研究發現其與阿爾茨海默病等神經退行性疾病機制相關，可能參與調節淀粉樣蛋白生成。目前圍繞它探索新治療策略，深入了解其作用機制或為相關疾病防治帶來新思路。試劑盒檢測范圍為7.8 pg/mL-500 pg/mL，適用于腦組織樣本分析、疾病模型構建、神經退行機制探究等科研領域，可支持藥物開發中酶活性抑制劑的功效評估、轉基因動物模型驗證及病理狀態下γ分泌酶表達水平動態監測等實驗需求，為探索γ分泌酶在細胞信號傳導和疾病發生中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Aph1b; Gamma-secretase subunit APH-1B; APH-1b; Aph-1beta
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse γ-Secretase in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %96
    Range %90-102
    1:2Average %102
    Range %97-107
    1:4Average %89
    Range %87-93
    1:8Average %94
    Range %90-98
  • 回收率：
    The recovery of mouse γ-Secretase spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10399-106
    EDTA plasma (n=4)9589-102
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    5002.234 2.356 2.295 2.130
    2501.367 1.378 1.373 1.208
    1250.810 0.824 0.817 0.652
    62.50.492 0.452 0.472 0.307
    31.20.313 0.306 0.310 0.145
    15.60.236 0.250 0.243 0.078
    7.80.205 0.209 0.207 0.042
    00.160 0.169 0.165
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • 基因功能參考文獻：
    1. Loss of Aph1B is associated with memory deficit. PMID: 26942869
    2. Prostaglandin I2 accumulation in neuronal cells activates PKA/CREB and JNK/c-Jun signaling pathways by phosphorylation, which results in APH-1alpha/1beta expression. PMID: 27240539
    3. Abeta oligomers in the cerebrospinal fluid (CSF) further promoted the expression of APH-1alpha/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP and Abeta deposition during AD progression PMID: 26293690
    4. analysis of hippocampal circuitry via Aph1b-gamma-secretase/neuregulin 1 signalling PMID: 24891237
    5. Upregulation of PS1/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease. PMID: 22140537
    6. study shows gamma-secretase complexes containing different Aph1 subunits have heterogeneous properties; inactivation of Aph1B gamma-secretase in an Alzheimer disease model led to improvement of disease-relevant features without Notch-related side effects PMID: 19299585

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    APH-1 family
  • 數據庫鏈接：


主站蜘蛛池模板： 成人国产精品一区二区免费看| 国产精品女主播主要上线| 国产熟妇人妻精品一区二区动漫| 成人无码av一区二区| 国产女人被狂躁到高潮小说| 麻豆av传媒蜜桃天美传媒| 亚洲成av人片天堂网老年人| 国产99视频精品免费视看6| 国产精欧美一区二区三区| 黄页网站视频| 日本一卡2卡三卡4卡免费网站| 午夜尤物禁止18点击进入| 日本高清色本在线www| 免费做爰猛烈吃奶摸视频在线观看 | 久久这里只精品国产免费9| 五十路熟妇强烈无码| 国产精品v片在线观看不卡 | 大地资源中文在线观看官网第二页| 国产av成人一区二区三区| 国模无码人体一区二区| 国产免费人成在线视频app| 亚洲精品国产一区二区的区别| 亚洲va中文字幕| 亚洲欧美日韩综合在线一| 亚洲婷婷开心色四房播播| 久久经精品久久精品免费观看| 中文字幕亚洲无线码在线一区| 久久久中文字幕日本无吗| 99久久亚洲综合精品成人| 国产成人精品无码免费看| 国产精品特级毛片一区二区三区| 亚洲图片自拍偷图区| 久久国产色欲av38| 好男人社区www在线观看| 成人免费的视频| 国产日产欧产精品精品免费| 亚洲乱码日产精品bd在观看| 成人综合伊人五月婷久久| 在线播放国产不卡免费视频| 春色校园亚洲愉拍自拍| 国产亚洲精品精品精品|