在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse Interleukin 31(IL-31) ELISA Kit

Mouse Interleukin 31(IL-31) ELISA Kit

  • 中文名稱：
    小鼠白介素31(IL-31)酶聯免疫試劑盒
  • 貨號：
    CSB-E13660m
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠白介素31(IL-31)酶聯免疫試劑盒（CSB-E13660m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的IL31含量。IL31，即白介素31，是一種炎癥性細胞因子，主要由Th2細胞產生，通過IL31RA和OSMR受體復合物激活STAT3和STAT5等信號通路，參與皮膚免疫和炎癥性疾病，如特應性皮炎。其作用機制涉及皮膚屏障、神經生長和瘙癢調節。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于科研領域探究IL-31在炎癥模型、免疫調控實驗中的動態表達，或用于評估藥物干預對IL-31分泌的影響，可為皮膚病學、免疫學等基礎研究提供可靠數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Il31Interleukin-31 ELISA Kit; IL-31 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL-31 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %90
    Range %82-99
    1:2Average %97
    Range %87-105
    1:4Average %95
    Range %88-100
    1:8Average %90
    Range %82-98
  • 回收率：
    The recovery of mouse IL-31 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9793-104
    EDTA plasma (n=4)9990-106
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.886 2.846 2.866 2.702
    10002.347 2.336 2.342 2.178
    5001.559 1.602 1.581 1.417
    2500.897 0.878 0.888 0.724
    1250.532 0.557 0.545 0.381
    62.50.366 0.374 0.370 0.206
    31.250.262 0.245 0.254 0.090
    00.162 0.165 0.164 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.
  • 基因功能參考文獻：
    1. The serum levels of IL-33 and IL-31 were significantly up-regulated in both AR and allergic asthma patients compared with normal individuals. PMID: 30301503
    2. EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4-positive T cells. PMID: 28067314
    3. IL-31 increased the concentration of intracellular Ca(2+) ions in mouse keratinocytes. PMID: 29477033
    4. IL-31 elicits itch not only through direct action on primary sensory neurones, but also by inducing LTB4 production in keratinocytes. PMID: 28512667
    5. IL31 and its receptor, IL31RA, are highly expressed in various human and mouse cancer cell lines, as well as in tumor specimens from cancer patients. MC38 murine colon carcinoma cells depleted of IL31 exhibit an increase in invasive and migratory properties in vitro. PMID: 28147314
    6. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. PMID: 26198770
    7. IL-31 upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA expression in mice PMID: 25381841
    8. our results suggest a functional cooperation between NFAT1 and JunB in mediating IL-31 gene expression in CD4(+) T cells PMID: 25595785
    9. Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions. PMID: 21182835
    10. IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases PMID: 15184896
    11. IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung. PMID: 17353366
    12. -31 antibody reduces scratching behaviour in an atopic dermatitis-like murine model during the onset of clinical skin manifestations PMID: 19054054
    13. these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine. PMID: 19414760

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲gv永久无码天堂网| 日本中文字幕人妻不卡dvd| 亚洲精品久久久久高潮| 开心色婷婷色五月激情| 国产精成人品日日拍夜夜| 在教室伦流澡到高潮h麻豆| 日本乱码伦午夜福利在线| 亚洲熟女乱色一区二区三区| 国产精品一线二线三线| 亚洲精品tv久久久久久久久久| 久久tv中文字幕首页| 免费人成在线视频无码| 少妇无码av无码专线区大牛影院| 被黑人猛躁10次高潮视频| 亚洲 中文字幕 日韩 无码| 熟妇丰满多毛的大隂户| 精品国产成人一区二区三区 | 国产精品青青在线麻豆| 人妻精品久久无码区| 真实国产熟睡乱子伦视频| 中国极品少妇xxxxx| 老司机亚洲精品影院无码| 色天天天综合色天天| 国产360激情盗摄全集| 国产成人欧美一区二区三区| 看免费真人视频网站| 波多野结衣绝顶大高潮| 波多野结衣乱码中文字幕| 久久综合给久久狠狠97色| 免费观看又污又黄的网站| 国产精品免费观看久久| 欧美一区二区三区视频在线观看| 粗壮挺进人妻水蜜桃成熟漫画| 蜜桃少妇av久久久久久久| 色婷婷香蕉在线一区二区| 国产精品美女一区二区视频 | 人人妻人人澡人人爽久久av| 国产精品刮毛| 国产乱人伦偷精品视频下| 8x国产精品视频| 成人免费视频一区二区三区|