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Mouse CD70 antigen(CD70) ELISA kit

  • 中文名稱:
    小鼠CD70抗原(CD70)酶聯免疫試劑盒
  • 貨號:
    CSB-EL004954MO
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠CD70抗原(CD70)酶聯免疫試劑盒(CSB-EL004954MO)檢測樣本中的CD70含量。CD70是一種重要靶點。其背景在于它是腫瘤壞死因子超家族成員,在免疫細胞激活等方面有關鍵作用。研究機制方面,主要聚焦其與受體結合后的信號傳導通路,以及在腫瘤免疫逃逸機制中扮演的角色,為腫瘤免疫治療提供新思路。該產品適用于細胞裂解液、組織勻漿或體外培養上清等樣本類型,可廣泛用于探索免疫細胞功能、疾病模型機制及藥物干預研究中CD70的動態變化,為免疫學、腫瘤學等基礎研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Cd70; Cd27l; Cd27lg; Tnfsf7; CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
  • 基因功能參考文獻:
    1. CD70 mitigates atherosclerosis at least in part by modulating macrophage function. PMID: 27786334
    2. these findings demonstrate for the first time, to our knowledge, that T cell-derived CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses PMID: 29046346
    3. findings demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells. PMID: 28550198
    4. Mice lacking CD70 did not accumulate memory T cells and did not develop hypertension. PMID: 26988069
    5. find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization PMID: 26461455
    6. Data show that although CD70 is required for the activation of the antiviral adaptive response, it has a regulatory role in early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and function. PMID: 24913981
    7. the ability of CD70 to trigger costimulation is self-regulated when it binds its complementary receptor. PMID: 23913967
    8. Expression of CD70 by B cells aggravates experimental autoimmune encephalomyelitis by reducing the number of regulatory T cells. PMID: 23137837
    9. CD70-deficient mice infected with lymphocytic choriomeningitis virus produced only half as many T8 cells. Viral clearance was substantially delayed. CD70-mediated costimulation is not required for secondary or T4 responses. PMID: 23269247
    10. Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue PMID: 22798683
    11. CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load. PMID: 22450812
    12. Adoptively transferred CD70-specific T cells induced sustained regression of established murine xenografts. PMID: 21304103
    13. In this review, CD27 and CD70 constitute a unique ligand/receptor pair which can activate innate and adaptive immunity as well as regulate immunity versus tolerance. PMID: 20699361
    14. We show here that sterile chronic immune activation driven by enhanced expression of CD70 is in fact highly protective against atherosclerosis. PMID: 20505312
    15. Data show that costimulation by CD70 or OX40L seems to be necessary for primary CD4(+) T cell responses to multiple forms of immunization. PMID: 20639485
    16. These data support the hypothesis that induction of CD70 expression on dendritic cells (DC) after an encounter with activated CD4(+) T cells is a major component of CD4(+) T cell-mediated licensing of DC. PMID: 19952354
    17. Data indicate that, while CD70 plasma membrane expression is not detectable in resting T and B cells, low levels are induced following influenza infection in lung-infiltrating activated T cells and T and B cells in draining lymph nodes. PMID: 12496380
    18. Administration of antigenic peptide and a soluble recombinant form of CD70 results in a massive (>300-fold) expansion of antigen-specific CD8+ T cells in vivo, due to the enhanced proliferation and survival of activated T cells. PMID: 15128787
    19. CD70 expression on antigen presenting cells plays a key role in CD40-dependent CD8 T cell responses; CD70 blockade inhibits CD40-mediated clonal expansion of CD8 T cells and reduces the number of memory CD8 T cells generated. PMID: 15557144
    20. Expression of CD70 on dendritic cells is an important determinant for helper-dependence of primary CD8+ T cell expansion. PMID: 15634890
    21. The novel CD70-CD27 pathway plays a critical role in alloimmune responses independently of the CD28-B7 costimulatory pathway. PMID: 15661893
    22. CD70-positive antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. PMID: 15937486
    23. ectopic expression of CD70 in mouse glioma cells enhances apoptosis of T, B and NK cells in coculture, but nevertheless promotes glioma cell lysis by NK cells in vitro PMID: 16217761
    24. innate and adaptive (CD4+ T cells) arms of the immune system use a common signaling pathway in driving CD8+ T cell responses and suggest that expression of CD70 on dendritic cell (DC) represents the hallmark of conditioned DC PMID: 16920932
    25. CD70 expression on dendritic cells plays an important role in the priming of CD8-positive T cells by pathogens. PMID: 17295392
    26. CD70 is a decision maker for Th1 differentiation by CD205(+) dendritic cells. PMID: 17438065
    27. CD27-CD27L interactions are essential for developing a robust primary antiviral CD8-positive T cell immune response. PMID: 18292513
    28. injection of alpha-galactosylceramide triggers CD70 expression on splenic T cell zone dendritic cells and that this is dependent on CD40 signaling. PMID: 18354184
    29. the sole expression of CD70 by otherwise immature cDCs sufficed to convert CD8+ T cell tolerance into immunity, defining the importance of CD27-CD70 interactions at the interface between T cell and DC. PMID: 19062317
    30. The CD27-CD70 costimulatory pathway plays an important role in the development of experimental colitis; CD70 blockade leads directly to reduction in T cell numbers and thus reduces mucosal inflammation. PMID: 19525396
    31. CD27L requires trimer stabilization and oligomerization PMID: 19596991
    32. endogenous IL-18 might facilitate stomach cancer cell immune escape by suppressing CD70 and increasing metastatic ability by upregulating CD44 and VEGF PMID: 19638429

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  • 亞細胞定位:
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Tumor necrosis factor family
  • 組織特異性:
    Very low level of expression. Detected in splenocytes and thymocytes.
  • 數據庫鏈接:


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