Mouse Neurogranin(NRGN) ELISA kit
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中文名稱:小鼠神經顆粒素(NRGN)酶聯免疫試劑盒
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貨號:CSB-EL016081MO
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規格:96T/48T
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價格:¥3600/¥2500
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其他:
產品詳情
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產品描述:小鼠神經顆粒素(NRGN)酶聯免疫試劑盒(CSB-EL016081MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的NRGN含量。NRGN(神經顆粒素)是一種神經元特異性的蛋白質,由位于11q24.2染色體上的基因編碼。它在突觸信號傳導中起重要作用,通過調節鈣調蛋白(CaM)的可用性來影響突觸可塑性和學習記憶。NRGN的表達與精神分裂癥、甲狀腺功能減退癥和阿爾茨海默病等疾病有關。研究顯示,NRGN通過鈣調蛋白依賴性調節神經元磷酸化蛋白質組,雙向調節突觸可塑性,對認知功能有重要影響。試劑盒檢測范圍為3.12 ng/mL-200 ng/mL,適用于神經發育、神經退行性疾病模型(如阿爾茨海默病或帕金森病)以及突觸功能相關的分子機制研究,能夠為探索認知功能障礙、藥物干預效果等科研方向提供定量數據支持。支持科研人員高效完成神經科學領域的蛋白表達水平分析。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:NrgnNeurogranin ELISA Kit; Ng ELISA Kit; RC3) [Cleaved into: NEUG(55-78)] ELISA Kit
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縮寫:NRGN
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:3.12 ng/mL-200 ng/mL
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靈敏度:0.78 ng/mL
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Neuroscience
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測定原理:quantitative
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測定方法:Sandwich
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數據處理:
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貨期:3-5 working days
相關產品
靶點詳情
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功能:Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning.
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基因功能參考文獻:
- The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling. PMID: 29225043
- The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. PMID: 25972176
- Neurogranin knockout mice are hyperactive and socially withdrawn. PMID: 22809330
- Ng expression in olfactory bulb is restricted to developmental stages suggesting activity-dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells. PMID: 22592880
- findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes. PMID: 21256930
- We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation PMID: 20693275
- Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms. PMID: 19827160
- Data show that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons. PMID: 19751214
- Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse PMID: 11912190
- Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms. PMID: 12655510
- calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3 PMID: 12859333
- NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices PMID: 12950461
- NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1-CA3. PMID: 15389613
- Results suggest that neurogranin oxidation plays a significant role in intracellular calcium homeostasis, essential for the activated signaling networks in learning and memory. PMID: 15469893
- Ng may promote a high [Ca2+]i by a "mass-action" mechanism; namely, the higher the Ng concentration, the more Ng-CaM complexes will be formed. PMID: 15564582
- These results suggest that neurogranin protein may be involved in the development of cerebral hypoxic preconditioning. PMID: 16182446
- Data suggest that parasagittal stripes of Purkinje cells express neurogranin, possibly from as early as embryonic day (E) 13 and definitively from E15, in a pattern that persists up to postnatal day 20. PMID: 16320235
- Neurogranin(Ng) gates neuronal signaling reactions involved in learning and memory. During environmental enrichment, these Ng-regulated reactions are also critical for enhancement of synaptic plasticity and cognitive functions. PMID: 16763030
- Recombinant mNg promotes SNP-induced cell death in human cells through an amplification of calcium-mediated signaling, which requires the interaction between CaM and IQ motif of Ng. PMID: 17389928
- phosphorylation of neurogranin (Ng) but not the calmodulin/Ng interaction plays an important role in ERK activation PMID: 17505539
- long-term enrichment for the aging Ng-/- mice may improve their cognitive function through an Ng-independent plasticity pathway PMID: 17671107
- Neurogranin may regulate, in addition to the Ca(2+)-CaM-dependent process, Ca(2+)-sensitive enzymes by influencing the buffering capacity of CaM and subsequently free Ca(2+) levels. PMID: 17959737
- The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. PMID: 19376211
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亞細胞定位:Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine.
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蛋白家族:Neurogranin family
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數據庫鏈接:
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