在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

  • 中文名稱：
    小鼠清道夫受體富含半胱氨酸1蛋白M130(CD163)酶聯免疫試劑盒
  • 貨號：
    CSB-EL004882MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠清道夫受體富含半胱氨酸1蛋白M130(CD163)酶聯免疫試劑盒（CSB-EL004882MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CD163含量。CD163是一種清道夫受體，主要在單核-巨噬細胞膜上表達，具有清除血紅蛋白-觸珠蛋白復合物的功能。它既是巨噬細胞活化的標志物，也具有抗炎、抗氧化作用，與腫瘤、肝衰竭等疾病的發生發展密切相關。試劑盒檢測范圍為0.93 ng/ml-60ng/ml，靈敏度為0.23 ng/ml。適用于炎癥模型研究、免疫調控機制探索、血液相關疾病動物實驗等科研場景，能夠有效評估巨噬細胞活化狀態或病理條件下CD163的動態變化，為心血管疾病、代謝綜合征及感染性疾病的基礎研究提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Cd163 ELISA kit; M130Scavenger receptor cysteine-rich type 1 protein M130 ELISA kit; CD antigen CD163) [Cleaved into: Soluble CD163 ELISA kit; sCD163)] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.9 ng/ml-60 ng/ml
  • 靈敏度：
    0.23 ng/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse CD163 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    97

    Range %

    91-103

    1:2

    Average %

    87

    Range %

    80-96

    1:4

    Average %

    87

    Range %

    84-91

    1:8

    Average %

    95

    Range %

    91-99

  • 回收率：

    The recovery of mouse CD163 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    88

    82-95

    EDTA plasma (n=4)

    92

    87-96

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    60

    2.306

    2.233

    2.270

    2.206

    30

    1.356

    1.275

    1.316

    1.252

    15

    0.742

    0.752

    0.747

    0.683

    7.5

    0.481

    0.491

    0.486

    0.422

    3.75

    0.264

    0.275

    0.270

    0.206

    1.8

    0.207

    0.205

    0.206

    0.142

    0.9

    0.105

    0.100

    0.103

    0.039

    0

    0.063

    0.065

    0.064

    　

  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展：
    CD163是一種單核細胞的受體，可參與調節細胞的炎癥和免疫反應。最新研究表明，CD163在多種疾病的發生發展中起重要作用，如肝病、炎癥性腸病、肺炎、骨質疏松等。此外，CD163還可能成為腫瘤治療的新靶點，相關研究正在進行中。
  • 功能：
    Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.; After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
  • 基因功能參考文獻：
    1. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia PMID: 26376364
    2. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes. PMID: 27354410
    3. During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation. PMID: 26242746
    4. Data indicate an essential substrate motif for ADAM17-mediated CD163 and proTNF-alpha cleavage in macrophages. PMID: 24275664
    5. alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. PMID: 22807450
    6. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. PMID: 21427223
    7. Assignment of the CD163 antigen to mouse chromosome 6 band F2. PMID: 12698011

    顯示更多

    收起更多

  • 亞細胞定位：
    [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品久久国产精麻豆99网站| 亚洲人成无码网www电影麻豆| 国产精品内射视频免费| 7777奇米成人狠狠成人影视| 久久精品青草社区| 国产精品美女久久久久久| 激情综合亚洲色婷婷五月| 国模大尺度福利视频在线| 国产午夜精品一区二区三区不卡| 亚洲精品成人片在线观看精品字幕 | 被黑人猛躁10次高潮视频| 极品少妇被啪到呻吟喷水| 国产高清在线精品一本大道| 天天爽天天狠久久久综合麻豆 | 成人免费视频一区二区| 日本人又黄又爽又色的视频| 日韩不卡1卡2卡三卡2021精品推荐| 黑人巨茎大战白人美女| 狠狠色丁香久久婷婷综合五月| 久久综合久久自在自线精品自| 免费的av网站手机版| 久久精品国产99国产精品亚洲| 欧美不卡一卡二卡三卡| 18禁黄网站禁片免费观看女女| 天天爽夜夜爽人人爽曰| 国产精品岛国久久久久| 日韩美女自卫慰黄网站| 樱花草视频www日本韩国| 亚洲成a人片在线不卡一二三区| 国产亚洲精品ae86| 久久精品中文字幕第一页| 蜜桃臀无码内射一区二区三区| 欧美一区二区三区视频在线观看| 国产农村毛卡片| 少妇人妻无码专区视频| 巨胸美乳无码人妻视频| 亚洲人成77777在线播放网站 | 日本真人边吃奶边做爽免费视频 | 黄网在线观看免费网站| 免费观看的av在线播放| 免费无码在线播放av|