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Mouse matrix metalloproteinase 8/Neutrophil collagenase,MMP-8 ELISA kit

  • 中文名稱:
    小鼠基質金屬蛋白酶8/中性粒細胞膠原酶(MMP-8)酶聯免疫試劑盒
  • 貨號:
    CSB-E07407m
  • 規格:
    96T/48T
  • 價格:
    ¥3200/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠基質金屬蛋白酶8/中性粒細胞膠原酶(MMP-8)酶聯免疫試劑盒(CSB-E07407m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的MMP8含量。MMP8 即基質金屬蛋白酶 8,是體內參與降解細胞外基質的酶。其背景上,它與組織重塑、炎癥等生理病理過程相關。研究機制方面,主要是通過降解特定底物,如膠原蛋白等,在創傷修復、腫瘤侵襲轉移等方面發揮重要作用。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,本試劑盒廣泛用于基礎醫學研究中MMP-8相關信號通路解析、藥物干預效果評估以及疾病模型構建等場景,為炎癥機制探索、組織工程研究及免疫調節實驗提供高效分析工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Mmp8 ELISA Kit; Neutrophil collagenase ELISA Kit; EC 3.4.24.34 ELISA Kit; Collagenase 2 ELISA Kit; Matrix metalloproteinase-8 ELISA Kit; MMP-8 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cancer
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

  • 線性度:

  • 回收率:

  • 標準曲線:

  • 數據處理:
  • 貨期:
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 功能:
    Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution.
  • 基因功能參考文獻:
    1. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8. PMID: 28283184
    2. MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3 PMID: 27435263
    3. These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression. PMID: 26923552
    4. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia. PMID: 25421209
    5. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window. PMID: 26111477
    6. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web. PMID: 25848906
    7. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin and therefore increasing the bioavailability of TGF-beta. PMID: 26092731
    8. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I levels. PMID: 25550459
    9. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha activity, which may explain neuroinflammation in septic mouse brain. PMID: 25049354
    10. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10, N-cadherin, and beta-catenin-mediated pathway and plays an important role in neointima formation. PMID: 24158518
    11. Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo. PMID: 23512982
    12. MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions. PMID: 23071158
    13. These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia. PMID: 22768176
    14. Mmp-8 has a protective role in arthritis PMID: 21190566
    15. MMP-8 is not essential for neutrophil migration in arthritis and likely other autoimmune diseases. Rather, MMP-8 is important for normal rates of neutrophil apoptosis and hence regulates cell clearance. PMID: 21120997
    16. MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit ventilator-induced lung injury. PMID: 19995943
    17. MMP-8 potently reduces the accumulation of neutrophils and macrophages in the lungs of mice with lipopolysaccharide- and bleomycin-induced acute lung injury. PMID: 20042585
    18. These results indicate that bradykinin at reperfusion triggers its cardioprotective signalling pathway through MMP-8-dependent transactivation of the EGFR. PMID: 19583703
    19. In vitro, fewer MMP-8(-/-) PMNs migrated thru 3D cross-linked collagen gels than WT PMNs.This was likely a result of pericollagenase activity of MMP-8, as WT PMNs expressing MMP-8 could not migrate effectively thru collagen resistant to the collagenase. PMID: 19801498
    20. immunohistochemistry of embryos between E9.5-E14.5 demonstrated MMP-8 expression in the surface ectoderm, neural crest cells and chondrocytes PMID: 11731274
    21. highly elevated expression of MMP-8 (neutrophil collagenase) mRNA and protein in experimental autoimmune encephalomyelitis; colocalizing to neutrophil infiltrates found in brain and extensively in the spinal cord submeningeal space PMID: 11985514
    22. protective role for Mmp8 in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility PMID: 14517555
    23. membrane-bound MMP-8 accounts for 92% of the MMP-mediated, PMN surface type I collagenase activity PMID: 15187163
    24. MMP-8 demonstrates an anti-inflammatory effect in allergic asthma and is implicated in the cascade of events leading to neutrophil apoptosis. PMID: 16081833
    25. As seen in knockout mice, MMP-8 participates in wound repair by contributing to the resolution of inflammation and opens the possibility to develop new strategies for treating wound healing defects. PMID: 17392479
    26. MMP-8 plays an important role in EAE development and propose that this enzyme may be a novel therapeutic target in human neuro-inflammatory diseases such as multiple sclerosis. PMID: 18245084
    27. Loss of matrix metalloproteinase-8 is associated with tongue carcinogenesis PMID: 18253113
    28. C-Jun-NH(2)-terminal kinase also involved in alveolo-capillary leakage and edema formation, whereas MMP8 inhibited alveolo-capillary protein leakage. PMID: 18270588
    29. MMP-8 is a tumor protective factor, which also has the ability to reduce the metastatic potential of malignant cells in both mice and human. PMID: 18413742
    30. MMP-8 regulates neutrophil migration through the extracellular matrix of the corneal stroma by generating chemotactic Pro-Gly-Pro during inflammation PMID: 18556780
    31. study concludes that matrix metalloproteinase-8 cleaves IL-13 receptor alpha2 (IL-13R alpha 2) in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
    32. MMP-8 appears to act in a protective manner inhibiting the development of bacterium-induced periodontal tissue destruction, possibly through the processing anti-inflammatory cytokines and chemokines. PMID: 19029300
    33. Data suggest that antigen challenge via the airway activates Gr-1(+) cells and consequently MMP to facilitate the recruitment of Th cells in the airway inflammatory response. PMID: 19593770
    34. Results indicate that MMP8 is an important player in atherosclerosis. PMID: 19745165

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  • 亞細胞定位:
    Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules and released during inflammatory conditions.
  • 蛋白家族:
    Peptidase M10A family
  • 組織特異性:
    Neutrophils. Expressed in uterus. Low levels in kidney and muscle.
  • 數據庫鏈接:


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