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Mouse serum amyloid A1 (SAA1) ELISA kit

  • 中文名稱:
    小鼠血清淀粉樣蛋白A1(SAA1)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL020656MO
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠血清淀粉樣蛋白A1(SAA1)酶聯(lián)免疫試劑盒(CSB-EL020656MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿,組織勻漿樣本中的SAA1含量。SAA1即血清淀粉樣蛋白A1,是一種急性期蛋白。在炎癥、感染等情況下其表達(dá)顯著上調(diào)。研究機(jī)制方面,它參與免疫反應(yīng)調(diào)節(jié),能趨化免疫細(xì)胞。異常表達(dá)可能與動(dòng)脈粥樣硬化、類風(fēng)濕關(guān)節(jié)炎等疾病發(fā)生發(fā)展相關(guān),可作為潛在疾病標(biāo)志物與治療靶點(diǎn)。試劑盒檢測范圍為3.12 ng/ml- 200 ng/ml,靈敏度為0.78 ng/ml。適用于實(shí)驗(yàn)動(dòng)物模型中炎癥反應(yīng)評估、感染性疾病進(jìn)程監(jiān)測以及代謝綜合征、動(dòng)脈粥樣硬化等慢性炎癥相關(guān)研究;適用于實(shí)驗(yàn)室開展批量樣本檢測及長期動(dòng)態(tài)觀察研究,為探索SAA1在炎癥調(diào)控、免疫應(yīng)答及疾病病理機(jī)制中的功能提供可靠工具本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Saa1 ELISA Kit; Serum amyloid A-1 protein ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma,tissue homogenates
  • 檢測范圍:
    3.12 ng/ml - 200 ng/ml
  • 靈敏度:
    0.78 ng/ml
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度:

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse SAA1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

    Sample

    Serum(n=4)

    1:200

    Average %

    90

    Range %

    85-96

    1:400

    Average %

    92

    Range %

    89-95

    1:800

    Average %

    91

    Range %

    87-96

    1:1600

    Average %

    95

    Range %

    86-101

  • 回收率:

    The recovery of mouse SAA1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    88

    82-94

    EDTA plasma (n=4)

    96

    90-101

  • 標(biāo)準(zhǔn)曲線:

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    200

    2.200

    2.100

    2.150

    2.055

    100

    1.405

    1.305

    1.355

    1.260

    50

    0.802

    0.782

    0.792

    0.697

    25

    0.435

    0.425

    0.430

    0.335

    12.5

    0.304

    0.294

    0.299

    0.204

    6.25

    0.201

    0.191

    0.196

    0.101

    3.12

    0.147

    0.146

    0.147

    0.052

    0

    0.095

    0.094

    0.095

     

  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展:
    SAA1是血漿淀粉樣蛋白A1的縮寫,是一種急性相應(yīng)蛋白,最近的研究表明其與疾病的發(fā)生和發(fā)展密切相關(guān)。
  • 功能:
    Major acute phase protein.
  • 基因功能參考文獻(xiàn):
    1. Study concludes that the transfer of serum amyloid A1 protein depends on direct cell-to-cell contacts or tunneling nanotubes. PMID: 28361953
    2. High SAA1 expression in the stromal component is associated with pancreatic tumors. PMID: 29351990
    3. findings show that high-density lipoprotein binding blocks fibril formation from soluble SAA1 protein, whereas internalization into mononuclear phagocytes leads to formation of amyloid; SAA1 aggregation in the cell model disturbs the integrity of vesicular membranes and leads to lysosomal leakage and apoptotic death PMID: 28637682
    4. These findings suggest that A-SAA is functionally linked to pulmonary inflammation in this O3 exposure model and that A-SAA could be an important systemic signal of O3 exposure to the CNS.- PMID: 28533327
    5. SAA and TLR4 have a role in skin inflammation PMID: 27502577
    6. Data indicate that SAA1 overexpressing mice (TG) show significant deficits in social behaviors, including impaired social recognition and reduced social interaction. Study detected exogenous SAA1 expression in the brain of TG mice, implying that liver-derived SAA1 migrates to the brain. Results show an increase in the accumulation of the 87kDa form of Abeta in TG mice compared to wild type mice. PMID: 27608955
    7. Sustained, elevated levels of SAA1 were correlated with metabolic parameters and local cytokine expression in the liver following 16 weeks on the high-fat diet. We suggest that SAA1-derived amyloid deposition under long-term high-fat diet exposure may be associated with the complications of high-fat diet-induced obesity and metabolic disorders. PMID: 27218680
    8. Serum Amyloid A induces inflammation, proliferation and cell death in activated hepatic stellate cells. PMID: 26937641
    9. Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL PMID: 26022803
    10. Serum amyloid A1alpha induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. PMID: 26297794
    11. Robust IL-17A production was restricted to the ileum, where SFB makes direct contact with the epithelium and induces serum amyloid A proteins 1 and 2 (SAA1/2), which promote local IL-17A expression in RORgammat(+) T17 cells. PMID: 26411290
    12. SAA protein levels increased in both serum and lung within 2-24h after mice were exposed to Aspergillus spores. SAA mRNA levels increased within the first hour after mice were exposed to A. fumigatus. PMID: 23603100
    13. Saa1 might be a novel inflammatory factor that acts as a chemokine modulator in hepatitis. PMID: 25847238
    14. GAGs may have an intrinsic and divergent influence on the aggregation and fibrillation of HDL-free SAA1.1 in vivo PMID: 24878279
    15. CE/J mice possess functional Saa1 and Saa2 genes with identical amino acid sequence. PMID: 24228751
    16. we find no evidence that adipose tissue-derived hSAA1 influences the development of insulin resistance or obesity-related inflammation. PMID: 23967285
    17. Its gene hold broader diversity and greater complexity and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus lineage. PMID: 24521869
    18. The absence of endogenous SAA1.1 and 2.1 does not affect atherosclerotic lipid deposition in apolipoprotein E-deficient mice fed either normal or Western diets. PMID: 24265416
    19. SAA up-regulates Lp-PLA2 production significantly via a FPRL1/MAPKs./PPAR-gamma signaling pathway. PMID: 23623642
    20. Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2 PMID: 23223242
    21. An increase in plasma SAA directly accelerates the progression of atherosclerosis in ApoE-/- mice. PMID: 21953420
    22. SAA does not impact High Density Lipoprotein levels, apoA-I clearance, or High Density Lipoprotein size PMID: 20667817
    23. Infusions of SAA-positive cells promote renal recovery after acute renal failure and offer a potentially powerful and novel therapy of renal failure. PMID: 20534870
    24. Serum amyloid A has a role in promoting cholesterol efflux mediated by scavenger receptor B-I PMID: 16120612
    25. Plasma A-SAA elevation was due to induction of Saa1 and Saa2 expression in liver but not in adipose tissue. PMID: 18584041

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  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    SAA family
  • 組織特異性:
    Detected in blood plasma (at protein level). Detected in liver.
  • 數(shù)據(jù)庫鏈接:


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