在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse C-C motif chemokine 28(CCL28) ELISA kit

Mouse C-C motif chemokine 28(CCL28) ELISA kit

  • 中文名稱：
    小鼠C-C趨化因子28（CCL28）酶聯免疫試劑盒
  • 貨號：
    CSB-EL004792MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠C-C趨化因子28（CCL28）酶聯免疫試劑盒（CSB-EL004792MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL28含量。CCL28，又稱粘膜相關上皮趨化因子（MEC），是一種CC趨化因子，存在于幾乎所有粘膜組織中，具有免疫刺激作用。CCL28能與CCR3和CCR10結合，介導免疫反應、病毒感染、癌癥及抗菌作用。研究顯示，CCL28-CCR10通路在類風濕關節炎中促進單核細胞遷移，可能參與滑膜炎癥和骨破壞。試劑盒檢測范圍為78 pg/ml- 5000 pg/ml，靈敏度為19.5 pg/ml。可廣泛用于探究感染性疾病、自身免疫反應或黏膜屏障功能異常的小鼠模型中CCL28的動態變化，為黏膜免疫調控機制、炎癥通路分析及藥物干預效果評估提供可靠工具；尤其在腸道和呼吸道相關疾病機制研究中具有重要價值。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Ccl28 ELISA Kit; Scya28 ELISA Kit; C-C motif chemokine 28 ELISA Kit; Small-inducible cytokine A28 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/ml - 5000 pg/ml
  • 靈敏度：
    19.5 pg/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse CCL28 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    97

    Range %

    92-105

    1:2

    Average %

    92

    Range %

    88-95

    1:4

    Average %

    86

    Range %

    80-94

    1:8

    Average %

    89

    Range %

    84-98

  • 回收率：

    The recovery of mouse CCL28 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    92

    87-98

    EDTA plasma (n=4)

    102

    95-108

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    5000

    2.692

    2.921

    2.807

    2.681

    2500

    2.157

    2.166

    2.162

    2.036

    1250

    1.469

    1.522

    1.496

    1.370

    625

    0.866

    0.848

    0.857

    0.731

    312

    0.523

    0.545

    0.534

    0.408

    156

    0.324

    0.336

    0.330

    0.204

    78

    0.233

    0.252

    0.243

    0.117

    0

    0.129

    0.122

    0.126

    　

  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Chemotactic for resting CD4, CD8 T-cells and eosinophils. Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.
  • 基因功能參考文獻：
    1. Blockade of CCL28 or CCR10 during an acute severe respiratory paramyxoviral infection is sufficient to prevent the development of post-viral airway disease. However, the mechanism of action is unclear and requires further exploration. PMID: 28474501
    2. These data suggest that CCL28 could be useful in enhancing the IgA immune response that will likely play a pivotal role in prophylactic HIV vaccines. PMID: 22066023
    3. tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis PMID: 21753853
    4. demonstrate that interactions between the antimicrobial C-terminus of CCL28 with an appropriate CC chemokine N-terminal domain is important for the full antimicrobial activity of CCL28. PMID: 19830739
    5. CCL28 has dual functions in mucosal immunity as a chemokine attracting cells expressing CCR10 and/or CCR3 and also as an apically secreted molecule with a potent antimicrobial activity against a broad spectrum of microbes. PMID: 12538707
    6. MEC attracts IgA- but not IgG- or IgM-producing plasmablasts from both intestinal and nonintestinal lymphoid and effector tissues, including the intestines, lungs, and lymph nodes draining the bronchopulmonary tree and oral cavity. PMID: 12646646
    7. Epithelial cells and venular endothelium of both small intestine and colon are positive for CCL28; CCL28 plays a direct role in intestinal homing of IgA antibody-secreting cells by mediating their extravasation into intestinal lamina propria. PMID: 15356112
    8. CCL28 is a key regulator of IgA ASC accumulation in the mammary gland and thus controls the passive transfer of IgA antibodies from mother to infant. PMID: 15381732
    9. CCL28 appears to play a role in regulating eosinophil recruitment to peribronchial regions of the lung possibly by coordinated temporal production with eotaxin PMID: 15681819
    10. CCL28 mediates mucosal immunity in HIV exposure and infection PMID: 17912348

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲欧美色一区二区三区| 日韩人妻少妇一区二区| 国产精品久久久午夜夜伦鲁鲁| 日韩超碰人人爽人人做人人添| 硬了进去湿好大娇喘视频| 日产乱码一二三区别免费麻豆| 国产极品久久久久极品| 国内精品伊人久久久久影院麻豆| 色8久久人人97超碰香蕉987| 午夜无码一区二区三区在线| 7777久久久国产精品消防器材| 亚洲va久久久噜噜噜久久| 日本成熟老妇乱| 成 人 网 站94免费观看| 美女网站免费福利视频| 国产手机在线αⅴ片无码观看| 国产日韩欧美亚洲精品中字| 色欲天天天天天综合网| 日本三级香港三级三级人!妇久| 最近中文字幕mv在线资源| 亚洲综合色噜噜狠狠网站超清| 2021麻豆剧传媒一二三区| 97人妻天天摸天天爽天天| 无码无遮挡又大又爽又黄的视频| 亚洲国产精品无码久久久动漫| 日本嫩交12一16xxx视频| 狠狠色综合激情丁香五月| 亚洲a片国产av一区无码| 精品久久久久久亚洲中文字幕| 欧美一区二区三区红桃小说| 久久伊人色av天堂九九| 久久亚洲精品成人av二次元| 717影院理论午夜伦八戒| 精品人妻av区| 男女同房做爰爽免费| 制服丝袜亚洲中文欧美在线| 农村欧美丰满熟妇xxxx| 无码人妻精品一区二区三| 色婷婷五月综合欧美图片| 精品无码av无码免费专区| 欧美v国产v亚洲v日韩九九|