在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Mouse BMP-binding endothelial regulator protein(BMPER) ELISA kit

  • 中文名稱:
    小鼠BMP結(jié)合內(nèi)皮調(diào)節(jié)因子(BMPER)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL002747MO
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠BMP結(jié)合內(nèi)皮調(diào)節(jié)因子(BMPER)酶聯(lián)免疫試劑盒(CSB-EL002747MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的BMPER含量。BMPER是一個靶點。其它在相關(guān)生理過程中可能發(fā)揮一定作用。研究機制上,或許參與調(diào)控骨形態(tài)發(fā)生蛋白信號通路等,影響細(xì)胞的生長、分化等過程,但目前關(guān)于它的詳細(xì)研究機制還需進一步深入探索以明確其具體作用。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL,廣泛應(yīng)用于基礎(chǔ)科研領(lǐng)域,例如通過檢測疾病模型動物(如血管異常或器官發(fā)育缺陷模型)中BMPER的表達(dá)動態(tài),探索其在病理生理中的作用機制,或用于體外細(xì)胞實驗中蛋白表達(dá)水平的定量評估,為信號通路研究、藥物靶點篩選及分子互作分析提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Bmper ELISA kit; Cv2BMP-binding endothelial regulator protein ELISA kit; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator ELISA kit; Protein crossveinless-2 ELISA kit; mCV2 ELISA kit
  • 縮寫:
    BMPER
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍:
    31.25 pg/mL-2000 pg/mL
  • 靈敏度:
    7.81 pg/mL
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能:
    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
  • 基因功能參考文獻:
    1. BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment. PMID: 29093060
    2. CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
    3. BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. PMID: 28596374
    4. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
    5. BMPER-induced BMP signaling promotes coronary artery remodeling. PMID: 24373957
    6. BMPER appears to play a role in regulating both vessel density and cardiac development PMID: 23200275
    7. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin and epithelial leakage in vitro and in vivo. PMID: 23716395
    8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
    9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
    10. Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. PMID: 22144676
    11. BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. PMID: 21900199
    12. BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina. PMID: 21737784
    13. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. PMID: 20807528
    14. Cv2 enhances pro-BMP activity of Tsg. PMID: 19914233
    15. Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. PMID: 15188429
    16. crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. PMID: 17035289
    17. The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. PMID: 18644438
    18. Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. PMID: 18662983
    19. Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. PMID: 18789316
    20. Study demonstrates that as molar concentrations of Bmper exceed Bmp4, Bmper dynamically switches from an activator to an inhibitor of Bmp4 signaling. PMID: 19221194

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 中文成人无码精品久久久不卡 | 亚洲免费福利在线视频| 吃奶呻吟打开双腿做受视频| 亚洲精品成人区在线观看 | 中文字幕av中文字无码亚| 日韩精品一卡2卡3卡4卡新区| 国产萌白酱喷水视频在线观看| 国产无遮挡裸体免费视频在线观看| 男人边做边吃奶头视频| 狠狠狠色丁香综合婷婷久久| 免费国产黄线在线观看| 国产免费看插插插视频| 亚洲有无码av在线播放| 亚洲国产精品成人精品无码区蜜臀| 久久久久国色av免费观看性色| 国产精品亚洲欧美大片在线看| 日本肉体xxxx裸交| 亚洲国产成人久久综合电影| 玩弄丰满少妇人妻视频| 久久国产中文娱乐网| 天天做天天爱天天综合网 | 又色又爽又黄的gif动态图| 欧美成人精品三级网站视频| 无码精品人妻一区二区三区湄公河 | 玩弄丰满熟妇xxxxx性60| av无码久久久久不卡网站蜜桃| 国产真人做爰毛片视频直播| av亚欧洲日产国码无码| 丰满又黄又爽少妇毛片| 亚洲a∨无码男人的天堂| 边啃奶头边躁狠狠躁| 亚洲区小说区激情区图片区| 国产精品久久久久久久久鸭| 久久99精品久久久久久动态图| 强迫大乳人妻中文字幕| 色偷偷女人的天堂亚洲网| 久久这里只有精品首页| 日产精品高潮呻吟av久久| 久久婷婷五月综合色奶水99啪| 300部国产真实乱| 老子午夜精品无码|