在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Mouse Complement C1q subcomponent subunit A(C1QA) ELISA kit

  • 中文名稱:
    小鼠補體C1q亞基A(C1QA)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL003637MO
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠補體C1q亞基A(C1QA)酶聯(lián)免疫試劑盒(CSB-EL003637MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的C1QA含量。C1QA 是補體經(jīng)典途徑起始分子 C1 的亞基之一。它在免疫調(diào)節(jié)、清除凋亡細胞等過程有重要作用。研究發(fā)現(xiàn)其參與炎癥反應(yīng)、神經(jīng)退行性疾病等病理機制,還與腫瘤免疫逃逸相關(guān),對其深入研究有望為相關(guān)疾病治療提供新靶點。試劑盒檢測范圍為0.156 μg/mL-10 μg/mL,適用于探究小鼠模型中補體系統(tǒng)的激活機制、免疫相關(guān)疾病病理過程以及藥物干預(yù)對C1QA表達的影響等基礎(chǔ)研究,為免疫學(xué)、分子病理學(xué)等領(lǐng)域提供可靠的實驗工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    C1qaComplement C1q subcomponent subunit A ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.156 μg/mL-10 μg/mL
  • 靈敏度:
    0.039 μg/mL
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse C1QA in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)
    1:5 Average % 95
    Range % 90-110
    1:10 Average % 95
    Range % 89-99
    1:20 Average % 95
    Range % 87-101
    1:40 Average % 96
    Range % 85-105
  • 回收率:
    The recovery of mouse C1QA spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 88-99
    EDTA plasma (n=4) 93 86-99
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    μg/ml OD1 OD2 Average Corrected
    10 2.598 2.551 2.575 2.488
    5 1.452 1.484 1.468 1.381
    2.5 0.793 0.805 0.799 0.712
    1.25 0.434 0.422 0.428 0.341
    0.625 0.269 0.257 0.263 0.176
    0.312 0.176 0.182 0.179 0.092
    0.156 0.122 0.119 0.121 0.034
    0 0.089 0.085 0.087  
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能:
    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • 基因功能參考文獻:
    1. C1qa(-/-) mice did not show any differences in photoreceptor loss or inflammation at 7 days compared to wild-type PMID: 30126455
    2. The results presented here demonstrate that the C1q expression in aged females experience a distinct difference in brain aging when compared to age-matched males, suggesting females undergo a higher level of microglial activation with age. PMID: 28732515
    3. this study shows that regulatory dendritic cells can mediate a potent direct anti-inflammatory activity via the expression and/or secretion of molecules such as C1q, independently of their capacity to expand the pool of regulatory T cells PMID: 27731323
    4. Data preliminarily suggest that complement C1q activity may aid in the clearance of the Toxoplasma gondii parasite from the central nervous system and in so doing, have consequences for the connectivity of neighboring cells and synapses PMID: 27109609
    5. analysis of molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins modulated by complement protein C1q PMID: 27573737
    6. C1q-/- mice manifest increased frequency of fetal resorption, reduced fetal weight, and smaller litter size when compared to their wild-type counterparts PMID: 27687635
    7. This study demonstrated that microglia, but not neurons or peripheral sources, are the dominant source of C1q in the brain. PMID: 28264694
    8. findings show that C1q rather than FcgammaRs controls the Ab-mediated Ag uptake and its presentation by spleen APC subsets to T cells PMID: 28432146
    9. Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45-positive cells in kidney fibrosis. PMID: 28052876
    10. Deleting C1qa gene significantly reduces synaptic pruning by Grn(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn(-/-) mice; results uncover a previously unrecognized role of progranulin in suppressing aberrant microglia activation during aging. PMID: 27114033
    11. C1q level may be a surrogate of prediction marker representing neurodegenerative disease progress before developing behavioral impairment. PMID: 26728245
    12. developmental mechanisms of C1qa may be re-engaged during injury response PMID: 27008854
    13. that inhibition of C1 is sufficient to preserve dendritic and synaptic architecture PMID: 27048300
    14. These findings support a role for locally synthesized C1q in promoting tumor growth. PMID: 26831747
    15. C1q is involved in the pristane-mediated enhanced inflammatory response to TLR7 stimulation. PMID: 26773156
    16. C1q has a role in pulmonary vascular homeostasis and preventing injury to lung endothelium PMID: 26487714
    17. Data (including data from studies in mutant mice) suggest exercise prevents age-related neurovascular decline, up-regulation of C1qa, and down-regulation of astrocytic Apoe; this preventive effect of exercise does not occur in Apoe-deficient mice. PMID: 26512759
    18. critical role in activation of beta-catenin signalling in hypertensive arterial remodelling PMID: 25716000
    19. G allele in rs172378 risk factor for lupus nephritis in a homozygous status PMID: 25326229
    20. Data (including data on knockout mice) suggest, in absence of Trem2 (triggering receptor expressed on myeloid cells 2), pulmonary macrophages selectively produce elevated levels of C1q resulting in enhanced phagocytosis during pneumococcal pneumonia. PMID: 24945405
    21. Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins PMID: 25091012
    22. C1q was significantly reduced in newly diagnosed schizophrenic patients or schizophrenic patients on medication compared with the controls. PMID: 23235303
    23. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. PMID: 24170856
    24. The structural abnormalities, together with increased numbers of excitatory synapses, likely contribute to epileptogenesis in C1q KO mice. PMID: 23621154
    25. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity PMID: 23150673
    26. These findings suggest that C1q recognizes an alternative binding partner expressed by stressed retinal ganglion cells. PMID: 22918632
    27. Findings suggest the unexpected role of complement C1q in Wnt signal transduction and modulation of mammalian aging. PMID: 22682250
    28. Our data indicate that C1q could have a role in regulating platelet activation and associated leukocyte recruitment during vessel wall injury. PMID: 22142906
    29. Levels of C1q rise substantially in retinal tissues over the course of degeneration. in the absence of C1q, cone photoreceptor function and viability are significantly compromised. PMID: 21863053
    30. analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages PMID: 21862594
    31. Leukocyte recruitment and C1q-hemolytic activity was restored to wild type levels when CD93 was expressed on either hematopoietic cells or nonhematopoietic cells in bone marrow chimeric mice PMID: 21849679
    32. C1q, a marker of microglial activation, is upregulated in the nigrostriatal system following subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); nigrostriatal dopaminergic injury is not affected by C1q in this model of Parkinson disease. PMID: 21640391
    33. Mice with a mutation in complement component 1a (C1qa) were protected from glaucoma. PMID: 21383504
    34. Complement 1q (C1q)-deficient mice lacking the classical complement pathway show significantly reduced survival and increased organ dysfunction, following cecal ligation and puncture when compared with control mice. PMID: 21263075
    35. C1q directly promotes neuronal survival, thereby demonstrating new interactions between immune proteins and neuronal cells that may facilitate neuroprotection. PMID: 21368058
    36. Ethanol activates the classical complement pathway via C1q binding to apoptotic cells in the liver and that C1q contributes to the pathogenesis of ethanol-induced liver injury. PMID: 20416309
    37. Complement protein C1q forms a complex with cytotoxic prion protein oligomers PMID: 20410306
    38. These results suggest that C1q and C3 facilitate the induction of intranasal tolerance. PMID: 20213737
    39. Bacterial titers of both Streptococcus pneumoniae serotype 6A and 14 in the middle ear lavage fluid samples from Bf/C2(-/)(-), Bf(-)(/)(-), and C1qa(-/)(-) mice were significantly higher than in samples from wild-type mice. PMID: 20065024
    40. C1q contributes to apoptotic cell clearance in vitro, but its genetic deletion has no effect on pulmonary apoptotic cell clearance in vivo. PMID: 12244199
    41. Elevated expression of splenic prion protein (PrP) may be dependent on C1q, since PrP up-regulation does not occur in spleens of C1q-deficient mice following treatment with preformed immune complexes or vesicular stomatitis virus. PMID: 12794132
    42. Evaluation using C1q-deficient mice shows that lung injury following gastrointestinal ischemia-reperfusion injury is independent of C1q and classical complement activation. PMID: 15879138
    43. alpha2beta1 integrin is a novel receptor for multiple collectins and the C1q complement protein PMID: 16166590
    44. The transmembrane lectin SIGN-R1 therefore contributes to innate resistance by an unusual C3 activation pathway. PMID: 16615889
    45. bacterial titers in the CNS were almost 12- and 20-fold higher in C1q- and C3-deficient-mice, respectively. Mean CSF leukocyte counts were reduced by 47 and 73% in C1q- and C3-deficient-mice, respectively PMID: 17237437
    46. The in vitro binding and activation of the human and mouse complement systems was analysed and the susceptibility to infection in complement-deficient mouse strains, was tested. PMID: 18501966
    47. C1q participates in scrapie prion protein PrP(Sc) uptake by conventional dendritic cells (cDCs), revealing a critical role for cDCs in initial prion capture, an event that takes place before the PrP(Sc) accumulation within the follicular DC network. PMID: 19155476
    48. IgM antibodies play a central role in protection against atherosclerosis; the mechanism appears to be at least partly independent of classical pathway complement activation by C1q PMID: 19620499
    49. ARRB2 acts to limit JNK/ERK activation and survival in macrophages. PMID: 19783052

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产小受呻吟gv视频在线观看| 日韩高清成片免费视频| 在线观看国产精品va| 国产成人无码午夜视频在线观看| 日产中文字幕在线观看| 最新系列国产专区|亚洲国产| 国产美女露脸口爆吞精| 久久人妻少妇嫩草av | 日日噜噜噜夜夜爽爽狠狠视频| 精品玖玖玖视频在线观看| 男女猛烈无遮挡免费视频app | 丁香五月综合久久激情| 国产精品久久久久久影视不卡| 少妇被爽到高潮动态图| 久久精品人人槡人妻人| 日产乱码一二三区别免费麻豆| 久久久一本精品99久久精品88| 午夜无码一区二区三区在线观看| 亚洲影院天堂中文av色| 亚洲精品精华液一区二区| av永久天堂一区二区三区| 成人性生交大片免费看| 十八禁啪啪无遮挡网站| 男人边吃奶边揉好爽免费视频| 激情五月综合色婷婷一区二区| 亚洲国产精品不卡av在线| 日本亚州视频在线八a| 巨人精品福利官方导航| 欧美精品18videosex性欧美| 东京热无码一区二区三区av| 国产亚洲精品久久yy50| 97se亚洲国产综合在线| 亚洲综合色婷婷六月丁香宅男大增| 麻豆精品久久久久久中文字幕无码 | 中国美女毛茸茸撒尿| 人妻少妇偷人精品无码| 成人性欧美丨区二区三区| 天堂…中文在线最新版在线| 国产又色又爽又黄的| 亚洲精品偷拍无码不卡av| 极品少妇高潮到爽|