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  4. Mouse beta cellulin,BTC ELISA Kit

Mouse beta cellulin,BTC ELISA Kit

  • 中文名稱：
    小鼠β細胞素(BTC)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E07307m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠β細胞素(BTC)酶聯(lián)免疫試劑盒（CSB-E07307m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的BTC含量。試劑盒檢測范圍為62.5 pg/ml-4000 pg/ml，適用于胰腺相關(guān)疾病模型研究、組織再生機制探索以及代謝調(diào)控實驗，能夠有效支持體外培養(yǎng)細胞、動物模型組織或體液樣本中BTC動態(tài)表達的定量分析，為揭示β細胞功能調(diào)控網(wǎng)絡(luò)提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Btc ELISA kit; BcnProbetacellulin [Cleaved into: Betacellulin ELISA kit; BTC)] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    62.5 pg/ml -4000 pg/ml
  • 靈敏度：
    15.6 pg/ml
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
  • 基因功能參考文獻：
    1. Betacellulin promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1/Erk2. PMID: 29331377
    2. The results of this study suggested a novel regulatory role of Btc in axon-Schwann cell interactions involved in myelin formation and nerve repair. PMID: 28139851
    3. BTC induces expansion of neural stem cells and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus. PMID: 22232668
    4. Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors PMID: 21897861
    5. BTC overexpression enhances glucose-induced insulin secretion in Mesenchyma Stem Cells PMID: 20836700
    6. Betacellulin protects from pancreatitis by activating stress-activated protein kinase. PMID: 20038432
    7. Excess of betacellulin exerts no deleterious effects on the structure or function of the male reproductive tract in mice. PMID: 19931240
    8. structure of the BTC gene PMID: 12031500
    9. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. PMID: 12773386
    10. Mice overexpressing BTC exhibit high early postnatal mortality, reduced body weight gain, impaired longitudinal growth, cataract, retinal and bone abnormalities, and lung disease. PMID: 16179416
    11. identified hitherto unknown effects of betacellulin (BTC) overabundance in reproduction and suggests BTC as a novel candidate protein for the modulation of fertility. PMID: 17914071
    12. role of BTC in the regulation of epidermal homeostasis, hair follicle morphogenesis and cycling, and wound angiogenesis PMID: 17960175
    13. Overexpression of BTC results in an EGFR-dependent upregulation of cortical bone mass in the appendicular skeleton of mice. PMID: 19049329
    14. Long-term BTC overabundance does not alter pancreatic islet structure and beta-cell mass, but enhances glucose-induced insulin secretion in vivo as well as in vitro. PMID: 19100309
    15. Reversal of streptozotocin-induced hyperglycemia by continouous supply of Btc. PMID: 19378417

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  • 亞細胞定位：
    [Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Found in several mouse tissues including kidney, uterus and liver, as well as in beta tumor cell line and MCF-7 cells. It is not detected in the brain.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:12223

    STRING: 10090.ENSMUSP00000112765

    UniGene: Mm.2024



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