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Mouse Secreted frizzled-related protein 3(FRZB) ELISA kit

  • 中文名稱:
    小鼠分泌卷曲相關蛋白3(FRZB)酶聯免疫試劑盒
  • 貨號:
    CSB-EL009008MO
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠分泌卷曲相關蛋白3(FRZB)酶聯免疫試劑盒(CSB-EL009008MO)檢測樣本中的FRZB含量。FRZB是一種參與骨發育調節的分泌蛋白,其缺陷與女性特定骨質疏松癥相關。研究顯示,FRZB通過調節Wnt/β-catenin信號通路影響骨髓炎,并參與多種疾病的調節,如骨關節炎、心血管疾病和癌癥。適用于體外實驗條件下探索FRZB在骨骼疾病、腫瘤機制或組織再生等方向的分子功能,為相關基礎研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Frzb ELISA Kit; Fiz ELISA Kit; Fre ELISA Kit; Frzb1 ELISA Kit; Sfrp3 ELISA Kit; Secreted frizzled-related protein 3 ELISA Kit; sFRP-3 ELISA Kit; Frezzled ELISA Kit; Fritz ELISA Kit; Frizzled-related protein 1 ELISA Kit; FrzB-1 ELISA Kit
  • 縮寫:
    FRZB
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
  • 基因功能參考文獻:
    1. particle-induced inhibition on cell proliferation, differentiation and FRZB expression were all reversed by miR-130b silence PMID: 28382864
    2. Stable overexpression of Frzb in MC3T3-E1 cells increased calcium deposition and osteoblast markers compared with control. Western blot analysis showed that the increased osteogenesis was associated with reduced canonical, but increased non-canonical Wnt signaling. PMID: 26927515
    3. an inverse septal-to-temporal increase in the expression of sfrp3 that emerges during postnatal development, is reported. PMID: 26337530
    4. The spatiotemporally dynamic expression ofsFRP3 strongly suggests that sFRP3 has potential functions in the sensory neuron genesis and sensory circuitry formation. PMID: 23827310
    5. Our results suggest that FrzB may have a protective role on cartilage degradation and matrix metalloproteinase induction in mouse chondrocytes PMID: 24984954
    6. left ventricles from post-MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts PMID: 24330105
    7. Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice. PMID: 23207650
    8. Study identifies sFRP3 as an inhibitory niche factor from local mature dentate granule neurons that regulates multiple phases of adult hippocampal neurogenesis. PMID: 23395446
    9. Data indicate an important role for frizzled-related protein (Frzb) in joint homeostasis and highlight the complex biology of WNT signaling in the joint. PMID: 22264237
    10. Secreted Frizzled-related proteins (sFrps) are expressed in the postnatal cerebral cortex in regional and lamina patterns in the major subdivisions of the cerebral cortex: the olfactory bulb, the hippocampal formation, and the neocortex. PMID: 15116386
    11. sFRP3 may stimulate differentiation through a beta-catenin-independent pathway in addition to its previously known function as a decoy receptor for Wnt's PMID: 15312239
    12. Loss of Frzb may contribute to cartilage damage by increasing the expression and activity of MMPs, in a WNT-dependent and WNT-independent manner. This may contribute to the development of osteoarthritis. PMID: 18050203
    13. Our findings support Wnt5a and sfrp3 as regulators of otic capsule formation in the developing mouse inner ear. PMID: 18991062

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Secreted frizzled-related protein (sFRP) family
  • 組織特異性:
    Expressed in kidney, brain, testis. Weak expression in spleen and heart.
  • 數據庫鏈接:


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