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  4. Mouse Thyroglobulin,TG ELISA Kit

Mouse Thyroglobulin,TG ELISA Kit

  • 中文名稱：
    小鼠甲狀腺球蛋白(TG)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08241m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠甲狀腺球蛋白(TG)酶聯(lián)免疫試劑盒（CSB-E08241m）為競(jìng)爭(zhēng)法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的TG含量。試劑盒檢測(cè)范圍為10 ng/mL-160 ng/mL，適用于甲狀腺疾病模型研究、自身免疫性甲狀腺炎機(jī)制探索、甲狀腺代謝調(diào)控實(shí)驗(yàn)等科研場(chǎng)景，為甲狀腺相關(guān)分子機(jī)制研究及藥物干預(yù)效果評(píng)估提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    Tg ELISA Kit; Tgn ELISA Kit; Thyroglobulin ELISA Kit; Tg ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    10 ng/mL-160 ng/mL
  • 靈敏度：
    10 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Metabolism
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse TG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 90    
    Range % 85-100    
    1:2 Average % 89    
    Range % 82-100    
    1:4 Average % 93    
    Range % 88-100    
    1:8 Average % 95    
    Range % 89-105    
  • 回收率：
    The recovery of mouse TG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 97 92-110    
    EDTA plasma (n=4) 95 89-100    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average 　    
    160 0.165 0.170 0.168 　    
    80 0.276 0.271 0.274 　    
    40 0.504 0.499 0.502 　    
    20 1.008 1.034 1.021 　    
    10 2.055 2.029 2.042 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules.
  • 基因功能參考文獻(xiàn)：
    1. Findings suggest that coumestrol treatment may have some beneficial actions against thyroid-specific thyroglobulin (Tg) autoantibody production in the development of autoimmune thyroiditis through suppression of Th1 response. PMID: 27384679
    2. these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT. PMID: 24879795
    3. Final acquisition of secretory competence includes conformational maturation in the interval between linker and hinge segments of region I of thyroglobulin. PMID: 21816825
    4. The results showed that thyroglobulin message or protein is not expressed in placenta, decidua, or ovary in any stages of pregnancy. PMID: 20236260
    5. Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO. PMID: 20573721
    6. These results indicate that Runx2 deficiency in mice causes decreased Tg expression and a novel type of hypothyroidism. PMID: 20375239
    7. Development of iodine-accelerated autoimmune thyroiditis in NOD.H2h4 mice is not associated with enhanced iodine organification or differential B- or T-cell responses to iodinated determinants in Tg. PMID: 20687399
    8. specific properties of distinct Tg ChEL mutants may result in distinct patterns of Tg monomer folding PMID: 20353937
    9. Five novel autoimmune thyroiditis-causing T cell epitopes of thyroglobulin (Tgn) have been delineated and mapped with an algorithm that predicts Tgn immunopathogenic peptides containing I-A(k)-binding motifs. PMID: 12391254
    10. iodotyrosyl formation in normal thyroglobulin confers pathogenic potential to certain peptides that may otherwise remain innocuous and undetectable by conventional mapping methods PMID: 16547286
    11. Tg could initiate glomerular injury by reproducing the actions of TGF-beta1 in the mesangial cell. PMID: 17495424
    12. Data indicate that the R19K mutation induces local misfolding in the amino-terminal domain of Tg that has global effects on Tg transport and thyroid hormonogenesis. PMID: 17916655
    13. Together these results suggest that a unique low molecular weight variant of Tg is expressed in the kidney, where it could serve both physiological and pathological roles, including that of an autoantigen. PMID: 19716808

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  • 相關(guān)疾病：
    Defects in Tg are the cause of some forms of goiter. Goiter is an enlargement of the thyroid gland. The variant Pro-2283 exhibits a defect in exit from the endoplasmic reticulum.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 組織特異性：
    Specifically expressed in the thyroid gland.
  • 數(shù)據(jù)庫(kù)鏈接：


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