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  4. Mouse Interleukin 16,IL-16 ELISA KIT

Mouse Interleukin 16,IL-16 ELISA KIT

  • 中文名稱：
    小鼠白介素16(IL-16)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04606m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠白介素16(IL-16)酶聯(lián)免疫試劑盒（CSB-E04606m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL16含量。IL16是一個重要靶點。它在免疫調(diào)節(jié)等生理過程中發(fā)揮關(guān)鍵作用。研究機制上，主要聚焦于其在細(xì)胞信號傳導(dǎo)通路中的作用，以及與炎癥、免疫相關(guān)疾病的關(guān)聯(lián)，解析其如何影響細(xì)胞功能和疾病發(fā)展進程，為相關(guān)藥物研發(fā)提供方向。試劑盒檢測范圍為7.8 pg/mL-500 pg/mL，適用于小鼠疾病模型構(gòu)建中的炎癥因子動態(tài)監(jiān)測、藥物干預(yù)效果評估以及免疫調(diào)控機制的基礎(chǔ)研究，為科研工作者研究IL - 16在免疫相關(guān)通路中的功能提供高效工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il16 ELISA Kit; Pro-interleukin-16 [Cleaved into: Interleukin-16 ELISA Kit; IL-16 ELISA Kit; Lymphocyte chemoattractant factor ELISA Kit; LCF)] ELISA Kit
  • 縮寫：
    IL16
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL-16 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %90
    Range %80-99
    1:2Average %96
    Range %91-101
    1:4Average %95
    Range %92-100
    1:8Average %98
    Range %86-115
  • 回收率：
    The recovery of mouse IL-16 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8880-115
    EDTA plasma (n=4)9590-108
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    5002.750 2.800 2.775 2.678
    2502.058 2.148 2.103 2.006
    1251.258 1.366 1.312 1.215
    62.50.785 0.840 0.813 0.716
    31.20.520 0.482 0.501 0.404
    15.60.385 0.383 0.384 0.287
    7.80.196 0.199 0.198 0.101
    00.098 0.096 0.097 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • 基因功能參考文獻：
    1. The production of IL-16 contributed to lung damage as neutralization of IL-16 enhanced S. aureus clearance and resulted in diminished lung pathology in S. aureus pneumonia. PMID: 24736233
    2. Data indicate that knockdown of translocator protein TSPO by siRNAhad showed no effect on the productions of TNF-alpha, IL-1beta and IL-6 in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells. PMID: 25200148
    3. Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. PMID: 23894370
    4. Data show overexpression of pro-IL-16 impaired resting B cell proliferation mediated through regulating nuclear factor (NF)-kappaB activation, and siRNA knock-down of pro-IL-16 expression decreased the level of p27(kip) and increased the level of Skp2. PMID: 23297678
    5. We determined that ovalbumin (OVA)-sensitized mice have an increase in systemic tumor necrosis factor-alpha levels, and that serum or BAL fluid stimulation of bronchial epithelial cells results in production of IL-16 PMID: 12594062
    6. IL-16 induces a greater migratory response in the Th1 cell subset than in the Th2 subset. PMID: 14607889
    7. interleukin-16 and its precursor have roles in T lymphocyte activation and growth [review] PMID: 15253385
    8. IL-16 precursor mRNA and protein expression are dynamically regulated during CD4+ T cell activation by a calcineurin-dependent mechanism; pro-IL-16 may influence T cell cycle regulation, although not in a dominant manner. PMID: 15728482
    9. Caspase-3 mediated production of IL-16 by infiltrating CD4+ T cells, contributes to ongoing neuroinflammation by chemoattraction of additional waves of CD4+ T cells. PMID: 16271292
    10. After femoral artery ligation, CD8+ T cells infiltrate the site of collateral vessel growth and recruit CD4+ mononuclear cells through the expression of IL-16 PMID: 16380545
    11. Inactivation of IL-16 by antibody therapy or IL-16 deficiency prevented ischemia-reperfusion injury of the kidney, as shown by reduced levels of serum creatinine or blood urea nitrogen. PMID: 18004294
    12. Generation of bleomycin-induced lung fibrosis is independent of IL-16 PMID: 19232499
    13. CD4-positive T cells are specifically recruited to the lung in a dendritic cell-independent but IL-16-dependent process and diminish neutrophil recruitment through increased IL-10 production. PMID: 19641139

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  • 亞細(xì)胞定位：
    Secreted.; [Isoform 1]: Cytoplasm. Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites.; [Isoform 2]: Cytoplasm. Nucleus.
  • 組織特異性：
    Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.
  • 數(shù)據(jù)庫鏈接：


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