Mouse Vascular cell adhesion molecule 1,VCAM-1 ELISA kit
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中文名稱:小鼠血管內(nèi)皮細(xì)胞粘附分子1(VCAM-1/CD106)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-E04754m
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規(guī)格:96T/48T
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價(jià)格:¥3800/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:小鼠血管內(nèi)皮細(xì)胞粘附分子1(VCAM-1/CD106)酶聯(lián)免疫試劑盒(CSB-E04754m)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的VCAM1含量。VCAM1(血管細(xì)胞粘附分子1)是一種細(xì)胞表面糖蛋白,屬于免疫球蛋白超家族。它主要在活化的內(nèi)皮細(xì)胞表面表達(dá),通過(guò)與白細(xì)胞表面的特定分子結(jié)合,調(diào)節(jié)炎癥反應(yīng)和白細(xì)胞遷移。VCAM1在免疫反應(yīng)和炎癥過(guò)程中發(fā)揮重要作用,其表達(dá)增加與多種免疫性疾病和癌癥的進(jìn)展密切相關(guān)。研究顯示,VCAM1通過(guò)調(diào)節(jié)小膠質(zhì)細(xì)胞的功能和Aβ的清除,在阿爾茨海默病的發(fā)生發(fā)展中扮演關(guān)鍵角色。試劑盒檢測(cè)范圍為39.062 pg/mL-2500 pg/mL,靈敏度為29.649 pg/mL。適用于體外研究血管內(nèi)皮細(xì)胞活化狀態(tài)、炎癥反應(yīng)機(jī)制、藥物干預(yù)效果評(píng)估等科研領(lǐng)域,為心血管疾病、免疫調(diào)控及腫瘤微環(huán)境等領(lǐng)域的機(jī)制研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名:Vcam1; Vcam-1; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD antigen CD106
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縮寫(xiě):
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, cell culture supernates, tissue homogenates
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檢測(cè)范圍:39.062 pg/mL-2500 pg/mL
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靈敏度:29.649 pg/mL
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長(zhǎng):450 nm
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研究領(lǐng)域:Cardiovascular
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of mouse VCAM-1/CD106 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
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標(biāo)準(zhǔn)曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Lead-induced actin polymerization aggravates neutrophil extracellular trap formation and contributes to vascular inflammation Q Nong, Y Wu, S Liu, Y Tang, J Wu, H Huang,Ecotoxicology and Environmental Safety,2025
- The synergistic effect of Ficus carica nanoparticles and Praziquantel on mice infected by Schistosoma mansoni cercariae NA El-Attar, MR El-Sawi, EA El-Shabasy,Scientific Reports,2024
- Estimation the Effect of Ficus carica Active components' Nanoparticles on Mice Infected by Schistosomal cercariae and treated with praziquantel NA El,/,2024
- Wenyang Huazhuo Tongluo formula alleviates pulmonary vascular injury and downregulates HIF-1α in bleomycin-induced systemic sclerosis mouse model K Li,BMC complementary medicine and therapies,2022
- A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium L Zhou,Oxidative Medicine and Cellular Longevity,2020
- MicroRNA-29a-3p Reduces TNFa-Induced Endothelial Dysfunction by Targeting Tumor Necrosis Factor Receptor X Deng,Mol Ther Nucleic Acids,2020
- Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway F Wei,Aging (Albany NY),2020
- MicroRNA-29a-3p reduces TNFα-induced endothelial dysfunction by targeting tumor necrosis factor receptor 1 Deng X, et al,Molecular Therapy-Nucleic Acids,2019
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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最新研究進(jìn)展:VCAM1是一種黏附分子,參與細(xì)胞黏附和遷移過(guò)程,已被證實(shí)與許多疾病的發(fā)生和發(fā)展有關(guān),如動(dòng)脈粥樣硬化和腫瘤的形成。最新的研究表明,VCAM1可能參與心血管疾病的發(fā)生和發(fā)展,并被認(rèn)為是一種治療心血管疾病的潛在靶點(diǎn)。此外,VCAM1的水平還可以作為某些疾病的診斷和預(yù)后標(biāo)志物。
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功能:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
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亞細(xì)胞定位:[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.
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組織特異性:Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
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數(shù)據(jù)庫(kù)鏈接:
STRING: 10090.ENSMUSP00000029574
UniGene: Mm.440909
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