在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Mouse Angiopoietin-related protein 2(ANGPTL2) ELISA kit

  • 中文名稱:
    小鼠血管生成素相關蛋白2(ANGPTL2)酶聯免疫試劑盒
  • 貨號:
    CSB-EL001710MO
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠血管生成素相關蛋白2(ANGPTL2)酶聯免疫試劑盒(CSB-EL001710MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的ANGPTL2含量。ANGPTL2是一種與血管生成素結構相似的蛋白,參與血管生成、脂質代謝和炎癥調節。其通過自分泌和旁分泌機制誘導內皮細胞出芽,在血管生成中發揮關鍵作用。研究顯示,ANGPTL2通過PirB激活Müller細胞,促進炎癥因子釋放,參與眼內炎癥。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,本試劑盒通過高特異性抗體對靶蛋白進行捕獲與檢測,操作便捷且重復性良好,可為體外研究ANGPTL2在肥胖、糖尿病、動脈粥樣硬化等疾病模型中的功能機制提供可靠工具,亦可用于評估藥物干預或基因編輯后生物樣本中ANGPTL2的動態變化,滿足基礎科研與藥物開發中的蛋白定量需求。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Angptl2 ELISA Kit; Arp2Angiopoietin-related protein 2 ELISA Kit; Angiopoietin-like protein 2 ELISA Kit
  • 縮寫:
    ANGPTL2
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse ANGPTL2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %96
    Range %91-102
    1:2Average %102
    Range %98-106
    1:4Average %89
    Range %84-94
    1:8Average %94
    Range %92-96
  • 回收率:
    The recovery of mouse ANGPTL2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 103101-106
    EDTA plasma (n=4)9591-100
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.221 2.157 2.189 2.032
    5001.510 1.466 1.488 1.331
    2500.896 0.888 0.892 0.735
    1250.502 0.494 0.498 0.341
    62.50.332 0.344 0.338 0.181
    31.20.284 0.295 0.290 0.133
    15.60.211 0.229 0.220 0.063
    00.151 0.163 0.157
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Induces sprouting in endothelial cells through an autocrine and paracrine action.
  • 基因功能參考文獻:
    1. ANGPTL2 up-regulation in skeletal myocytes accelerates muscle atrophy, and exercise-induced attenuation of ANGPTL2 expression in those tissues may partially explain how exercise training prevents sarcopenia. PMID: 29191837
    2. Angptl2(-/-) in paraquat-treated mice attenuated acute lung injury progression by reducing the number of total cells, total leukocytes, neutrophils and macrophages in bronchoalveolar lavage fluid and reducing inflammatory response through the inactivation of nuclear factor kappa B pathway. PMID: 29852175
    3. Kaempferol modulates the expression of ANGPTL2 to lessen the mastitis in mice. PMID: 29627690
    4. These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine. PMID: 28043948
    5. we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke. PMID: 27861531
    6. Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung. PMID: 27542805
    7. Angptl2 regulates not only adipose tissue metabolism but also bone metabolism PMID: 28285646
    8. findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection. PMID: 27402837
    9. Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration. PMID: 26839315
    10. ANGPTL2 promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin resistance. PMID: 26132105
    11. It plays a role in tumor progression. PMID: 25090954
    12. Angptl2 induces proinflammatory responses in peritoneal macrophages and monocytes. PMID: 26435501
    13. In angptl2 knockdown mice, ACh-mediated endothelium-dependent vasodilation was greater than in WT mice. Lack of angptl2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice. PMID: 25128474
    14. knockdown of angptl2 may be protective against ANG II-induced cerebral endothelial dysfunction; it favors the production of NO increasing endothelial cell resistance to stress. PMID: 25527773
    15. Angptl2 expression was reduced in PHD3(-/-) bone-marrow-derived macrophages under stress conditions. PHD3 affects the production of Angptl2 and additionally influences the response toward this apoptosis-modulating factor. PMID: 24626957
    16. Angptl2-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression. PMID: 24258150
    17. Endothelial cell-derived Angptl2 accelerates vascular inflammation by activating proinflammatory signaling in endothelial cells and increasing macrophage infiltration, leading to endothelial dysfunction and atherosclerosis progression. PMID: 24526691
    18. periodic expression of ANGPTL2 is regulated by a molecular clock PMID: 23469106
    19. Our findings demonstrated Angptl2 to be upregulated in corneal inflammation, and highlight that corneal hemangiogenesis and lymphangiogenesis may be driven by Angptk2 overexpression via macrophage infiltration and IL-1beta expression. PMID: 23702783
    20. These findings may provide insight into the molecular mechanisms of the increased expression of Angptl2 and TGF-beta1 in obesity. PMID: 23261458
    21. mediates endotoxin-induced retinal inflammation through the activation of NF-kappaB signaling pathway PMID: 22868908
    22. Macrophage-derived Angptl2 contributes to abdominal aortic aneurysm development by inducing inflammation and degradation of extracellular matrix in the vessel wall. PMID: 22556334
    23. demonstrate the ability of NOS2 to inhibit hyperoxia-induced Ang2 production and thereby decrease Ang2-induced tissue injury PMID: 22227562
    24. tumor cell-derived ANGPTL2 drives metastasis and provided an initial proof of concept for blockade of its action as a strategy to antagonize the metastatic process. PMID: 22345152
    25. keratinocyte-derived Angptl2 functions in dermatomyositis pathogenesis by inducing chronic inflammation in skin tissue. PMID: 22281496
    26. Data suggest that angiopoietin-like protein 2 (Angptl2) contributes to increased carcinogenesis and metastasis and represents a novel target to antagonize these pathologies. PMID: 22042794
    27. Tumor necrosis factor-alpha up-regulates Angptl2 mRNA expression via PI3K/Foxo1 pathway in adipocytes, which may be involved in obesity-induced inflammation and insulin resistance PMID: 21501655
    28. This work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling. PMID: 18514180
    29. Data suggest that interaction of ANG2, a proangiogenic factor, with its receptor Tie2 promotes neural progenitor cell differentiation into neuronal lineage cells. PMID: 19553662
    30. Angiopoietin-like protein 2 (Angptl2) was secreted by adipose tissue and that its circulating level was closely related to adiposity, systemic insulin resistance, and inflammation in mice. PMID: 19723494

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 組織特異性:
    Widely expressed in heart, tongue, lung and skeletal muscle. Also found in lower levels in kidney, epididymis and testis.
  • 數據庫鏈接:


主站蜘蛛池模板: 色婷婷六月亚洲综合香蕉| 欧洲人免费视频网站在线| 综合在线视频精品专区| 亚洲国产成人久久一区久久| 一本无码人妻在中文字幕| 色综合久久网| 中文在线а√天堂| 无码人妻丰满熟妇区免费| 亚洲国产成人超a在线播放| 国产性夜夜春夜夜爽免费下载| 男女18禁啪啪无遮挡| 69sex久久精品国产麻豆| 中文字幕欧美日韩va免费视频| 性欧美牲交在线视频| 亚洲中文无码永久免| 亚洲蜜桃精久久久久久久久久久久| 久久综合伊人77777| 国产a√精品区二区三区四区| 色欲天天婬色婬香综合网完整版| 午夜人性色福利无码视频在线观看| 两女女百合互慰av赤裸无遮挡| 国产午夜视频在线观看| 疯狂做受xxxx高潮欧美日本| 免费国产在线精品一区不卡| 亚洲另类色区欧美日韩图片| 精品国产精品国产偷麻豆 | 午夜天堂一区人妻| 日本丰满白嫩大屁股ass| 亚洲成a人片77777国产| 中文字幕 乱码 中文乱码视频| 色婷婷香蕉在线一区二区| 性夜夜春夜夜爽aa片a| 超碰97人人做人人爱亚洲尤物| 国产精品久久久久久不卡盗摄| 又硬又粗又大一区二区三区视频| 久久久久99精品成人片牛牛影视| 国产高跟黑色丝袜在线| 久久综合香蕉国产蜜臀av | 一进一出抽搐gif| 国产爆乳无码视频在线观看| 日韩免费无码成人久久久久久片 |