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  4. Mouse neurotensin (NTS) ELISA kit

Mouse neurotensin (NTS) ELISA kit

  • 中文名稱：
    小鼠神經(jīng)降壓素(NTS)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL016136MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠神經(jīng)降壓素(NTS)酶聯(lián)免疫試劑盒（CSB-EL016136MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的NTS含量。試劑盒檢測(cè)范圍為6.25 pg/mL-400 pg/mL，該產(chǎn)品為神經(jīng)生物學(xué)、代謝調(diào)控及消化系統(tǒng)疾病研究提供可靠工具，可應(yīng)用于探究NTS在神經(jīng)信號(hào)傳導(dǎo)、能量代謝紊亂或藥物干預(yù)實(shí)驗(yàn)中的作用機(jī)制，特別適用于肥胖模型、精神分裂癥動(dòng)物模型及相關(guān)分子通路研究中的靶標(biāo)分子定量分析本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Nts ELISA Kit; Neurotensin/neuromedin N [Cleaved into: Large neuromedin N ELISA Kit; NmN-125); Neuromedin N ELISA Kit; NN ELISA Kit; NmN); Neurotensin ELISA Kit; NT); Tail peptide] ELISA Kit
  • 縮寫：
    NTS
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse NTS in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 86    
    Range % 83-89    
    1:2 Average % 98    
    Range % 94-105    
    1:4 Average % 90    
    Range % 85-95    
    1:8 Average % 107    
    Range % 103-110    
  • 回收率：
    The recovery of mouse NTS spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 86 83-89    
    EDTA plasma (n=4) 97 94-101    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    400 2.890 2.768 2.829 2.637    
    200 2.346 2.204 2.275 2.083    
    100 1.626 1.702 1.664 1.472    
    50 1.047 1.100 1.074 0.882    
    25 0.733 0.741 0.737 0.545    
    12.5 0.517 0.502 0.510 0.318    
    6.25 0.371 0.382 0.377 0.185    
    0 0.191 0.193 0.192 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
  • 基因功能參考文獻(xiàn)：
    1. Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior. PMID: 29478718
    2. The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior. PMID: 29241540
    3. Nts-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors. PMID: 28323938
    4. findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment PMID: 27193687
    5. Data (including data from studies in transgenic mice) suggest Nts, glucagon-like peptide I, and peptide YY are closely co-expressed/co-secreted within enteroendocrine cells in ileum mucosa; however, Nts is stored in distinct/separate secretory granules. PMID: 26469136
    6. The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported. PMID: 25031361
    7. These observations suggest the importance of neurotensin in maintaining activity of orexin neurons. PMID: 23620827
    8. a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin PMID: 23064014
    9. Neurotensin knock-out mice do not differ from their wild-type or heterozygous littermates in either baseline or acute cocaine-stimulated locomotor activity. PMID: 21720755
    10. Neurotensin increases EGF expression in skin dendritic cells. PMID: 21767580
    11. NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC-mediated phosphorylation of the D2R, leading to heterologous receptor desensitization. PMID: 21233215
    12. although neurotensin neurons in the anteroventral periventricular nucleus are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse PMID: 19861584
    13. neurotensin has a role in chronic mitogen-activated protein kinase activation and cancer progression PMID: 14699144
    14. Data show that although brain neuromedin N mRNA distribution largely overlaps in mice and rats, species differences exist in specific brain areas, and the distribution in mice resembles that of primates more than that of rats. PMID: 15193419
    15. NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway. PMID: 15764810
    16. Neurotensin may have a direct role in the neuroendocrine control of feeding and energy homeostasis. PMID: 16221860
    17. co-localization of peptides and enzyme in GHRH-eGFP neurons displays a sexual dimorphism at 3-month of age for NT, and at 8-month for tyrosine hydroxylase, while the total number of GHRH-eGFP neurons does not exhibit gender difference at either age. PMID: 17137749
    18. [(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours. PMID: 17594090
    19. These results clearly indicate for the first time that NT is able to protect endocrine beta cells from external cytotoxic agents, a role well correlated with its release in the circulation after a meal. PMID: 18456542
    20. NT-mediated IL-6 expression is nuclear factor-kappaB and PKCdelta dependent PMID: 19443690

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  • 亞細(xì)胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle.
  • 蛋白家族：
    Neurotensin family
  • 數(shù)據(jù)庫(kù)鏈接：


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