在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse ADM2(ADM2) ELISA kit

Mouse ADM2(ADM2) ELISA kit

  • 中文名稱：
    小鼠ADM2(ADM2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL001371MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠ADM2(ADM2)酶聯免疫試劑盒（CSB-EL001371MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的ADM2含量。小鼠ADM2（腎上腺髓質素2）是一種編碼降鈣素基因相關肽（CGRP）的基因，其在心血管穩態、催乳素釋放、抗利尿等方面發揮作用。研究顯示，ADM2通過基因敲除和條件性敲除小鼠模型，有助于理解其在心血管疾病和腫瘤發生中的作用機制。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，本試劑盒適用于科研領域中對小鼠模型中ADM2表達動力學的研究，例如在肥胖、糖尿病或高血壓等疾病機制探索中，通過檢測血清、血漿循環標志物或特定組織（如脂肪、心肌）勻漿中的ADM2濃度，定量評估其與生理病理進程的關聯性。為體外實驗提供可靠的數據支持，助力于基礎醫學研究與藥物開發中的靶點功能解析。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Adm2 ELISA kit; Am2Protein ADM2 ELISA kit; Intermedin) [Cleaved into: Adrenomedullin-2 ELISA kit; AM2 ELISA kit; Intermedin-long ELISA kit; IMDL); Intermedin-short ELISA kit; IMDS)] ELISA kit
  • 縮寫：
    ADM2
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    62.5 pg/mL-4000 pg/mL
  • 靈敏度：
    15.6 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.; May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
  • 基因功能參考文獻：
    1. IMD may be an important self-protective factor in response to sepsis. PMID: 29980671
    2. Intermedin attenuated neointima formation in the mouse model of common carotid-artery ligation injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway. PMID: 29053988
    3. results indicate that endogenous AM2 might be involved in energy metabolism in adipocytes through the upregulation of UCP1 expression PMID: 26786353
    4. ADM2 enhances subcutaneous White Adipose Tissue beiging via a direct effect by activating the CRLR.RAMP1-cAMP/PKA and p38 MAPK pathways in white adipocytes and via an indirect effect by stimulating alternative M2 polarization in macrophages. PMID: 27621315
    5. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
    6. IMD reduces bone resorption by inhibiting osteoblast apoptosis, decreasing the RANKL/OPG ratio and the expression of M-CSF, and inhibiting osteoclast maturation and differentiation. PMID: 26398911
    7. Adrenomedullin-2/intermedin(8-47) ameliorates early ischemia/reperfusion injury in mouse lungs by protecting the integrity of the blood-air barrier and by potently reducing leukocyte influx into the alveolar space PMID: 25290159
    8. Intermedin attenuates macrophage foam-cell formation via tristetraprolin-mediated degradation of CD36 mRNA. PMID: 24253523
    9. increased stability of PTEN by intermedin leads to SR-A inhibition in macrophages, which ameliorates foam-cell formation and atherosclerosis in apoE(-/-) mice. PMID: 22841663
    10. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2. PMID: 22563471
    11. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes PMID: 14615490
    12. Our data suggest that IMD acutely augments cardiomyocyte contractile function through, at least in part, a protein kinase C- and protein kinase A-dependent mechanism. PMID: 16763098
    13. tissue adrenomedullin 2 intermedin content was positively correlated with the diastolic blood pressure and negatively correlated with pulse pressure PMID: 19680258
    14. IMD is a novel hypoxia-induced gene and a potential interventional agent for the improvement of endothelial barrier function in systemic inflammatory responses and hypoxia-induced vascular leakage. PMID: 19684198

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 組織特異性：
    High expression detected in the submaxillary gland, kidney, stomach, and mesentery, followed by the pituitary, lung, pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the intermediate lobe of the pituitary, with sporadic in the anterior
  • 數據庫鏈接：


主站蜘蛛池模板： 色噜噜亚洲男人的天堂www| 18禁黄无遮挡网站免费| 久久综合五月丁香久久激情| 亚洲国产成人在人网站天堂| 无码专区久久综合久中文字幕| 最新亚洲春色av无码专区| 日韩无套内射视频6| 真实国产乱子伦在线视频| 亚洲日本成本人观看| 岛国av无码免费无禁网站| 日日av色欲香天天综合网| 国产成人人综合亚洲欧美丁香花| 亚洲精品国产成人| 伊人www22综合色| 人与人性恔配视频免费| 国产又黄又湿无遮挡免费视频| 性做久久久久久久| 国产精品99久久久久久www| 黑人巨大无码中文字幕无码| 亚洲国产精品无码久久| 色橹橹欧美在线观看视频高清| 国自产拍偷拍精品啪啪模特 | 久久人妻精品白浆国产| 永久免费的av在线电影网无码| 直接观看黄网站免费视频| 第一亚洲中文久久精品无码| 成人婷婷网色偷偷亚洲男人的天堂| 久久久久欧美精品| 果冻传媒2021精品一区| 久久精品国产亚洲αv忘忧草| 欧美变态另类刺激| 欧美xxxx做受欧美1314 | 午夜尤物禁止18点击进入| 伊人久久大香线蕉av五月天| 国产自产v一区二区三区c| 国产a三级久久精品| 日本人妻精品免费视频| 亚洲色精品aⅴ一区区三区| 欧美最猛黑人xxxx黑人猛交| 亚洲精品一区二区国产精华液| 美女扒开大腿让男人桶|