在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Mouse GDNF family receptor alpha-like(GFRAL) ELISA kit

Mouse GDNF family receptor alpha-like(GFRAL) ELISA kit

  • 中文名稱：
    小鼠GDNF家族α樣受體(GFRAL)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL009383MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠GDNF家族α樣受體(GFRAL)酶聯(lián)免疫試劑盒（CSB-EL009383MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的GFRAL含量。GFRAL是一個重要靶點(diǎn)。它與機(jī)體能量代謝等生理過程密切相關(guān)。研究機(jī)制上，其能參與特定信號通路，可能成為調(diào)節(jié)能量平衡的關(guān)鍵環(huán)節(jié)。目前圍繞它正開展眾多科研工作，有望為肥胖癥等代謝疾病治療帶來新策略。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，本試劑盒通過高特異性配對抗體實(shí)現(xiàn)目標(biāo)蛋白的精準(zhǔn)捕獲與信號放大，適用于基礎(chǔ)科研領(lǐng)域探索GFRAL在代謝性疾病動物模型中的動態(tài)變化、評估特定組織或細(xì)胞中受體表達(dá)差異，以及篩選調(diào)控GFRAL通路的藥物或生物活性分子。產(chǎn)品嚴(yán)格驗(yàn)證了線性范圍與靈敏度指標(biāo)，可滿足體外實(shí)驗(yàn)中低豐度蛋白的穩(wěn)定檢測需求，為代謝機(jī)制研究、神經(jīng)內(nèi)分泌調(diào)控及疾病模型構(gòu)建提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Gfral ELISA Kit; Gral ELISA Kit; GDNF family receptor alpha-like ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse GFRAL in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 92
    Range % 88-98
    1:2 Average % 101
    Range % 97-107
    1:4 Average % 94
    Range % 90-98
    1:8 Average % 97
    Range % 92-101
  • 回收率：
    The recovery of mouse GFRAL spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 89-100
    EDTA plasma (n=4) 88 84-92
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1600 1.859 1.952 1.906 1.766
    800 1.258 1.260 1.259 1.119
    400 0.720 0.734 0.727 0.587
    200 0.466 0.489 0.478 0.338
    100 0.315 0.328 0.322 0.182
    50 0.229 0.235 0.232 0.092
    25 0.172 0.176 0.174 0.034
    0 0.138 0.141 0.140 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. isolating GFRAL as the receptor for GDF15-induced anorexia and weight loss, the identification of a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress; findings provide opportunities to develop therapeutic agents for the treatment of disorders with altered energy demand PMID: 28953886
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein; Extracellular side.
  • 蛋白家族：
    GDNFR family
  • 組織特異性：
    Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:404194

    UniGene: Mm.213862



主站蜘蛛池模板： 中文幕无线码中文字夫妻| 裸身美女无遮挡永久免费视频| 精品国产偷窥一区二区| 日韩成人无码| 亚洲人禽杂交av片久久| 亚洲国产成人无码电影| 亚洲熟女www一区二区三区| 国产午夜亚洲精品不卡下载| 国产精品免费无遮挡无码永久视频| 欧美片内射欧美美美妇| 天天躁夜夜躁狠狠综合2020| 精品熟女少妇av免费久久| 美女啪啪网站又黄又免费| 丰满日韩放荡少妇无码视频| 中文字幕日本乱码仑区在线| 狂野欧美激情性xxxx| 中文幕无线码中文字蜜桃| 99视频有精品视频高清| 免费观看日本污污ww网站| 绝顶丰满少妇av无码| 忘忧草社区中文字幕www| 国产精品爽爽ⅴa在线观看| 日本高清色倩视频在线观看| 综合色区亚洲熟妇另类| 人人妻人人爽人人做夜欢视频九色| 久久好在线视频| 国产精品婷婷久久爽一下| 精品国产综合成人亚洲区| 成在人线av无码免费看网站| 国产欧美va欧美va香蕉在线| 国产精品女同一区二区| 久久www成人免费网站| 欧美视频专区一二在线观看| 非洲黑人最猛性xxxx交| 国产精品人成视频国模| 玩弄丰满少妇人妻视频| 久久人人玩人妻潮喷内射人人| 天天做天天躁天天躁| 精品国产v无码大片在线观看| 熟妇高潮喷沈阳45熟妇高潮喷| 青青爽无码视频在线观看|