在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse neuromedin U (NMU) ELISA kit

Mouse neuromedin U (NMU) ELISA kit

  • 中文名稱：
    小鼠神經調節肽U(NMU)酶聯免疫試劑盒
  • 貨號：
    CSB-EL015902MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠神經調節肽U(NMU)酶聯免疫試劑盒（CSB-EL015902MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的NMU含量。NMU即神經調節素U，是一種神經肽。它在能量代謝、心血管功能、生殖等方面發揮重要生理作用。研究機制主要是通過與受體結合，激活下游信號通路來調節多種生理過程，目前其在疾病治療如肥胖癥等方面的研究頗具潛力。試劑盒檢測范圍為0.9 ng/mL-60 ng/mL，特別適用于探究NMU在肥胖機制、神經信號傳導或能量代謝相關疾病模型中的作用機制研究；為神經科學、代謝調控及生理病理學領域的科研工作者提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    NmuNeuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 ELISA Kit; NURP36); Neuromedin precursor-related peptide 33 ELISA Kit; NURP33); Neuromedin-U-23 ELISA Kit; NmU-23)] ELISA Kit
  • 縮寫：
    NMU
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.9 ng/mL-60 ng/mL
  • 靈敏度：
    0.225 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse NMU in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %98
    Range %94-105
    1:2Average %91
    Range %85-97
    1:4Average %90
    Range %85-94
    1:8Average %100
    Range %95-106
  • 回收率：
    The recovery of mouse NMU spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8985-93
    EDTA plasma (n=4)9590-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1OD2AverageCorrected
    602.609 2.563 2.586 2.462
    301.842 1.805 1.824 1.700
    151.251 1.302 1.277 1.153
    7.50.765 0.804 0.785 0.661
    3.750.513 0.537 0.525 0.401
    1.80.304 0.321 0.313 0.189
    0.90.237 0.231 0.234 0.110
    00.126 0.121 0.124
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.; Stimulates muscle contractions of specific regions of the gastrointestinal tract.
  • 基因功能參考文獻：
    1. These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH. PMID: 29017855
    2. Loss of NMU-NMUR1 signalling reduced ILC2 frequency and effector function, and altered transcriptional programs following allergen challenge in vivo. Thus, NMUR1 signalling promotes inflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflammation at mucosal surfaces. PMID: 28902842
    3. data indicate that the NMU-NMUR1 neuronal signaling circuit provides a selective mechanism through which the enteric nervous system and innate immune system integrate to promote rapid type 2 cytokine responses that can induce anti-microbial, inflammatory and tissue-protective type 2 responses at mucosal sites PMID: 28869965
    4. NMU treatment in vivo resulted in immediate protective type 2 responses; accordingly, group 2 innate lymphoid cells -autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection PMID: 28869974
    5. These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. PMID: 28864416
    6. These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU. PMID: 26826380
    7. the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing. PMID: 25895852
    8. Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U. PMID: 23892031
    9. Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice. PMID: 22314006
    10. investigation of neuromedin U effects on factors associated with obesity/diabetes: NMU reduced food consumption/body weight; NMU increased body temperature/metabolic rate; NMU improved glucose tolerance; these effects seem to be mediated by NMUR1 PMID: 21586559
    11. Analysis of NMU expression in ob/ob mice revealed elevated NMU mRNA levels in the dorsomedial hypothalamic (DMH) nucleus of ob/ob mice compared to lean litter-mates. NMU mRNA levels were elevated in the DMH of mice fasted for 24 h relative to controls PMID: 14622096
    12. results suggest that endogenous NMU may be involved in reflexes and adaptation to environmental stimuli PMID: 15369794
    13. NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway. PMID: 15448684
    14. NMU receptor antagonists could be novel targets for pharmacological inhibition of allergic inflammatory diseases, including asthma. PMID: 16373672
    15. data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages PMID: 16466693
    16. A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor] PMID: 16474416
    17. results indicate that NMU suppresses gonadotropin secretion and regulates the onset of puberty PMID: 16716306
    18. Central control of bone remodeling by Nmu is reported. PMID: 17873881
    19. negative regulator of bone formation through the molecular clock PMID: 18761104
    20. proNMU(104-136) is a novel modulator of energy balance and may contribute to the phenotype exhibited by NMU knockout mice. PMID: 19531638

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    NmU family
  • 數據庫鏈接：


主站蜘蛛池模板： 性色香蕉av久久久天天网| 久久婷婷五月综合色d啪| 大肉大捧一进一出好爽动态图| 亚洲精品久久片久久久久| 国产成人亚洲精品无码青青草原 | 亚洲欧洲免费三级网站| 亚洲视频日韩视欧美视频| yy111111少妇无码影院| 亚洲午夜无码av毛片久久| 欧美国产日产一区二区| 国产成人免费无庶挡视频| 国产亚洲精品久久久闺蜜 | 亚洲大尺度专区无码浪潮av| 欧美丰满老妇性猛交| 国产亚洲精品一区二区三区| 黄瓜视频在线观看| 男人边吻奶边挵进去视频| 国语精品自产拍在线观看网站| 成年女人毛片免费视频| 黑人好猛厉害爽受不了好大撑| 女m羞辱调教视频网站| 亚洲一区二区三区自拍天堂| 欧美成人一区二区三区片免费 | 特黄三级又爽又粗又大| 日韩人妻一区二区三区免费| 国产二级一片内射视频播放| 国产免费人成视频在线播放播| 亚洲国产成人一区二区三区| 午夜性刺激免费看视频| 国产喷水1区2区3区咪咪爱av| 国产午夜福利在线播放87| 日韩欧美亚洲综合久久影院| 白又丰满大屁股bbbbb| 国产乱子伦精品免费女| 亚欧成人中文字幕一区| 亚洲综合色区中文字幕| 精品无码一区二区三区爱欲九九| 在线看片无码永久免费视频| h无码精品3d动漫在线观看 | 99尹人香蕉国产免费天天| 欧美极品色午夜在线视频|