在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Mouse soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA KIT

  • 中文名稱:
    小鼠可溶性腫瘤壞死因子相關凋亡誘導配體(sTRAIL)酶聯免疫試劑盒
  • 貨號:
    CSB-E07371m
  • 規格:
    96T/48T
  • 價格:
    ¥3200/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠可溶性腫瘤壞死因子相關凋亡誘導配體(sTRAIL)酶聯免疫試劑盒(CSB-E07371m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的TNFSF10含量。TNFSF10,即腫瘤壞死因子超家族成員10,其背景上作為細胞因子參與機體免疫等多種生理過程。研究機制方面,它可與特定受體結合,激活細胞內信號通路,誘導腫瘤細胞凋亡,在抗腫瘤研究領域是備受關注的潛在靶點。試劑盒檢測范圍為31.25 pg/ml- 2000pg/ml,適用于體外實驗環境下探究sTRAIL在腫瘤生物學、免疫調控機制中的功能解析,或用于評估藥物干預、基因修飾等處理對sTRAIL表達水平的影響。為相關基礎研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Tnfsf10 ELISA Kit; Trail ELISA Kit; Tumor necrosis factor ligand superfamily member 10 ELISA Kit; TNF-related apoptosis-inducing ligand ELISA Kit; Protein TRAIL ELISA Kit; CD antigen CD253 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    31.25 pg/ml - 2000pg/ml
  • 靈敏度:
    7.8 pg/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cell Biology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
  • 基因功能參考文獻:
    1. TRAIL protects against insulin resistance, NAFLD and vascular inflammation. Increasing TRAIL levels may be an attractive therapeutic strategy, to reduce features of diabetes, as well as liver and vascular injury, so commonly observed in individuals with NAFLD. PMID: 28507343
    2. Isolated highly-pure population of DcR2-positive renal tubular epithelial cells was isolated by MACS, which was confirmed to comprise of active senescent RTECs based on the cell cycle phase. PMID: 28461078
    3. Data suggest that the CXCL9-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice. PMID: 29088306
    4. this study shows pathogenic role for TRAIL in chronic obstructive pulmonary disease PMID: 26555706
    5. pCLE results indicated that endomicroscopy could effectively quantify injected MSCs that homed to subcutaneous xenograft tumor sites in vivo and correlated well with the therapeutic effects of the TRAIL gene PMID: 27617958
    6. the aim of this study is to elucidate the role of TRAIL during rhinovirus (RV) infection in vivo. PMID: 27836899
    7. Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation. PMID: 27742702
    8. Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio. PMID: 28070143
    9. Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.( PMID: 26935795
    10. TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4/eNOS/nitric oxide signaling. PMID: 26572549
    11. PARP1 acts as a prominent upstream regulator of high mobility group box 1-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance PMID: 25607248
    12. Data suggest that Socs3 (suppressor of cytokine signaling 3) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase/AP-1 transcription factor signaling. PMID: 25827060
    13. These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70. PMID: 25356750
    14. These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald burns PMID: 25031778
    15. TRAIL-deficiency in ApoE(-/-) mice exacerbates nephropathy and insulin resistance PMID: 24667560
    16. TRAIL induces apoptosis in tissue-infiltrating neutrophils thereby protecting organs from sepsis-induced injury. PMID: 24887152
    17. Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease. PMID: 24045576
    18. These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity. PMID: 24097299
    19. expression of TRAIL on natural killer cells is protective in a murine model of hepatic ischemia-reperfusion injury through modulation of natural killer cell cytotoxicity and NK cell differentiation PMID: 24804996
    20. TRAIL signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation PMID: 24509861
    21. The extracellular domain of Fn14 fused to the extracellular domain of the TRAIL ligand is designed to modulate the immune system as an anti-inflammatory agent. PMID: 23497038
    22. oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer PMID: 23408429
    23. Data indicate that TNF-related apoptosis-inducing ligand knockout mice (TRAIL -/-) showed significantly decreased lung bacterial clearance and survival in response to Streptococcus pneumoniae. PMID: 23071253
    24. Data indicate the importance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in pulmonary arterial hypertension (PAH) pathogenesis and suggest its potential as a therapeutic target to direct future translational therapies PMID: 23071256
    25. data demonstrate that TRAIL induces osteoclastic differentiation via a TRAF-6 dependent signaling pathway PMID: 22719861
    26. CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons. PMID: 22740407
    27. findings shed light on the possible anti-adipogenic and anti-inflammatory effects of TRAIL and open new therapeutic possibilities against obesity, systemic inflammation and T2DM PMID: 22616837
    28. Epirubicin enhances the antiarthritic effect of rAAV2/5-TRAIL and that combination treatment might be an important therapeutic alternative, with practical significance for rheumatoid arthritis. PMID: 22131069
    29. It was shown for the first time that TRAIL deficiency promotes numerous features of diabetes typical of human disease, and are associated with reduced insulin and pancreatic inflammation/apoptosis. PMID: 21965021
    30. TRAIL strongly synergizes with APAP in inducing cell death in hepatocyte-like cells lines and primary hepatocyte. PMID: 21654829
    31. the tumoricidal activity of CnB-activated peritoneal macrophages is partially dependent on TRAIL. PMID: 22116828
    32. TRAIL regulates the magnitude of the influenza A virus (IAV)-specific CD8 T cell response during a clinically significant IAV infection to decrease the chance for infection-induced immunopathology. PMID: 21940678
    33. TRAIL-deficient mice had an enhanced inflammatory response with increased neutrophil numbers and reduced neutrophil apoptosis PMID: 21562052
    34. Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB activation. PMID: 21627969
    35. study concludes that TRAIL attenuates plaque size at early stages of atherosclerosis PMID: 21324463
    36. TRAIL and osteoprotegerin are expressed in atherosclerotic plaques in a calcification-prone mouse model PMID: 21426505
    37. Data show that the number of tumors observed in TRAIL transgenic animals was significantly lower than in the control animals, and the lesions observed were mostly benign. PMID: 21463519
    38. is not required for the development of peripheral lymphopenia or granuloma necrosis during infection with Mycobacterium avium PMID: 21470210
    39. resveratrol can enhance the apoptosis-inducing potential of TRAIL by activating FKHRL1 and its target genes PMID: 21209944
    40. CD8-positive regulatory T cells generated after anterior chamber injection of antigen via the retro-orbital plexus enforce systemic tolerance in a TRAIL-dependent manner to inhibit inflammation in the eye. PMID: 21169546
    41. TRAIL suppresses autoimmunity by two mechanisms: the inhibition of Th1 cells and the promotion of Tregs PMID: 20921531
    42. extrinsic and intrinsic pathways, via Trail/Dr5 and Puma respectively, could be engaged in distinct subpopulations of spermatogonia PMID: 20711434
    43. sTRAIL is inversely associated with the mortality risk in chronic kidney disease patients. PMID: 20190248
    44. Data show that in Abelson cells, the inhibition of both NF-kappaB and FoxO3a activity is required for suppression of TRAIL transcription and maintenance of the transformed state. PMID: 20213318
    45. TRAIL- and GITRL-activated pathways synergise in the development of SCI-related inflammatory damage. PMID: 20107429
    46. apoptotic cells generated during sepsis induced a CD8+ regulatory T cell that suppressed delayed-type hypersensitivity by TRAIL production PMID: 20483771
    47. results indicate that cells that survive TRAIL treatment may do so by activation of a TAK1-NF-kappaB pathway that drives expression of cFlipL, and suggest that TAK1 may be a good target for overcoming TRAIL resistance PMID: 20062539
    48. mice defective in both tumor necrosis factor-related apoptosis-inducing ligand and Fas ligand reveal new roles for TRAIL in lymphocyte homeostasis and autoimmune lymphoproliferative syndromes PMID: 20185587
    49. TRAIL induction involves FGF-2, Sp1-phosphorylation and NFkappaB and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury. PMID: 20150555
    50. Data show that alpha-GalCer/AdmIL-2 treatment expanded the absolute numbers of lung and liver NK, NKT and T-cells as well as the TNF-related apoptosis-inducing ligand (TRAIL) expression of these cells. PMID: 19901518

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族:
    Tumor necrosis factor family
  • 組織特異性:
    Widespread.
  • 數據庫鏈接:

    KEGG: mmu:22035

    STRING: 10090.ENSMUSP00000040271

    UniGene: Mm.1062



主站蜘蛛池模板: 中文字幕人妻无码系列第三区| 国产成人av性色在线影院色戒| 天天躁夜夜躁狠狠躁2021a2| 亚洲精品网站在线观看你懂的| 国产熟人av一二三区| 国产97色在线 | 免| 久久精品熟女亚州av麻豆| 在线偷着国产精选视频| 777米奇色狠狠俺去啦奇米77| 国产啪精品视频网站| 欧洲熟妇牲交| 久久久久国产精品人妻aⅴ牛牛| a∨在线视频播放| 久久99精品国产99久久6不卡| 午夜福利电影| 精品国产不卡一区二区三区| 色婷婷综合和线在线| 国产乱子伦一区二区三区四区五区 | 国产在线拍揄自揄视频网试看| 免费无码专区在线视频| 99国产精品久久久久久久日本竹| 夜爽8888视频在线观看| 天天做天天爱夜夜爽毛片| 男女高潮喷水在线观看| 成人性做爰aaa片免费看不忠| 亚洲天堂2017无码中文| 无码少妇高潮浪潮av久久| 日本丰满熟妇hd| 女人与拘性猛交视频| 两性色午夜视频免费播放 | 52熟女露脸国语对白视频| 国产av国片精品有毛| 高潮喷水的毛片| 国产成人人人97超碰超爽8| 99视频有精品视频高清| 久久97超碰色中文字幕总站| 人妻无码一区二区三区四区| 日韩精品中文字幕无码专区| 人妻 偷拍 无码 中文字幕| 国产精品毛片大码女人| 欧美疯狂性受xxxxx喷水|