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  4. Mouse neuromedin U (NMU) ELISA kit

Mouse neuromedin U (NMU) ELISA kit

  • 中文名稱：
    小鼠神經調節肽U(NMU)酶聯免疫試劑盒
  • 貨號：
    CSB-EL015902MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠神經調節肽U(NMU)酶聯免疫試劑盒（CSB-EL015902MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的NMU含量。NMU即神經調節素U，是一種神經肽。它在能量代謝、心血管功能、生殖等方面發揮重要生理作用。研究機制主要是通過與受體結合，激活下游信號通路來調節多種生理過程，目前其在疾病治療如肥胖癥等方面的研究頗具潛力。試劑盒檢測范圍為0.9 ng/mL-60 ng/mL，特別適用于探究NMU在肥胖機制、神經信號傳導或能量代謝相關疾病模型中的作用機制研究；為神經科學、代謝調控及生理病理學領域的科研工作者提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    NmuNeuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 ELISA Kit; NURP36); Neuromedin precursor-related peptide 33 ELISA Kit; NURP33); Neuromedin-U-23 ELISA Kit; NmU-23)] ELISA Kit
  • 縮寫：
    NMU
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.9 ng/mL-60 ng/mL
  • 靈敏度：
    0.225 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse NMU in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %98
    Range %94-105
    1:2Average %91
    Range %85-97
    1:4Average %90
    Range %85-94
    1:8Average %100
    Range %95-106
  • 回收率：
    The recovery of mouse NMU spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8985-93
    EDTA plasma (n=4)9590-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1OD2AverageCorrected
    602.609 2.563 2.586 2.462
    301.842 1.805 1.824 1.700
    151.251 1.302 1.277 1.153
    7.50.765 0.804 0.785 0.661
    3.750.513 0.537 0.525 0.401
    1.80.304 0.321 0.313 0.189
    0.90.237 0.231 0.234 0.110
    00.126 0.121 0.124
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.; Stimulates muscle contractions of specific regions of the gastrointestinal tract.
  • 基因功能參考文獻：
    1. These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH. PMID: 29017855
    2. Loss of NMU-NMUR1 signalling reduced ILC2 frequency and effector function, and altered transcriptional programs following allergen challenge in vivo. Thus, NMUR1 signalling promotes inflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflammation at mucosal surfaces. PMID: 28902842
    3. data indicate that the NMU-NMUR1 neuronal signaling circuit provides a selective mechanism through which the enteric nervous system and innate immune system integrate to promote rapid type 2 cytokine responses that can induce anti-microbial, inflammatory and tissue-protective type 2 responses at mucosal sites PMID: 28869965
    4. NMU treatment in vivo resulted in immediate protective type 2 responses; accordingly, group 2 innate lymphoid cells -autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection PMID: 28869974
    5. These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. PMID: 28864416
    6. These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU. PMID: 26826380
    7. the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing. PMID: 25895852
    8. Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U. PMID: 23892031
    9. Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice. PMID: 22314006
    10. investigation of neuromedin U effects on factors associated with obesity/diabetes: NMU reduced food consumption/body weight; NMU increased body temperature/metabolic rate; NMU improved glucose tolerance; these effects seem to be mediated by NMUR1 PMID: 21586559
    11. Analysis of NMU expression in ob/ob mice revealed elevated NMU mRNA levels in the dorsomedial hypothalamic (DMH) nucleus of ob/ob mice compared to lean litter-mates. NMU mRNA levels were elevated in the DMH of mice fasted for 24 h relative to controls PMID: 14622096
    12. results suggest that endogenous NMU may be involved in reflexes and adaptation to environmental stimuli PMID: 15369794
    13. NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway. PMID: 15448684
    14. NMU receptor antagonists could be novel targets for pharmacological inhibition of allergic inflammatory diseases, including asthma. PMID: 16373672
    15. data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages PMID: 16466693
    16. A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor] PMID: 16474416
    17. results indicate that NMU suppresses gonadotropin secretion and regulates the onset of puberty PMID: 16716306
    18. Central control of bone remodeling by Nmu is reported. PMID: 17873881
    19. negative regulator of bone formation through the molecular clock PMID: 18761104
    20. proNMU(104-136) is a novel modulator of energy balance and may contribute to the phenotype exhibited by NMU knockout mice. PMID: 19531638

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    NmU family
  • 數據庫鏈接：


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