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  4. Mouse C-C motif chemokine 28(CCL28) ELISA kit

Mouse C-C motif chemokine 28(CCL28) ELISA kit

  • 中文名稱：
    小鼠C-C趨化因子28（CCL28）酶聯免疫試劑盒
  • 貨號：
    CSB-EL004792MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠C-C趨化因子28（CCL28）酶聯免疫試劑盒（CSB-EL004792MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL28含量。CCL28，又稱粘膜相關上皮趨化因子（MEC），是一種CC趨化因子，存在于幾乎所有粘膜組織中，具有免疫刺激作用。CCL28能與CCR3和CCR10結合，介導免疫反應、病毒感染、癌癥及抗菌作用。研究顯示，CCL28-CCR10通路在類風濕關節炎中促進單核細胞遷移，可能參與滑膜炎癥和骨破壞。試劑盒檢測范圍為78 pg/ml- 5000 pg/ml，靈敏度為19.5 pg/ml。可廣泛用于探究感染性疾病、自身免疫反應或黏膜屏障功能異常的小鼠模型中CCL28的動態變化，為黏膜免疫調控機制、炎癥通路分析及藥物干預效果評估提供可靠工具；尤其在腸道和呼吸道相關疾病機制研究中具有重要價值。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Ccl28 ELISA Kit; Scya28 ELISA Kit; C-C motif chemokine 28 ELISA Kit; Small-inducible cytokine A28 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/ml - 5000 pg/ml
  • 靈敏度：
    19.5 pg/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse CCL28 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    97

    Range %

    92-105

    1:2

    Average %

    92

    Range %

    88-95

    1:4

    Average %

    86

    Range %

    80-94

    1:8

    Average %

    89

    Range %

    84-98

  • 回收率：

    The recovery of mouse CCL28 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    92

    87-98

    EDTA plasma (n=4)

    102

    95-108

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    5000

    2.692

    2.921

    2.807

    2.681

    2500

    2.157

    2.166

    2.162

    2.036

    1250

    1.469

    1.522

    1.496

    1.370

    625

    0.866

    0.848

    0.857

    0.731

    312

    0.523

    0.545

    0.534

    0.408

    156

    0.324

    0.336

    0.330

    0.204

    78

    0.233

    0.252

    0.243

    0.117

    0

    0.129

    0.122

    0.126

    　

  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Chemotactic for resting CD4, CD8 T-cells and eosinophils. Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.
  • 基因功能參考文獻：
    1. Blockade of CCL28 or CCR10 during an acute severe respiratory paramyxoviral infection is sufficient to prevent the development of post-viral airway disease. However, the mechanism of action is unclear and requires further exploration. PMID: 28474501
    2. These data suggest that CCL28 could be useful in enhancing the IgA immune response that will likely play a pivotal role in prophylactic HIV vaccines. PMID: 22066023
    3. tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis PMID: 21753853
    4. demonstrate that interactions between the antimicrobial C-terminus of CCL28 with an appropriate CC chemokine N-terminal domain is important for the full antimicrobial activity of CCL28. PMID: 19830739
    5. CCL28 has dual functions in mucosal immunity as a chemokine attracting cells expressing CCR10 and/or CCR3 and also as an apically secreted molecule with a potent antimicrobial activity against a broad spectrum of microbes. PMID: 12538707
    6. MEC attracts IgA- but not IgG- or IgM-producing plasmablasts from both intestinal and nonintestinal lymphoid and effector tissues, including the intestines, lungs, and lymph nodes draining the bronchopulmonary tree and oral cavity. PMID: 12646646
    7. Epithelial cells and venular endothelium of both small intestine and colon are positive for CCL28; CCL28 plays a direct role in intestinal homing of IgA antibody-secreting cells by mediating their extravasation into intestinal lamina propria. PMID: 15356112
    8. CCL28 is a key regulator of IgA ASC accumulation in the mammary gland and thus controls the passive transfer of IgA antibodies from mother to infant. PMID: 15381732
    9. CCL28 appears to play a role in regulating eosinophil recruitment to peribronchial regions of the lung possibly by coordinated temporal production with eotaxin PMID: 15681819
    10. CCL28 mediates mucosal immunity in HIV exposure and infection PMID: 17912348

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung.
  • 數據庫鏈接：


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