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  4. Mouse Interleukin 31(IL-31) ELISA Kit

Mouse Interleukin 31(IL-31) ELISA Kit

  • 中文名稱：
    小鼠白介素31(IL-31)酶聯免疫試劑盒
  • 貨號：
    CSB-E13660m
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠白介素31(IL-31)酶聯免疫試劑盒（CSB-E13660m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的IL31含量。IL31，即白介素31，是一種炎癥性細胞因子，主要由Th2細胞產生，通過IL31RA和OSMR受體復合物激活STAT3和STAT5等信號通路，參與皮膚免疫和炎癥性疾病，如特應性皮炎。其作用機制涉及皮膚屏障、神經生長和瘙癢調節。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于科研領域探究IL-31在炎癥模型、免疫調控實驗中的動態表達，或用于評估藥物干預對IL-31分泌的影響，可為皮膚病學、免疫學等基礎研究提供可靠數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Il31Interleukin-31 ELISA Kit; IL-31 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL-31 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %90
    Range %82-99
    1:2Average %97
    Range %87-105
    1:4Average %95
    Range %88-100
    1:8Average %90
    Range %82-98
  • 回收率：
    The recovery of mouse IL-31 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9793-104
    EDTA plasma (n=4)9990-106
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.886 2.846 2.866 2.702
    10002.347 2.336 2.342 2.178
    5001.559 1.602 1.581 1.417
    2500.897 0.878 0.888 0.724
    1250.532 0.557 0.545 0.381
    62.50.366 0.374 0.370 0.206
    31.250.262 0.245 0.254 0.090
    00.162 0.165 0.164 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.
  • 基因功能參考文獻：
    1. The serum levels of IL-33 and IL-31 were significantly up-regulated in both AR and allergic asthma patients compared with normal individuals. PMID: 30301503
    2. EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4-positive T cells. PMID: 28067314
    3. IL-31 increased the concentration of intracellular Ca(2+) ions in mouse keratinocytes. PMID: 29477033
    4. IL-31 elicits itch not only through direct action on primary sensory neurones, but also by inducing LTB4 production in keratinocytes. PMID: 28512667
    5. IL31 and its receptor, IL31RA, are highly expressed in various human and mouse cancer cell lines, as well as in tumor specimens from cancer patients. MC38 murine colon carcinoma cells depleted of IL31 exhibit an increase in invasive and migratory properties in vitro. PMID: 28147314
    6. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. PMID: 26198770
    7. IL-31 upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA expression in mice PMID: 25381841
    8. our results suggest a functional cooperation between NFAT1 and JunB in mediating IL-31 gene expression in CD4(+) T cells PMID: 25595785
    9. Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions. PMID: 21182835
    10. IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases PMID: 15184896
    11. IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung. PMID: 17353366
    12. -31 antibody reduces scratching behaviour in an atopic dermatitis-like murine model during the onset of clinical skin manifestations PMID: 19054054
    13. these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine. PMID: 19414760

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  • 亞細胞定位：
    Secreted.
  • 數據庫鏈接：


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