在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Mouse Tumor necrosis factor ligand superfamily member 4(TNFSF4) ELISA kit

  • 中文名稱(chēng):
    小鼠腫瘤壞死因子配體超家族成員4(TNFSF4)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-EL023994MO
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠腫瘤壞死因子配體超家族成員4(TNFSF4)酶聯(lián)免疫試劑盒(CSB-EL023994MO)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的TNFSF4含量。TNFSF4是一個(gè)重要靶點(diǎn)。它是腫瘤壞死因子超家族成員,在免疫調(diào)節(jié)等生理過(guò)程中起關(guān)鍵作用。研究發(fā)現(xiàn)其異常表達(dá)與自身免疫疾病、腫瘤等多種疾病相關(guān)。目前圍繞其信號(hào)通路、與受體相互作用等機(jī)制研究,有望為相關(guān)疾病治療提供新方向。試劑盒檢測(cè)范圍為15.6pg/mL-1000pg/mL,適用于免疫調(diào)控機(jī)制研究、炎癥性疾病動(dòng)物模型評(píng)估、腫瘤免疫微環(huán)境分析等科研場(chǎng)景,也可用于藥物開(kāi)發(fā)過(guò)程中靶向TNFSF4通路的干預(yù)效果驗(yàn)證。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名:
    Tnfsf4; Ox40l; Txgp1l; Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD antigen CD252
  • 縮寫(xiě):
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類(lèi)型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測(cè)范圍:
    15.6pg/mL-1000pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Others
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
  • 基因功能參考文獻(xiàn):
    1. these findings demonstrate the utility of soluble OX40 L and JAG1 to induce TCR-independent regulatory T-cells proliferation PMID: 28045060
    2. The OX40L expression is induced on the bronchiolar progenitors for the antiviral immunity during the infectious process. However, these defense-like host responses lead to more extensive infection with the influenza virus owing to the induced OX40L with alpha-2,6 sialic acid modification, which augments the interaction with the viral hemagglutinin. PMID: 26976612
    3. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33 PMID: 26100084
    4. intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4(+) Th cell-intrinsic IL-4 program that is controlled by DC OX40L, and not by NKT, gammadelta T, or ILC cells. PMID: 24781052
    5. a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation. PMID: 25839234
    6. The majority of transferred CD40L(-/-) T cells in Rag-1(-/-) B6 mice were differentiated to CD44(high). PMID: 24254032
    7. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice. PMID: 25002484
    8. we identify a previously unknown role for OX40L in steady-state bone homeostasis PMID: 24469824
    9. Data indicate that OX40L contributes to both the development of Th2 cells and secondary Th2 responses induced by KLH-pulsed CD8- cDCs in vivo. PMID: 24462862
    10. These results showed a critical role for OX40L- and Jagged1-induced cosignaling in GM-BMDC-induced Treg expansion. PMID: 23630352
    11. engagement of OX40L selectively suppresses Fyn-initiated signals required for MC degranulation and serves to limit immediate hypersensitivity PMID: 22564682
    12. Present findings suggest a role for the OX40L-derived immune response and epistatic genetic effect in immune-mediated pathogenesis of PAH. PMID: 22171643
    13. The vascular OX40/OX40L system plays an important role in the formation of vasa vasorum and subsequent atherosclerosis. PMID: 20584752
    14. our data provide an in vivo role for the OX40/OX40L system in the innate immune response during polymicrobial sepsis PMID: 20844189
    15. Tumor necrosis factor ligand OX40L-expressing Langerhans cells play a mandatory role in the induction of regulatory T cells in ultraviolet B immunosuppressed mice. PMID: 20400709
    16. Constitutive interaction of OX40 ligand with OX40 during immune regulation is linked to the development of autoimmune-like diseases in OX40L-transgenic mice. PMID: 12370402
    17. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion. PMID: 12668647
    18. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. PMID: 12672051
    19. Engagement of OX40 by an OX40L:Ig fusion protein drives IFN-gamma production by CD4+ T cells and reduces eosinophilia and the burden of Cryptococcus neoformans in the lung. PMID: 12794142
    20. A null allele at OX40L completely prevents diabetes development in nonobese diabetic mice and strongly reduces its incidence in a T cell receptor transgenic model, while paradoxically sustaining the long-term progression to autoimmune destruction. PMID: 14662903
    21. OX40-OX40L interaction affects both regulatory and nonregulatory T cells by influencing suppression, susceptibility to suppression, and clonal expansion. PMID: 15004159
    22. OX40 and OX40L interactions form a late checkpoint in diabetes development and are realistic targets for therapeutic intervention. PMID: 15368274
    23. neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient PMID: 16920944
    24. OX40 ligand (OX40L) is required for optimal T helper (Th) type 2 cell priming and memory Th2 responses in vivo; dependence upon OX40L is predominantly due to the provision of signaling through OX40 rather than retrograde signaling dendritic cells. PMID: 17785785
    25. These results show a critical role for OX40L on DCs, via binding to OX40 on NKT cells and CD4+ T cells, in the induction of antitumor immunity in tumor-bearing mice. PMID: 17975668
    26. OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses. PMID: 18060034
    27. Th2 skewing is mediated by OX40L PMID: 18354165
    28. TNFSF4 gene is identified as a potential candidate Sjogren's syndrome susceptibility gene. PMID: 19032782
    29. OX40L may play an important role in the early phase of T cell activation and proliferation PMID: 19663699

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Tumor necrosis factor family
  • 數(shù)據(jù)庫(kù)鏈接:

    KEGG: mmu:22164

    STRING: 10090.ENSMUSP00000028024

    UniGene: Mm.4994



主站蜘蛛池模板: 日韩av无码一区二区三区无码 | 丰满妇女强制高潮18xxxx| 无码国产精品一区二区色情男同| 国语国产精精品国产国语清晰对话| 亚洲国产一区二区三区在观看| 久久国内精品自在自线图片| 久久久久人妻一区二区三区| 久久久久无码精品亚洲日韩| 免费国产午夜理论片不卡 | 人人人爽人人爽人人av| 在线观看国产丝袜控网站| 国产a∨精品一区二区三区不卡| 高h纯肉无码视频在线观看| 久久久久久久岛国免费观看 | 国产成a人亚洲精品无码久久网| 好爽别插了无码视频| 女人被黑人躁得好爽视频| 成人自慰女黄网站免费大全| 老头把我添高潮了a片| 亚洲第一av网站| 国产精品性夜天天拍拍2021| 精品伊人久久久大香线蕉下载 | 亚洲日韩一中文字暮av| 国产成人亚洲综合| 成在人线av无码免观看午夜网 | av天堂久久精品影音先锋| 亚洲裸男gv网站| 国产尤物精品视频| 久久老子午夜精品无码怎么打| 中文字幕人妻丝袜成熟乱| 亚洲色大成网站www永久男同| 国产精品亚洲综合一区在线观看| 久久99精品久久久久久清纯| 人妻精品久久久久中文字幕69| 精品人妻码一区二区三区| 国产美女爽到喷出水来视频| 爽到高潮无码视频在线观看| 成熟丰满熟妇av无码区| 少妇白浆呻吟爽| 综合自拍亚洲综合图区高清| 国产午夜亚洲精品不卡在线观看|