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  4. Mouse Secretoglobin family 3A member 2(SCGB3A2) ELISA kit

Mouse Secretoglobin family 3A member 2(SCGB3A2) ELISA kit

  • 中文名稱：
    小鼠分泌球蛋白家族3A成員2(SCGB3A2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL020819MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠分泌球蛋白家族3A成員2(SCGB3A2)酶聯免疫試劑盒（CSB-EL020819MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的SCGB3A2含量。SCGB3A2（分泌性杯狀細胞相關蛋白 3A2）是重要的肺上皮細胞分泌蛋白。它常作為肺臟相關疾病的潛在靶點。研究機制方面，主要聚焦其在肺組織穩態維持、炎癥反應調控等過程中的作用，探索通過干預它來治療如肺纖維化等疾病。試劑盒檢測范圍為9.4 pg/mL-600 pg/mL，適用于小鼠模型中肺纖維化、哮喘等呼吸道疾病的分子機制探索、藥物干預效果評估及SCGB3A2表達調控研究，支持科研人員高效開展體外實驗。本產品僅限用于科學研究領域，不適用于其他用途。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Scgb3a2 ELISA Kit; Pnsp1 ELISA Kit; Ugrp1 ELISA Kit; Secretoglobin family 3A member 2 ELISA Kit; Pneumo secretory protein 1 ELISA Kit; PnSP-1 ELISA Kit; Uteroglobin-related protein 1 ELISA Kit
  • 縮寫：
    SCGB3A2
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    9.4 pg/mL-600 pg/mL
  • 靈敏度：
    2.35 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Epigenetics and Nuclear Signaling
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse SCGB3A2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 87
    Range % 82-91
    1:2 Average % 94
    Range % 89-98
    1:4 Average % 107
    Range % 103-110
    1:8 Average % 110
    Range % 104-114
  • 回收率：
    The recovery of mouse SCGB3A2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 91-99
    EDTA plasma (n=4) 103 98-108
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    600 2.511 2.468 2.490 2.318
    300 1.672 1.699 1.686 1.514
    150 1.015 0.989 1.002 0.830
    75 0.594 0.586 0.590 0.418
    37.5 0.403 0.412 0.408 0.236
    18.75 0.292 0.289 0.291 0.119
    9.4 0.218 0.207 0.213 0.041
    0 0.171 0.173 0.172 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
  • 基因功能參考文獻：
    1. These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. PMID: 27820933
    2. The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. PMID: 26559674
    3. SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. PMID: 26178733
    4. The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. PMID: 25242865
    5. SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID: 24514953
    6. Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation PMID: 21478551
    7. Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
    8. UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. PMID: 12915772
    9. results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
    10. UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. PMID: 15531759
    11. To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. PMID: 18535256
    12. C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development PMID: 18632661
    13. SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, UGRP subfamily
  • 組織特異性：
    Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level). Expressed in club/Clara cells of the bronchioles. Also detected in the anterior and posterior lobes of the pituitary gland where i
  • 數據庫鏈接：


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