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Mouse Pentraxin-related protein PTX3(PTX3) ELISA kit

  • 中文名稱:
    小鼠Pentraxin相關蛋白PTX3(PTX3)酶聯免疫試劑盒
  • 貨號:
    CSB-EL019079MO
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠Pentraxin相關蛋白PTX3(PTX3)酶聯免疫試劑盒(CSB-EL019079MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的PTX3含量。PTX3屬于正五聚蛋白家族成員,在天然免疫防御等過程中起重要作用。研究機制方面,它可作為模式識別分子參與病原體識別、補體激活等;還在炎癥反應、血管穩態等方面展現調控作用,其異常表達與多種疾病發生發展相關。試劑盒檢測范圍為0.313 ng/mL-20 ng/mL,靈敏度為0.210 ng/mL。適用于科研領域探究炎癥性疾病機制、評估感染模型免疫應答、心血管損傷修復研究及腫瘤微環境分析等方向。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Ptx3 ELISA Kit; Tsg14 ELISA Kit; Pentraxin-related protein PTX3 ELISA Kit; Pentaxin-related protein PTX3 ELISA Kit; Tumor necrosis factor-inducible gene 14 protein ELISA Kit; TSG-14 ELISA Kit
  • 縮寫:
    PTX3
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.313 ng/mL-20 ng/mL
  • 靈敏度:
    0.210 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展:
    PTX3是一種與免疫和炎癥反應相關的蛋白質。它在很多不同的疾病中都被發現有重要的作用,包括感染、心血管疾病、炎癥性腸病和腫瘤等。研究人員正在進一步探索PTX3的具體作用機制,以及它在臨床上作為潛在的生物標志物的應用前景。這些研究對于我們更好地理解這個蛋白的功能,以及對相關疾病的預防和治療有重要的意義。
  • 功能:
    Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
  • 基因功能參考文獻:
    1. determined that PTX3 was an important moderator of obesity; inflammation during pregnancy could lead to a significant increase in the levels of the inflammatory factor PTX3. PMID: 28770376
    2. Alcoholic intoxication suppresses pentraxin 3 expression and contributes to exacerbation of sepsis. PMID: 28965650
    3. increased susceptibility to Aspergillus fumigatus correlates with downregulation of Ptx3 expression in calcineurin-deficient mice PMID: 27301880
    4. Pneumococcal toxin pneumolysin was responsible for PTX3 expression and upregulated PTX3 expression via JNK MAPK signaling. These data implicate PTX3 as a novel therapeutic target for the control of acute inflammation by pneumococcus. PMID: 28864415
    5. PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for marginal zone B cells. PMID: 27621420
    6. PTX3 levels increase in the airways of patients with severe asthma and OVA-exposed mice. Deletion of PTX3 results in enhanced inflammation, airway hyper-responsiveness, and mucus production on OVA sensitization and challenge.On OVA exposure, CD4 T cells from Ptx3-/- mice exhibit an enhanced survival in contrast to Ptx3+/+ mice PMID: 27567326
    7. PTX3 plays a non-redundant role in resistance against microbial pathogens and in the regulation of inflammation. (Review) PMID: 26650391
    8. PTX3 produced from bone marrow-derived cells plays a crucial role in cardiac protection. PMID: 26470821
    9. PTX3 expression is elevated in spinal cords during chronic relapsing EAE in Biozzi ABH mice, but the EAE severity and time course in PTX3-deficient mice did not differ from WT mice PMID: 26576501
    10. Cardioprotective function of immunoproteasome-dependent PTX3 expression revealed a crucial mechanism of the stress-induced damage response in myocardial inflammation. PMID: 26578407
    11. Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury. PMID: 25342475
    12. Neisseria meningitidis is recognized by PTX3, which serves as an endogenous adjuvant against meningococcal infection. PMID: 25786110
    13. These data suggest that the relative levels of SAP and PTX3 present at sites of fibrosis may have a significant effect on the ability of monocytes to differentiate into fibrocytes. PMID: 25774777
    14. our study identified a previously undescribed pathogenic role of PTX3 during virus infection PMID: 25695775
    15. PTX3 has a role in tissue remodeling and repair, involved in matrix and microbial recognition, which may be common, ancestral features of the humoral arm of innate immunity PMID: 25964372
    16. The host-protective effects of PTX3 in sepsis are a result of its coaggregation with histones rather than its ability to mediate pattern recognition. PMID: 25227610
    17. PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic oncosuppressor gene in mouse and man by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation. PMID: 25679762
    18. Results suggests that miR-224 regulates Ptx3 under normal conditions. PMID: 24470395
    19. 10-fold-greater PTX3 levels were observed. PMID: 25001601
    20. The PTX3-driven increase in the osteoclastogenic potential of precursor osteoblasts (pOB) appears to be mediated by the effect of PTX3 on pOB RANKL production. PMID: 24664887
    21. miR-224 may affect ovulation and subsequent embryo development by targeting Ptx3. PMID: 24145127
    22. gene-deficient mice show defective control of urinary tract infection and exacerbated inflammation PMID: 24745336
    23. PTX3 expression induced by proinflammatory signals after ischemic brain injury is a critical effector of edema resolution and glial scar formation. PMID: 24346689
    24. The decrease in PTX3 protein in the adipose tissue and skeletal muscles may partly contribute to obesity-induced insulin resistance in the skeletal muscles. PMID: 23442541
    25. Neonatal mice made less PTX3 than adult mice when exposed to E. coli lipopolysaccharides. PMID: 23863905
    26. PTX3 release from a subpopulation of intrarenal mononuclear phagocytes or delayed PTX3 treatment limits postischemic renal inflammation. Ptx3 loss-of-function mutations predispose to postischemic acute kidney injury and subsequent chronic kidney disease. PMID: 23325083
    27. The local inflammatory mediator pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction. PMID: 23372656
    28. Long pentraxin-3 is an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer. PMID: 23424081
    29. Endothelial PTX3 plays a pivotal role in the pathogenesis of ischemic acute kidney injury. PMID: 22895517
    30. PTX3 deficiency enhanced early infiltration of neutrophils and macrophages in the lung. PTX3 bound to MHV-1 and MHV-3 and reduced MHV-1 infectivity in vitro PMID: 22732935
    31. Assessment of pentraxin-3, an extracellular matrix protein essential for fertilization, by immunocytochemistry and Western blotting showed dramatically impaired secretion concurrent with endoplasmic reticulum stress. PMID: 22383462
    32. PTX3 located at the membrane of late apoptotic macrophages mediates their phagocytosis by phagocytes in a cell model of advanced atherosclerosis. PMID: 22173877
    33. data presented contribute to a better understanding of the pathophysiology of ventilator-induced lung injury by addressing the role of Ptx3 as a protein that exacerbates lung injury induced by high tidal volume ventilation PMID: 22425349
    34. TSG-6 reverts the inhibitory effects exerted by PTX3 on FGF2-mediated angiogenesis through competition of FGF2/PTX3 interaction. PMID: 22267482
    35. Dimer of the PTX3 is unable to rescue cumulus matrix organization, and that the tetrameric assembly of the protein is the minimal oligomeric state required for accomplishing this function. PMID: 21619930
    36. Loss-of-function mutations in the Ptx3 gene might represent a genetic risk factor for pulmonary (but not renal) manifestations of systemic lupus or other autoimmune diseases. PMID: 21637713
    37. The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. PMID: 21388349
    38. Cigarette smoke increases pulmonary PTX3 expression in an interleukin-1 dependent manner. PMID: 20920344
    39. molecular pathways involved in the opsonic activity of PTX3 PMID: 20829368
    40. PTX3 is a potential biomrker of acute lung injury PMID: 19921147
    41. Data point to a critical role of TSG-14 in controlling acute inflammatory response in part via the modulation of TNF-alpha expression. PMID: 12000727
    42. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. PMID: 12040004
    43. long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus PMID: 12432394
    44. Addition of rPTX3, to macrophages containing Zymosan increases in phagocytosis, which parallels that of Tg-derived macrophages, demonstrating the opsonin-like activity of PTX3. PMID: 14726497
    45. Results show that PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility. PMID: 14998931
    46. experiments suggest that PTX3 is an essential part of the ability of a host to deal with bacterial infection PMID: 16697676
    47. there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region PMID: 16769728
    48. PTX3 bound both MCMV and HMCV viruses, reduced viral entry and infectivity, and protected from MCMV primary infection and reactivation through the activation of IRF3 in dendritic cells via the TLR9/MyD88-independent viral recognition sensing pathway PMID: 16840729
    49. neutrophils serve as a reservoir, ready for rapid release, of the long PTX3, a key component of humoral innate immunity with opsonic activity PMID: 17389238
    50. Pentraxin 3 is an important member of the signaling network operative in implantation and decidualization. PMID: 17538075

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  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:


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