Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.; Cytoplasmic form induces gene transcription inhibition.

1. Autosomal Dominant Polycystic Kidney Disease patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF-beta1 than controls PMID: 29794429
2. The results revealed that miR181a exerted a negative regulatory effect on BMMSCinduced CD4+T lymphocyte apoptosis by regulating FasL protein expression in BMMSCs; this maybe a key mechanism underlying the development of estrogen deficiencyinduced osteoporosis. PMID: 29845202
3. platelet-derived FasL has a role in apoptosis in stroke PMID: 27608763
4. the analysis of mRNA level showed that disease progression is associated with significantly increased expression of FasR and/or FasL. In conclusion, our observation seems to confirm that spherical model of cancer lines is more reliable for some sophisticated analysis because of their greater resemblance to the CSCs from human CRC samples in comparison to commonly used adherent cells PMID: 28766682
5. study indicates FAS-FASL promoter SNPs may promote the production of cross-reactive anti-ganglioside antibodies in GBS PMID: 29432441
6. Report dysregulation of the Fas/FasL system occurs in an experimental animal model of HELLP syndrome. PMID: 28501275
7. Vitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in diabetic cardiomyopathy rats, which might be used as a potential effective therapy for the disease. PMID: 28595623
8. Our data suggest that serum sFasL may serve as an indicator of apoptotic thyroid state. sFasL may also act as a useful predictor of a clinical course in GD. PMID: 28276714
9. This study highlights a coordinated neurovascular development instructed by CNS macrophage-derived CD95L. PMID: 28514658
10. this study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular acute rejection following pediatric renal transplantation PMID: 27109035
11. CD3(+) CD8(+) NKG2D(+) T Lymphocytes Induce Apoptosis and Necroptosis in HLA-Negative Cells via FasL-Fas Interaction PMID: 28294381
12. this study shows that the -844T/C polymorphism in the FasL gene confers risk to hepatocellular carcinoma in Egyptian patients PMID: 26891954
13. It has been shown that treatment with anti-FasL prevents lymphocyte apoptosis, upregulates type-1 responses to Trypanosoma cruzi antigens, and reduces infection in macrophages cocultured with activated CD8 T cells. PMID: 27195678
14. Here the authors show using an autoperfused flow chamber assay of whole blood neutrophils and intravital microscopy of the inflamed cremaster muscle that CD95 mediates leukocyte slow rolling, adhesion and transmigration upon binding of CD95-ligand (CD95L) that is presented by endothelial cells. PMID: 27763263
15. The interaction of Fas receptor with FasL leads to an activation of the Tag7-Hsp70 complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex PMID: 27868339
16. this study shows that one-time intraocular adeno-associated virus-mediated gene delivery of soluble FasL provides complete and sustained neuroprotection in the models of glaucoma PMID: 27849168
17. Study found that propofol anesthesia activates Fas/FasL-mediated extrinsic and Bcl-2-dependent intrinsic apoptotic pathways, resulting in caspase-8 and caspase-9 activations, respectively, and established upregulation of caspase-1 and IL-1beta cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood. PMID: 27189477
18. this study shows that neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells restricts autoantibody production by B cells during inflammasome-driven inflammation PMID: 27798616
19. Expression of FasL on the surface of peripheral B-1 cells increased in filarial patients and positively correlated with peripheral apoptotic T-helper cells indicating FasL-expressing B-1 cells may be one of the important mediators of Th-cell apoptosis and immune anergy during filarial pathology. PMID: 28208221
20. these data show for the first time LRH-1 expression in T cells, its role in FASLG transcription and the potential of pharmacological inhibition of LRH-1 in the treatment of FasL-mediated immunopathologies PMID: 28406481
21. CD95L has a proliferation-stimulating role during normal turnover of the small intestine, but has a marginal effect on overall intestinal homeostasis. PMID: 26700225
22. Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14. PMID: 27561622
23. FasL rs763110 C/T was associated with an increased risk of rheumatoid arthritis in Caucasian patients. PMID: 26905515
24. this study shows that FASL gene polymorphism and serum levels are associated with autoimmune thyroid diseases PMID: 27458112
25. The inhibition/facilitation of miR-98 expression in myocardial cells can modulate apoptosis. miR-98 was downregulated in the peripheral blood of myocarditis patients. It may interact with the FAS/FASL gene pair to further modulate cell apoptosis. PMID: 27323110
26. Our findings revealed a significant association of Fas -670 GG, FasL -844 TC, and CC genotypes with increased risk of Chronic myeloid leukemia PMID: 26563376
27. Different expression of FasL in placentas from Idiopathic intrauterine growth retardation (IUGR) and IUGR + Pre-eclampsia suggests that FasL probably has a different role in the etiology of these two syndromes. PMID: 25909501
28. Increased FasL expression is thought to be a basis for the immune evasion in non-small cell lung carcinomas. PMID: 26823709
29. The present study confirmed that both Fas/FasL signaling and SOCS1 promoted the high glucose induced mitochondrial dysfunction and apoptosis; results implies the key regulatory role of Fas signaling and SOCS in diabetic retinopathy PMID: 26700587
30. Meta-analysis: FASL -844 T/C polymorphism is associated with susceptibility to systemic lupus erythematosus. PMID: 27050822
31. Activation of TIM1 by exposing the cells to TIM4 significantly increased the frequency of apoptotic colon cancer cells. The expression of FasL was increased in the cancer cells after treating by TIM4. PMID: 26921445
32. FAS or FASL gene knockout might attenuate increase of caspase-3 caused by isoflurane. PMID: 26609525
33. In dermal fibroblasts THy1/beta3 integrin induced apoptosis is mediated by up-regulation of FaSL. PMID: 26967483
34. Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons. PMID: 26582200
35. We identified several genes (FasL, MSH2, ABCC5, CASP3, and CYP3A4)that showed association with PFS in patients with osteosarcoma. These pharmacogenetic risk factors might be useful to predict treatment outcome PMID: 25829401
36. data suggest that deficient regulation of Fas ligand expression by regulators such as the interleukin-12 signaling pathway may be an alternative cause of autoimmune lymphoproliferative syndrome-like disease. PMID: 26113417
37. There was no significant association between FasL SNPs and development of papillary thyroid cancer. PMID: 25824544
38. Data show that CD8+ T cells and Fas ligand (FasL) protect against infection with Plasmodium yoelii NL (PyNL). PMID: 25760084
39. Loss of c-REL but not NF-kappaB2 prevents autoimmune disease driven by FasL mutation. PMID: 25361085
40. genetic polymorphism is associated with rheumatoid arthritis, meta-analysis PMID: 25645050
41. Membrane-bound FasL mediates platelets-induced apoptosis, whereas Bax/Bak signaling is not required but reinforces platelets-induced apoptosis. PMID: 26232171
42. results showed that estrogen preserves FasL protein accumulation by inhibiting miR-181a expression in BMMSCs to maintain bone remodeling balance PMID: 26062603
43. we propose that CCs surrounding aging oocytes released sFasL in an apoptosis-related manner, and the released sFasL accelerated oocyte aging by binding to Fas receptors. PMID: 25731893
44. the FASL -844C>T polymorphism may reduce the risk of gynecological cancer. PMID: 25661359
45. The protective effect of the FASL CC genotype seen in this study suggests that similar biomolecular mechanisms involving FASL might play a role in female-specific cancers. PMID: 25472583
46. biliary tree stem/progenitor cells could modulate the T cell response through the production of FasL, which influences the lymphocyte Fas/FasL pathway by inducing "premature" apoptosis in CD4(+) and CD8(+) T cells PMID: 24953023
47. Systemic pharmacological inhibition of CD95L dampens the peripheral innate response, reduces the accumulation of infiltrating myeloid cells, and efficiently prevents MPTP-induced DN death. PMID: 25779632
48. The presence of the Fas gene polymorphism Fas A670G is associated with an increased risk of preeclampsia, while the presence of FasLG IVS2nt 124 A>G gene may be protective against preeclampsia. PMID: 24951049
49. Ectopic expression of Fas Ligand on cardiomyocytes renders cardiac allografts resistant to CD4(+) T-cell mediated rejection. PMID: 25497973
50. that deficiency in FasL reverse signaling may contribute to the clinical lymphoproliferative phenotype of ALPS. PMID: 25451160

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[Isoform FasL]: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen.; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted.; [FasL intracellular domain]: Nucleus.

Tumor necrosis factor family

Expressed in T-cells. Expressed in natural killer cells.

KEGG: mmu:14103

STRING: 10090.ENSMUSP00000000834

UniGene: Mm.3355