Mouse Cadherin-3(CDH3) ELISA kit
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中文名稱：小鼠鈣黏蛋白3(CDH3)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-EL005052MO
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規(guī)格：96T/48T
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價(jià)格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：小鼠鈣黏蛋白3(CDH3)酶聯(lián)免疫試劑盒（CSB-EL005052MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CDH3含量。CDH3是一種重要靶點(diǎn)。其背景在于在多種生理與病理過程中發(fā)揮關(guān)鍵作用，尤其在腫瘤發(fā)生發(fā)展里常異常表達(dá)。研究機(jī)制方面，主要聚焦于其在細(xì)胞黏附、信號(hào)傳導(dǎo)等過程的作用，探索通過干預(yù)它來抑制腫瘤生長(zhǎng)、轉(zhuǎn)移等的策略。試劑盒檢測(cè)范圍為78 pg/mL-5000 pg/mL，靈敏度為19.5 pg/mL。本試劑盒通過特異性抗體對(duì)實(shí)現(xiàn)高靈敏檢測(cè)，適用于小鼠模型中CDH3蛋白表達(dá)水平的動(dòng)態(tài)監(jiān)測(cè)，可廣泛用于腫瘤生物學(xué)、胚胎發(fā)育或炎癥微環(huán)境等領(lǐng)域的基礎(chǔ)研究?？蒲腥藛T可通過深入探究CDH3在細(xì)胞遷移調(diào)控、上皮間質(zhì)轉(zhuǎn)化等分子機(jī)制中的作用，為疾病相關(guān)信號(hào)通路研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：Cdh3; Cdhp; Cadherin-3; Placental cadherin; P-cadherin
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縮寫：
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測(cè)范圍：78 pg/mL-5000 pg/mL
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靈敏度：19.5 pg/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測(cè)波長(zhǎng)：450 nm
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研究領(lǐng)域：Neuroscience
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測(cè)定原理：quantitative
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測(cè)定方法：Sandwich
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數(shù)據(jù)處理：
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貨期：3-5 working days
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
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基因功能參考文獻(xiàn)：
- P-Cadherin is not required for maintenance of retinal stem cells in vivo. PMID: 28494434
- P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
- P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness. PMID: 22710718
- Loss of P-cadherin is associated with melanoma. PMID: 21445019
- UVB exposure resulted in the overexpression of the cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and the adhesion molecule P-cadherin. PMID: 20212509
- Truncated P-cadherin promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma. PMID: 16919267
- P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans whereas it is not required for either in mice. PMID: 18199584
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein.
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數(shù)據(jù)庫鏈接：
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