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  4. Mouse EGF-like repeat and discoidin I-like domain-containing protein 3(EDIL3) ELISA kit

Mouse EGF-like repeat and discoidin I-like domain-containing protein 3(EDIL3) ELISA kit

  • 中文名稱：
    小鼠EGF樣重復序列和盤狀結構域蛋白3(EDIL3)酶聯免疫試劑盒
  • 貨號：
    CSB-EL007399MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠EGF樣重復序列和盤狀結構域蛋白3(EDIL3)酶聯免疫試劑盒（CSB-EL007399MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的EDIL3含量。試劑盒檢測范圍為28 pg/mL-1800 pg/mL，研究人員可通過本產品探究EDIL3在腫瘤微環境調控、血管內皮細胞功能或再生醫學研究中的動態變化，例如評估疾病模型動物特定組織中EDIL3的表達模式，或體外培養細胞分泌EDIL3的調控機制，為相關分子機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Edil3 ELISA kit; Del1EGF-like repeat and discoidin I-like domain-containing protein 3 ELISA kit; Developmentally-regulated endothelial cell locus 1 protein ELISA kit; Integrin-binding protein DEL1 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    28 pg/mL-1800 pg/mL
  • 靈敏度：
    7 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse EDIL3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %87-94
    1:2Average %97
    Range %92-100
    1:4Average %90
    Range %88-95
    1:8Average %92
    Range %85-96
  • 回收率：
    The recovery of mouse EDIL3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9389-97
    EDTA plasma (n=4)9895-102
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    18002.812 2.998 2.905 2.743
    9002.215 2.345 2.280 2.118
    4501.803 1.804 1.804 1.642
    2251.210 1.261 1.236 1.074
    112.50.672 0.720 0.696 0.534
    560.406 0.431 0.419 0.257
    280.270 0.251 0.261 0.099
    00.157 0.166 0.162
  • 數據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 功能：
    Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
  • 基因功能參考文獻：
    1. these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation. PMID: 29684347
    2. these data reveal an unrecognised function of endogenous Del-1 as a local inhibitor of ischaemia-induced angiogenesis by restraining LFA-1-dependent homing of pro-angiogenic haematopoietic cells to ischaemic tissues PMID: 28447099
    3. Del-1-induced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on hematopoietic progenitors. PMID: 28846069
    4. Del-1 intercepted oxLDL before its receptor binding to reduce atherogenesis PMID: 27784857
    5. EDIL3-mediated activation of TGF-beta and ERK signaling could provide therapeutic implications for HCC. PMID: 25980764
    6. Study identified Del-1 as an endogenous homeostatic factor of the CNS protecting from neuroinflammation in the course of CNS autoimmunity PMID: 25385367
    7. Del-1 controls NF-kappaB-activated MIF production in macrophages. PMID: 24504014
    8. The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment. PMID: 24416060
    9. Bleomycin-induced pulmonary fibrosis increased collagen deposition and TGF-beta production in the lung of Del-1(-/-) mice. PMID: 24525119
    10. Decreased Del-1 expression is associated with salivary gland inflammation in Sjogren syndrome. PMID: 24060278
    11. Observed increased leukocyte accumulation, inflammation, and higher apoptosis in the adrenal glands of Del-1-deficient mice. Del-1 deficiency was also associated with reduced corticosterone and ACTH levels 24 hours after lipopolysaccharide administration. PMID: 23364949
    12. Del-1 suppressed LFA-1-dependent recruitment of neutrophils and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic agent for inflammatory diseases. PMID: 22447028
    13. Del-1 plays a physiological role in the clearance of phosphatidylserine-expressing microparticles by endothelium. PMID: 22388320
    14. The apoptosis-inducing activity of Del1 could be mapped to the third EGF motif, which fitted the consensus sequence CX(D/N)XXXX(F/Y)XCXC, wherein the aspartic acid residue (D) could be beta-hydroxylated. PMID: 20171188
    15. mediates vascular smooth muscle cells adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3) PMID: 11959660
    16. acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis PMID: 12074641
    17. Del-1 is expressed in ischemic tissue. Del-1 stimulates angiogenesis, an effect that is dependent on the RGD motif and a second signaling sequence in the discoidin-I-like domain. PMID: 14981004
    18. Demonstration of Del-1 and milk fat globule-EGF-factor 8 (MFG-E8) binding to phosphatidylserine exposed on apoptotic cells suggests the existence of macrophage subsets that use Del-1 or MFG-E8 differently to engulf apoptotic cells. PMID: 15004195
    19. Del1 (Edil3) is induced by a number of growth factors/cytokines including VEGF, indicating the possible involvement of Del1 in tumor angiogenesis. PMID: 15964546
    20. Fusion with the deposition domain of Del1 dramatically alters the distribution of exogenous proteins in mice. PMID: 17701220
    21. Constitutive expression of Del1 in skin does not affect skin vascularity or improve wound healing. PMID: 17764695
    22. Del-1 may participate in modulating cerebral angiogenesis, and that gene transfer of Del-1 may provide a novel and potent means for stimulating cerebral angiogenesis. PMID: 18534562
    23. study describes Del-1 as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion; Del-1 is an endogenous inhibitor of inflammatory cell recruitment PMID: 19008446

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Expressed in angioblasts and early endothelial cells. By embryonic day 13.5, also expressed in a restricted group of non-endothelial cells including chondrocytes and retinal neurons.
  • 數據庫鏈接：


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