在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Mouse Uromodulin(UMOD) ELISA kit

  • 中文名稱:
    小鼠尿調節蛋白(UMOD)酶聯免疫試劑盒
  • 貨號:
    CSB-EL025616MO
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠尿調節蛋白(UMOD)酶聯免疫試劑盒(CSB-EL025616MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的UMOD含量。UMOD即尿酸調節蛋白,它在腎臟生理中發揮重要作用。研究發現,UMOD基因變異與一些腎臟疾病如多囊腎病、高血壓等相關。其作用機制可能涉及調節腎小管對電解質的重吸收、影響腎臟局部血流動力學等,深入研究UMOD有助于揭示腎臟疾病發病機制。試劑盒檢測范圍為6.25 ng/mL-400 ng/mL,該產品廣泛用于小鼠腎臟功能研究、泌尿系統疾病模型建立(如慢性腎病、高血壓模型)及藥物干預實驗中UMOD動態變化的監測,可為腎臟生理機制探索、病理模型驗證及治療策略開發提供可靠數據支持本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Umod ELISA Kit; Uromodulin ELISA Kit; Tamm-Horsfall urinary glycoprotein ELISA Kit; THP) [Cleaved into: Uromodulin ELISA Kit; secreted form] ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    6.25 ng/mL-400 ng/mL
  • 靈敏度:
    1.56 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Others
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
  • 基因功能參考文獻:
    1. these data support THP as an important negative regulator of neutrophil activation in the urinary tract, with dual functions to counteract bacterial colonization and suppress excessive inflammation within the urinary tract PMID: 28829050
    2. this study shows that uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells PMID: 28992252
    3. results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses PMID: 29145399
    4. Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation. PMID: 28990932
    5. Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis. PMID: 28437467
    6. we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 axis and systemic neutrophilia. PMID: 25556169
    7. AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS may contribute to its anti-inflammatory effects. PMID: 23941548
    8. UMOD upregulates TRPV5 by decreasing caveolin-1 dependent endocytosis of TRPV5. PMID: 23466996
    9. UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha on NKCC2A expression, making UMOD an important determinant of blood pressure control. PMID: 24324041
    10. Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney. PMID: 24185693
    11. Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after. PMID: 23389456
    12. Quercetin has the uricosuric and nephroprotective actions mediated by regulating the expression levels of renal organic ion transporters and UMOD. PMID: 21909718
    13. a unifying model that underscores the role of THP as a major regulator of renal and systemic immunity. PMID: 22451664
    14. Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones. PMID: 22117067
    15. Deletion of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression showed strong expression of HIF-1alpha in thick ascending limb. PMID: 21921145
    16. THP-null mouse may have a distal tubular defect and thus mimics ileostomy patients with low urine volumes and acidic urine. PMID: 21063698
    17. THGP modulation of ROMK function confers a new role of THGP on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2/GCKD patients. PMID: 21081491
    18. These data clearly demonstrate a gain-of-toxic function of uromodulin mutations providing insights into the pathogenetic mechanism of the disease. PMID: 20472742
    19. Normal Tamm-Horsfall protein (THP) plays an important role in defending the urinary system against calcification. Reduced expression and/or decreased function of THP could contribute to nephrolithiasis. PMID: 20591941
    20. proximal 5'-flanking sequence is sufficient to drive the kidney-specific expression of a heterologous reporter gene PMID: 11880321
    21. potential THP defects, either quantitative or qualitative, could predispose the urinary bladder to bacterial infections PMID: 14665435
    22. THP serves as a soluble receptor for type 1 fimbriated E. coli and helps eliminate bacteria from the urinary tract. PMID: 14871399
    23. THP is a critical urinary defense factor and its deficiency could be an important contributing factor in nephrolithiasis PMID: 15327412
    24. Tamm-Horsfall glycoprotein plays an important regulatory role in the kidney PMID: 15522986
    25. The genes encoding pre-pro-epidermal growth factor (pre-pro-EGF) and Tamm-Horsfall protein (THP)/uromodulin were aberrantly expressed in the kidneys of COX-2 -/- mice at all stages of their development. PMID: 15741608
    26. Whole urine from osteopontin, Tamm-Horsfall protein , or double-null mice all possessed a dramatically reduced ability to inhibit the adhesion of calcium oxalate monohydrate crystals to renal epithelial cells PMID: 17898038
    27. Urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain. PMID: 18375198
    28. The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens. PMID: 18830570
    29. Letter: Tamm-Horsfall protein knockout mice have increased stress induced micturition. PMID: 19214995
    30. Umod might act as a gain-of-toxic-function mutation PMID: 19692485

    顯示更多

    收起更多

  • 亞細胞定位:
    [Uromodulin, secreted form]: Secreted.; Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane.
  • 組織特異性:
    Detected in urine (secreted form). Detected in kidney thick ascending limb epithelial cells (at protein level).
  • 數據庫鏈接:


主站蜘蛛池模板: 99视频在线精品免费观看6| 特黄三级又爽又粗又大| 色婷婷亚洲一区二区三区| 亚洲欧美乱综合图片区小说区| 粗大的内捧猛烈进出| 亚洲国产成人久久综合一区| 99久久久无码国产精品古装| 国产亚洲综合欧美视频| 亚洲精品卡一卡三卡四卡乱码| 欧美野性肉体狂欢大派对| 成人午夜福利视频镇东影视| 久久se精品一区精品二区| 中文字幕乱码久久午夜不卡| 精品无码专区亚洲| 老熟妇仑乱一区二区视頻| 国产精品多人p群无码| 欧美肥婆性猛交xxxx| 亚洲天堂在线观看完整版| 午夜福利伦伦电影理论片在线观看 | 国产成人欧美日本在线观看| 亚州性无码不卡免费视频| 成视频年人黄网站免费视频| 久久精品免费一区二区| 久久综合给合久久狠狠狠97色69| 欧美综合乱图图区乱图图区| 日本大香伊一区二区三区| 中国孕妇变态孕交xxxx| 久久99亚洲网美利坚合众国| 伊人伊成久久人综合网996| 欧美日韩精品一区二区在线观看| 成人做爰69片免费看网站| 精品国产综合成人亚洲区| 日本工口里番无遮█彩色| 疯狂的欧美乱大交| 国产激情无码一区二区| av天堂中av世界中文在线播放| 欧美大波少妇在厨房被| 欧美一区二区三区红桃小说| 97午夜理论片在线影院| 国产精品高潮露脸在线观看| 无码人妻av一区二区三区波多野|