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Mouse β2-microglobulin,BMG/β2-MG ELISA Kit

  • 中文名稱(chēng):
    小鼠β2微球蛋白(BMG/β2-MG)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E13053m
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠β2微球蛋白(BMG/β2-MG)酶聯(lián)免疫試劑盒(CSB-E13053m)為競(jìng)爭(zhēng)法ELISA試劑盒,定量檢測(cè)血清、血漿、尿液、組織勻漿樣本中的B2M含量。B2M即β2-微球蛋白,是MHCⅠ類(lèi)分子的輕鏈,廣泛存在于有核細(xì)胞表面。其在免疫識(shí)別、抗原呈遞等方面發(fā)揮重要作用。研究中,它與多種疾病如腫瘤、自身免疫病相關(guān),通過(guò)檢測(cè)其水平變化等機(jī)制,助力疾病的診斷、病情監(jiān)測(cè)及預(yù)后評(píng)估。試劑盒檢測(cè)范圍為0.156 μg/ml-10 μg/ml.,適用于多種科研場(chǎng)景,包括但不限于腎臟疾病模型中腎小管功能評(píng)估、免疫系統(tǒng)相關(guān)基因敲除動(dòng)物的β2 - MG動(dòng)態(tài)監(jiān)測(cè)、腫瘤微環(huán)境中免疫調(diào)控機(jī)制研究以及尿液生物標(biāo)志物探索等領(lǐng)域。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名:
    B2mBeta-2-microglobulin ELISA kit
  • 縮寫(xiě):
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類(lèi)型:
    serum, plasma, urine, tissue homogenates
  • 檢測(cè)范圍:
    0.156 μg/ml-10 μg/ml.
  • 靈敏度:
    0.156 μg/ml.
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Immunology
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Competitive
  • 精密度:

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度:

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse BMG/β2-MG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

    Sample

    Serum(n=4)

    1:1

    Average %

    88

    Range %

    83-93

    1:2

    Average %

    92

    Range %

    85-98

    1:4

    Average %

    86

    Range %

    82-91

    1:8

    Average %

    93

    Range %

    85-99

  • 回收率:

    The recovery of mouse BMG/β2-MG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    93

    87-98

    EDTA plasma (n=4)

    99

    92-106

  • 標(biāo)準(zhǔn)曲線:

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    μg/ml

    OD1

    OD2

    Average

    10

    0.219

    0.230

    0.224

    5

    0.305

    0.317

    0.311

    2.5

    0.445

    0.428

    0.436

    1.25

    0.538

    0.572

    0.555

    0.625

    0.815

    0.821

    0.818

    0.312

    1.099

    1.053

    1.076

    0.156

    1.503

    1.484

    1.494

    0

    2.235

    2.125

    2.180

  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • 基因功能參考文獻(xiàn):
    1. When no programmed delay interval was imposed, the beta2m-deficient mice acquired the task as fast as controls, suggesting that discrimination of left and right positions is not impaired by the total loss of hippocampal asymmetry. beta2m-deficient mice made fewer correct responses than control mice when variable delay was imposed, suggesting that the asymmetry of hippocampal circuitry plays an important role in working... PMID: 28039089
    2. The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M. PMID: 26780548
    3. Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients. PMID: 25775354
    4. systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis PMID: 26147761
    5. Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment. PMID: 25782992
    6. We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens. PMID: 23531237
    7. The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN and gFAP expression in different sections of the brain in mice. PMID: 24237146
    8. MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex PMID: 24272393
    9. Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits. PMID: 23959708
    10. This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis PMID: 22335434
    11. Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms. PMID: 23089196
    12. This gene is known to be important for immune responses and may potentially regulate alcohol consumption. PMID: 21309947
    13. Data show that NK subsets bearing Ly49s, which bind "self-MHC" were found to be the dominant subset responsible for beta2m(-/-) BMC rejection. PMID: 22184406
    14. Skin graft rejection induced by B2m-derived minor transplantation antigens involves Th2-dependent eosinophilic rejection, IFN-gamma dependent mechanisms, and Fas-Fas ligand interactions. PMID: 12077281
    15. beta-2 microglobulin knockout-anti-asialoGM1 mice exhibit improved hemodynamics and cardiac contractile function after cecal ligation and puncture that may account, in part, for survival benefit PMID: 14630624
    16. Rag1 deficiency in Hfe knock-out mice leads to heightened iron overload, mainly in the liver, whereas the heart and pancreas are relatively spared compared with beta2mRag1(-/-) mice. PMID: 14656877
    17. Beta 2 microglobulin deficient mice react normally to endotoxin and their hepatocytes react normally to IL-6. PMID: 15192150
    18. Results show that a seven-residue segment of human beta2-microglobulin (beta2M), not found in mouse beta2M, is sufficient to convert beta2M to the amyloid state, and that specific residue interactions are crucial to the conversion. PMID: 15249659
    19. Knockout mice represent an instructive model of spontaneous iron overload resembling genetic hemochromatosis. PMID: 15315790
    20. Experimental autoimmune encephalomyelitis in beta 2-microglobulin(beta2m)-deficient mice is significantly more severe, with a 10-fold increased mortality in beta2m-null mice as compared to wild-type C57BL/6 mice. PMID: 15837577
    21. The results suggested that beta2m as well as TAP was necessary for the transportation of blastocyst MHC from endoplasmic reticulum to cell surfaces through the Golgi apparatus, similar to other MHC class I molecules. PMID: 15896332
    22. thermodynamic stabilities of the beta2m variants PMID: 16229893
    23. Data provide a crystallographic comparison of H-2D(b) in complex with gp33 peptide and either human or mouse beta(2)microglobulin. PMID: 16375919
    24. acquisition of an impaired breeding phenotype (IBP) as a result of the knockout of beta-2 microglobulin (B2M) directly implicates B2M in the reproductive cycle of mice PMID: 17442853
    25. voluntary wheel running exercise-induced liver beta2-microglobulin expression is related to lower IgG clearance in the blood PMID: 17524613
    26. macrophages have a role in the formation and degradation of beta2-microglobulin amyloid fibrils PMID: 17686767
    27. Alterations in beta 2-microglobulin influence the ability of T cell receptors to engage class-I histocompatibility antigen H-2Kb during normal T cell physiology. PMID: 17785793
    28. beta 2m-associated effect other than FcRn prolongs the survival of both IgG and albumin PMID: 18375831
    29. Data show that cerebella from adult mice deficient for H2-D1 and H2-K1, and for beta2-microglobulin gene are of deficient elimination of supernumerary climbing fiber synapses on their Purkinje cells. PMID: 18418877
    30. A natural killer T (NKT) cell subset is restricted by a beta-2 microglobulin-independent form of CD1d antigen and may induce bronchial hyperreactivity. PMID: 18802058
    31. these studies clearly indicate the importance of a beta(2)-microglobulin-dependent but CD8 T-cell- and iNK T-cell-independent mechanism critical for survival during K. pneumoniae bacteremia. PMID: 18981251
    32. the mechanism by which beta(2)-microglobulin negatively regulates gammadelta T cell homeostasis remains to be determined PMID: 19201842
    33. results indicate that beta(2)m may be involved in proliferation of uNK cells in the metrial gland, and that beta(2)m may affect the maturation of uNK cells in the decidua basalis. PMID: 19262044
    34. NKT cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d PMID: 19833737

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  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Beta-2-microglobulin family
  • 數(shù)據(jù)庫(kù)鏈接:

    KEGG: mmu:12010

    STRING: 10090.ENSMUSP00000099534

    UniGene: Mm.163



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