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  4. Mouse Insulin-like growth factor binding protein 2,IGFBP-2 ELISA KIT

Mouse Insulin-like growth factor binding protein 2,IGFBP-2 ELISA KIT

  • 中文名稱：
    小鼠胰島素樣生長因子結合蛋白2(IGFBP-2)酶聯免疫試劑盒
  • 貨號：
    CSB-E04589m
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠胰島素樣生長因子結合蛋白2(IGFBP-2)酶聯免疫試劑盒（CSB-E04589m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IGFBP2含量。IGFBP2即胰島素樣生長因子結合蛋白2，在多種腫瘤組織中高表達，可調節細胞增殖、存活與遷移等。其研究機制主要聚焦于影響腫瘤微環境、參與信號通路傳導，和腫瘤的發生、發展及轉移密切相關，是腫瘤治療潛在的重要靶點。試劑盒檢測范圍為0.45 ng/mL-30 ng/mL，適用于科研領域對小鼠IGFBP - 2蛋白水平的精準分析，如代謝性疾病模型研究、癌癥發生機制探索或生長發育相關實驗中的蛋白表達動態監測。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Igfbp2 ELISA Kit; Igfbp-2Insulin-like growth factor-binding protein 2 ELISA Kit; IBP-2 ELISA Kit; IGF-binding protein 2 ELISA Kit; IGFBP-2 ELISA Kit; mIGFBP-2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.45 ng/mL-30 ng/mL
  • 靈敏度：
    0.11 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IGFBP-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:20 Average % 103    
    Range % 98-107    
    1:40 Average % 84    
    Range % 80-88    
    1:80 Average % 96    
    Range % 92-100    
    1:160 Average % 90    
    Range % 86-94    
  • 回收率：
    The recovery of mouse IGFBP-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 88 84-92    
    EDTA plasma (n=4) 95 90-100    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    30 2.641 2.496 2.569 2.470    
    15 1.750 1.625 1.688 1.589    
    7.5 1.004 1.080 1.042 0.943    
    3.75 0.638 0.659 0.649 0.550    
    1.8 0.329 0.313 0.321 0.222    
    0.9 0.215 0.204 0.210 0.111    
    0.45 0.162 0.171 0.167 0.068    
    0 0.096 0.102 0.099 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻：
    1. AAV6-mediated IGFBP-2 overexpression in the tibialis anterior (TA) muscles of 4-week-old C57BL/10 and mdx mice reduced the mass of injected muscle after 8weeks, inducing a slower muscle phenotype in C57BL/10 but not mdx mice. Analysis of inflammatory and fibrotic gene expression revealed no changes between control and IGFBP-2 injected muscles in dystrophic (mdx) mice. PMID: 27544574
    2. Peptides that disrupted p62/PKCzeta or p62/IRS-1 inhibited IGF-I/IGFBP-2 stimulated PKCzeta activation, vimentin phosphorylation, PTEN tyrosine phosphorylation, AKT activation, and osteoblast differentiation. PMID: 26773517
    3. In human whole blood cells, methylation of IGFBP2 at the homologous CpG site was increased in obese men with impaired glucose tolerance. In conclusion, our data show that increased methylation of hepatic Igfbp2 during infancy predicts the development of fatty liver later in life and is linked to deterioration of glucose metabolism. PMID: 27126637
    4. IGFBP2 not only is a driver of glioma progression and a prognostic factor but is also required for tumour maintenance and thus represents a viable therapeutic target in the treatment of glioma. PMID: 27125842
    5. that the lacking the Arg-Gly-Asp-domain has a major influence on the pleiotropic effects of IGFBP-2 and suggest that somatic growth and time of sexual maturity or somatic growth and life expectancy are less closely related than thought previously PMID: 26507795
    6. Data (including data from studies in knockout mice) suggest, as osteoblasts differentiate, early induction of AMPK in response to IGF-I/IGFBP-2 is followed by suppression of AMPK as required for osteogenesis; activation of AMPK stimulates autophagy. PMID: 26556533
    7. estrogen deficiency has a profound effect on body and bone composition in the absence of IGFBP-2 and may be related to changes in fibroblast growth factor 21. PMID: 26230658
    8. Impaired glucose clearance in female IGFBP-2 transgenic mice is dependent on the presence of the RGD motif and that translocation of GLUT4 in the muscle may be regulated by IGFBP-2 via RGD-dependent mechanisms. PMID: 26105006
    9. protein(s) that associated with RPTPbeta in response to IGF-I and IGFBP-2 in vascular smooth muscle cells PMID: 25787077
    10. The results suggest that stimulation of differentiation is an important mechanism by which IGFBP-2 regulates the acquisition of normal bone mass in mice. PMID: 24839202
    11. PPARalpha controls IGF-1 signalling through the up-regulation of hepatic Igfbp-2 transcription during fasting. PMID: 25695641
    12. IGFBP2 is a critical cell-autonomous factor that promotes the survival and migration of acute leukemia cells. PMID: 24191913
    13. IGFBP-2 plays an IGF-I-dependent and -independent role in the brain's acute (neuroprotection) and chronic (tissue remodeling) response to hypoxic-ischemic injury. PMID: 24359611
    14. physiological levels of IGFBP2 are neither sufficient to mimic nor required for the physiological action of leptin PMID: 24424049
    15. Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development. PMID: 23813480
    16. These findings demonstrate that the HBD2 domain of IGFBP-2 is the primary region that accounts for its ability to inhibit adipogenesis and that a peptide encompassing this region has activity that is comparable with native IGFBP-2. PMID: 23981772
    17. we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 as candidate modifier genes of lung tumorigenesis. PMID: 22973541
    18. IGFBP-2 bound receptor protein tyrosine phosphatase beta, which led to its dimerization and inactivation. Analysis of aortas obtained from IGFBP-2(-/-) mice showed that receptor protein tyrosine phosphatase beta was activated. PMID: 22869525
    19. findings suggest that insulin upregulates IGFBP-2 expression through a PI3K/mTOR/C/EBP-alpha pathway in white adipocytes PMID: 22410287
    20. Data from transgenic mice suggest that hepatic leptin signaling (i.e., direct action of leptin on hepatocytes) is not required for leptin up-regulation of plasma levels of IGFBP-2; intact vagus nerve is also not required. PMID: 22202803
    21. IGFBP-2 is an important regulator of osteoclastogenesis. PMID: 22006816
    22. IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells. PMID: 21821709
    23. the HBD peptide of IGFBP-2 has anabolic activity by activating IGF-I/Akt and beta-catenin signaling pathways PMID: 21372140
    24. The present study was aimed at determining IGFBP2 mRNA levels in adipose tissue in conditions of insulin resistance such as aging and obesity. PMID: 20730703
    25. We propose that Igfbp2 mediates epidermal progenitor cell expansion and therefore represents an epidermal progenitor cell-specific target of Hedgehog signaling that promotes basal cell carcinoma development PMID: 20858761
    26. IGFBP-2 significantly inhibits postnatal skeletal myofiber growth by decreasing myogenic proliferation and protein accretion and enhances glycolytic muscle metabolism PMID: 20501873
    27. Overexpression of IGFBP2 by an adenovirus reversed diabetes in insulin-resistant and diet-induced obese mice, as well as insulin-deficient streptozotocin-treated mice. PMID: 20074524
    28. Data show that IGFBP-2 potently separates hypertrophic and hyperplastic effects of GH/IGF-I excess on adrenocortical cells. PMID: 12409314
    29. During cell differentiation, secretion is controlled by hormones in mouse mammary epithelial cells. PMID: 12914536
    30. effect of IGFBP-2 overexpression on the activity of various antioxidative enzymes in two malignant cell lines PMID: 14710363
    31. menin regulates the expression of the endogenous IGFBP-2 gene at least in part through the promoter of IGFBP-2. PMID: 15044367
    32. intact insulin-like growth factor binding protein-2 and a distinct carboxyl-terminal IGFBP-2 fragment localize to the cell nucleus PMID: 15474485
    33. IGFBP2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis PMID: 16556765
    34. IGFBP-2 may regulate bone turnover in both an IGF-I-dependent and -independent manner. PMID: 18276763
    35. IGF axis as key mechanisms underlying nephropathic responses of mesangial cells to Ang II and high glucose. PMID: 18392786
    36. Results suggest that the growth-promoting role of IGFBP-2 in prostate cancer is inhibited by its intracellular interaction with PAPA-1. PMID: 19095771
    37. IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis PMID: 19142966

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.
  • 數據庫鏈接：


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