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  4. Mouse bone morphogenetic protein 9,BMP-9 ELISA Kit

Mouse bone morphogenetic protein 9,BMP-9 ELISA Kit

  • 中文名稱：
    小鼠骨成型蛋白9(BMP-9)酶聯免疫試劑盒
  • 貨號：
    CSB-E14282m
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠骨成型蛋白9(BMP-9)酶聯免疫試劑盒（CSB-E14282m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的GDF2含量。GDF2（生長分化因子2）是一種分泌性的TGF-β超家族蛋白質的配體，其結合TGF-β受體，激活SMAD家族轉錄因子，調控基因表達。GDF2在軟骨和骨發育、血管生成及膽堿能中樞神經系統神經元分化中起重要作用。研究顯示，GDF2變異與肺動脈高壓（PAH）和遺傳性出血性毛細血管擴張癥（HHT）相關。試劑盒檢測范圍為0.312 pg/mL-20 pg/mL，本試劑盒通過高特異性抗體對實現目標蛋白的捕獲與檢測，操作流程標準化，可在4.5小時內完成檢測，為研究BMP - 9在神經生物學、骨骼疾病模型或代謝調控機制中的功能提供可靠工具，廣泛適用于細胞實驗、動物模型或相關分子通路的基礎科研。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Gdf2 ELISA Kit; Bmp9Growth/differentiation factor 2 ELISA Kit; GDF-2 ELISA Kit; Bone morphogenetic protein 9 ELISA Kit; BMP-9 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    0.312 pg/mL-20 pg/mL
  • 靈敏度：
    0.078 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse BMP-9 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %100
    Range %91-104
    1:2Average %104
    Range %97-108
    1:4Average %98
    Range %89-102
    1:8Average %94
    Range %89-99
  • 回收率：
    The recovery of mouse BMP-9 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9989-103
    EDTA plasma (n=4)9485-98
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    202.266 2.231 2.249 2.081
    101.389 1.296 1.343 1.175
    50.850 0.834 0.842 0.674
    2.50.582 0.531 0.557 0.389
    1.250.422 0.441 0.432 0.264
    0.6250.316 0.303 0.310 0.142
    0.3120.249 0.233 0.241 0.073
    00.170 0.166 0.168
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
  • 基因功能參考文獻：
    1. Low BMP9 expression is associated with breast cancer. PMID: 30015950
    2. These results suggest that RUNX1 may be an essential modulator in BMP9- induced osteogenic differentiation of mesenchymal stem cells. PMID: 28644396
    3. results provide a better understanding into how BMP-9 induces osteoblast differentiation and its synergy with IGF-2 at the signaling level. PMID: 27477105
    4. Our findings provide a clearer understanding of the cellular pathways utilized by BMP-9 for chondrogenesis that may help improve current therapies for regenerative cartilage repair. PMID: 27056281
    5. Constitutive expression of low levels of BMP-9 stabilises hepatocyte function in the healthy liver. High levels of BMP-9 cause enhanced damage upon acute or chronic injury. PMID: 28336518
    6. Notch signaling may play an important role in BMP9-induced osteogenesis and angiogenesis. It's conceivable that simultaneous activation of the BMP9 and Notch pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering. PMID: 28384643
    7. he results of the present study demonstrated that BMP9 promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 signaling pathways in the cell PMID: 27748860
    8. that Dkk1 negatively regulates BMP9-induced osteogenic differentiation. PMID: 26674341
    9. Data show athat beta-catenin can be activated by bone morphogenetic protein 9 (BMP9) and the activation of beta-catenin plays an important role in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by BMP9. PMID: 27371840
    10. miR23b inhibits BMP9induced C2C12 myoblast osteogenesis via targeting of the Runx2 gene, acting as a suppressor. PMID: 26820568
    11. We have established a producer line that stably expresses a high level of active BMP9 protein. Such producer line should be a valuable resource for generating biologically active BMP9 protein for studying BMP9 signaling PMID: 26816490
    12. Data show that microRNA miR-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 protein. PMID: 26460584
    13. Hh signaling is involved and plays a regulatory role in the osteogenic differentiation of MSCs induced by BMP9. PMID: 25872645
    14. data indicate that BMP9 and BMP13 (BMP9 might be more effective) promoted the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells PMID: 24380493
    15. BMP9/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9/ALK1 may improve the efficacy of EPC-based therapies for treating ischemic diseases. PMID: 26229139
    16. BMP-9 induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1, Smad and ALP dependent mechanisms. PMID: 25297851
    17. These findings suggest that PTEN plays an important role in regulating BMP9 induced osteogenic differentiation in MPCs, which may be mediated by PTEN/PI3K/Akt signaling to modulate the expression of COX-2. PMID: 25176064
    18. BMP9 may be explored as a novel and efficacious factor for odontogenic regeneration. PMID: 24517722
    19. IGF2 increased the protein levels of hippocampal BMP9, NGF, BDNF, NT3 and IGF1 and of doublecortin, a marker of neurogenesis. PMID: 24732467
    20. Data indicate that extracellular signal-regulated kinase 5 (ERK5) and c-Jun N-terminal kinase (JNK) are important in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by bone morphogenetic protein 9 (BMP9) transfection. PMID: 25108436
    21. results strongly suggest that Creld2 may be directly regulated by BMP9 and ER stress response may play an important role in regulating osteogenic differentiation PMID: 24019898
    22. FGF2 inhibited BMP9-induced osteogenic differentiation by blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in mesenchymal stem cells. PMID: 23680673
    23. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. PMID: 24218590
    24. Bmp9 mediates the inhibitory effects on lymphatic vessel formation of ALK-1 signaling. PMID: 24133138
    25. BMP-9 maintains epithelial polarity via intracellular signaling from basolaterally localized BMP receptors. PMID: 23675417
    26. BMP9 is an important extracellular regulator in the maturation of the lymphatic vascular network affecting valve development and lymphatic vessel function. PMID: 23741013
    27. BMP-9 induced osteogenic differentiation of dental follicle stem cells depended on MAPK signaling pathway. PMID: 23155360
    28. in an in vitro model of HHT2, loss of Alk1 blocks BMP9 signaling, resulting in reduced EphrinB2 expression, enhanced VEGFR2 expression, and misregulated EC sprouting and anastomosis PMID: 22622516
    29. Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells PMID: 22467218
    30. platelets regulate blood/lymphatic vessel separation by inhibiting the proliferation, migration, and tube formation of LECs, mainly because of the release of BMP-9 upon activation by CLEC-2/podoplanin in PMID: 22556408
    31. During mouse development circulating levels of BMP9 peaked during the first 3 weeks after birth and then decreased to 2 ng/mL in adulthood. PMID: 21710321
    32. Results demonstrated that BMPRII and ActRII are the functional type II TGF-beta receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 cells. PMID: 20801928
    33. BMP-9 crosstalks with IGF-2 through PI3K/AKT signaling pathway during osteogenic differentiation of mesenchymal stem cells. PMID: 20499340
    34. Chromatin immunoprecipitation (ChIP) analysis indicated that BMP-9 induced recruitment of both Runx2 and beta-catenin to the osteocalcin promoter PMID: 19175684
    35. Therefore, pBMP-9 might be a promising replacement for costly BMP in tissue engineering applications that require a well-defined serum-free medium. PMID: 19388833
    36. ALK-1, an orphan receptor in the TGF-beta family, is a potential receptor for BMP-9 PMID: 15851468
    37. BMP9 induces the transcriptome of basal forebrain cholinergic neurons PMID: 15870197
    38. Hey1 and Runx2 were shown to act synergistically in BMP9-induced osteogenic differentiation, and Runx2 expression significantly decreased in the absence of Hey1, suggesting that Runx2 may function downstream of Hey1 PMID: 18986983

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數據庫鏈接：


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