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  4. Mouse Glia-derived nexin(SERPINE2) ELISA kit

Mouse Glia-derived nexin(SERPINE2) ELISA kit

  • 中文名稱：
    小鼠膠質(zhì)細(xì)胞源性連接蛋白(SERPINE2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL021082MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠膠質(zhì)細(xì)胞源性連接蛋白(SERPINE2)酶聯(lián)免疫試劑盒（CSB-EL021082MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SERPINE2含量。SERPINE2是重要靶點。它在細(xì)胞生長、遷移、黏附及組織重塑等生理過程有作用。研究機(jī)制方面，涉及調(diào)節(jié)蛋白酶活性等，其異常表達(dá)與腫瘤、神經(jīng)系統(tǒng)疾病等病理狀況相關(guān)，深入研究能為相關(guān)疾病治療提供新方向。試劑盒檢測范圍為3.12 pg/mL-200 pg/mL，該產(chǎn)品可廣泛應(yīng)用于神經(jīng)退行性疾病模型（如阿爾茨海默病）、中樞神經(jīng)損傷修復(fù)機(jī)制、膠質(zhì)瘤微環(huán)境研究等科研領(lǐng)域，特別適用于探究腦卒中、脊髓損傷等病理過程中膠質(zhì)細(xì)胞功能動態(tài)變化，以及腫瘤微血管生成相關(guān)分子機(jī)制分析。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Serpine2 ELISA Kit; Pi7 ELISA Kit; Pn1 ELISA Kit; Spi4Glia-derived nexin ELISA Kit; GDN ELISA Kit; Peptidase inhibitor 7 ELISA Kit; PI-7 ELISA Kit; Protease nexin 1 ELISA Kit; PN-1 ELISA Kit; Protease nexin I ELISA Kit; Serine protease-inhibitor 4 ELISA Kit; Serpin E2 ELISA Kit
  • 縮寫：
    SERPINE2
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    3.12 pg/mL-200 pg/mL
  • 靈敏度：
    0.78 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse SERPINE2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:100 Average % 103
    Range % 99-112
    1:200 Average % 84
    Range % 80-88
    1:400 Average % 97
    Range % 92-101
    1:800 Average % 90
    Range % 85-94
  • 回收率：
    The recovery of mouse SERPINE2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 89 85-93
    EDTA plasma (n=4) 95 90-100
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    200 2.185 2.312 2.249 2.111
    100 1.841 1.937 1.889 1.751
    50 1.437 1.385 1.411 1.273
    25 0.946 1.002 0.974 0.836
    12.5 0.598 0.579 0.589 0.451
    6.25 0.362 0.374 0.368 0.230
    3.12 0.235 0.226 0.231 0.093
    0 0.134 0.141 0.138 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
  • 基因功能參考文獻(xiàn)：
    1. SerpinE2 is required in the extracellular milieu of breast tumors where it acts in multiple ways to regulate tumor matrix deposition, thereby controlling tumor cell dissemination. PMID: 27793045
    2. These data uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accumulation. PMID: 27059719
    3. the involvement of PAI-1 in HIF-1-enhanced thrombosis and that an additional factor participates in regulating Pai-1 expression in compressed skin. PMID: 25939592
    4. aberrant Serpine2/Pn-1 is required for proliferation of human and mouse medulloblastoma cells. PMID: 25901736
    5. PN-1 strongly limits physiological angiogenesis. PMID: 26109427
    6. The PAI-1 inhibitor not only accelerated the expansion of the donor HSCs during the early-stage of regeneration, but also supported long-term hematopoiesis. PMID: 24155177
    7. a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity PMID: 25138159
    8. SERPINE2 and PLAU are involved in cumulus expansion and oocyte maturation. PMID: 24023701
    9. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID: 23661674
    10. PN-1 has direct antiangiogenic properties and is a yet-unrecognized player in the angiogenic balance PMID: 22331468
    11. SERPINE2 protein may play a role as a sperm decapacitation factor. PMID: 21084713
    12. platelet PN-1 can be considered as a new important regulator of thrombolysis in vivo PMID: 21403095
    13. SERPINE2 is a major plasminogen activator(PA) inhibitor in the placenta and uterus during the estrous cycle, pregnancy, and lactation. It may participate in the PA-modulated tissue remodeling process in the mouse placenta and uterus. PMID: 20977773
    14. Data suggest that lack of extinction in protease nexin-1 KO mice is associated with changes in neuronal activity in the circuitry of the basal and central amygdaloid nuclei, supporting a differential impact on fear extinction in these areas. PMID: 20529116
    15. Platelet PN-1 is a key player in the thrombotic process, whose negative regulatory role has been, up to now, markedly underestimated. PMID: 19855083
    16. PN-1 may have a role in regulating activities of muscle proteases PMID: 14733957
    17. We report that brain proteolytic activity was strongly regulated by neuronal activity, with PN-1 being a major controlling element. PMID: 15509762
    18. p65 binds to the kappaB-like DNA sequence located at approximately -9 kbp in the SerpinE2 PMID: 16697375
    19. Expression array analysis in murine models demonstrated association and repication of SERPINE2 as a potential COPD susceptibility gene. PMID: 16921128
    20. Results indicate that PN-1 could have a natriuretic role by inhibiting prostasin activity. Aldosterone and TGF-beta reciprocally regulate the expression of PN-1. PN-1 could represent a new factor that contributes to regulation of ENaC activity. PMID: 16941024
    21. Schwann cell-derived protease nexin-1 is crucial for proper reinervation and cell survival. PMID: 17409231
    22. PN-1 is upregulated in cryoglobulinemic membranoproliferative glomerulonephritis PMID: 18199802
    23. Results suggest that PN-1 might become a prognostic marker in breast cancer. PMID: 19584287

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  • 亞細(xì)胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Most abundant in seminal vesicles.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:20720

    STRING: 10090.ENSMUSP00000027467

    UniGene: Mm.3093



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