在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human α2-Antiplasmin,α2-AP ELISA Kit

Human α2-Antiplasmin,α2-AP ELISA Kit

  • 中文名稱：
    人α2抗纖溶酶(α2-AP)酶聯免疫試劑盒
  • 貨號：
    CSB-E09452h
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人α2抗纖溶酶(α2-AP)酶聯免疫試劑盒（CSB-E09452h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的SERPINF2含量。SERPINF2是一個靶點。它在人體生理活動中有著重要意義。目前研究主要聚焦于其在細胞信號傳導、組織修復等方面的機制。深入探討它在相關疾病發生發展中扮演的角色，有望為研發針對性的治療藥物和策略提供理論支撐。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于基礎醫學研究中纖溶系統功能評估、血栓相關疾病機制探索、肝臟合成功能研究及遺傳性纖溶異常疾病的體外分析，同時可為抗凝藥物開發提供可靠的生物標志物檢測方案。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    A2AP ELISA Kit; A2AP_HUMAN ELISA Kit; AAP ELISA Kit; Alpha 2 antiplasmin ELISA Kit; Alpha 2 antiplasmin pigment epithelium derived factor ELISA Kit; Alpha 2 AP ELISA Kit; ALPHA 2 PI ELISA Kit; Alpha 2 plasmin inhibitor ELISA Kit; Alpha 2 plasmin inhibitor deficiency ELISA Kit; Alpha-2-antiplasmin ELISA Kit; Alpha-2-AP ELISA Kit; Alpha-2-PI ELISA Kit; Alpha-2-plasmin inhibitor ELISA Kit; Antiplasmin deficiency ELISA Kit; API ELISA Kit; Plasmin inhibitor deficiency ELISA Kit; PLI ELISA Kit; Serine (or cysteine) peptidase inhibitor; clade F; member 2 ELISA Kit; Serine (Or cysteine) peptidase inhibitor; clade F; member 2; isoform CRA_c ELISA Kit; Serine (or cysteine) proteinase inhibitor; clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2 ELISA Kit; Serine (Or cysteine) proteinase inhibitor; clade F; member 2 ELISA Kit; Serine or cysteine peptidase inhibitor clade F member 2 ELISA Kit; Serpin F2 ELISA Kit; Serpin peptidase inhibitor clade F ELISA Kit; Serpin peptidase inhibitor; clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2 ELISA Kit; SERPINF2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human α2-AP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %88
    Range %84-93
    1:2Average %85
    Range %81-91
    1:4Average %92
    Range %88-100
    1:8Average %95
    Range %91-99
  • 回收率：
    The recovery of human α2-AP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8983-94
    EDTA plasma (n=4)9590-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.272 2.346 2.309 2.214
    5001.476 1.491 1.484 1.389
    2500.863 0.892 0.878 0.783
    1250.448 0.479 0.464 0.369
    62.50.268 0.251 0.260 0.165
    31.20.187 0.178 0.183 0.088
    15.60.169 0.159 0.164 0.069
    00.097 0.092 0.095 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
  • 基因功能參考文獻：
    1. alpha2AP has a profibrotic effect probably not by the action as a plasmin inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis PMID: 26743600
    2. This review presents recent findings regarding the main aspects of the natural heterogeneity of A2AP with particular focus on the functional and possible clinical implications. [review] PMID: 26626994
    3. Possession of the alpha2AP 407Lys allele was negatively associated with AAA, and thus changes in alpha2AP may affect aneurysm growth and development. PMID: 25065555
    4. Changes in plasma A2AP are associated with cardiovascular disease event presentation. PMID: 26088309
    5. A significant correlation was found between soluble fibroblast activation protein levels and alpha2-antiplasmin cleavage in coronary thrombosis. PMID: 25464232
    6. increased N-terminal cleavage of alpha2AP may have a role in liver cirrhosis PMID: 24034420
    7. FXIII-A has a functional role through exposure on the activated platelet membrane where it exerts antifibrinolytic function by cross-linking alpha2AP to fibrin PMID: 25331118
    8. Data suggest serum A2AP (SERPINF2) level can serve as biomarker for diabetic retinopathy; levels of A2AP (but not fibrinogen, plasminogen, or plasminogen activator inhibitor 1) are up-regulated in hyperglycemic type 1 diabetes with retinopathy. PMID: 24818165
    9. protective mediator during gram-negative (pneumo)sepsis, limiting bacterial growth, inflammation, tissue injury, and coagulation PMID: 23992406
    10. Study revealed that plasmin was present in tumor tissue, and that it was responsible for processing progalanin to galanin(1-20) in the extracellular environment. PMID: 21707521
    11. Data suggest that decreased amounts of alpha2-plasmin inhibitor in plasma vs serum ex vivo may reflect reduced factor XIII (FXIII) in vivo; thus, plasma vs serum alpha2-plasmin inhibitor may be useful diagnostic marker for severe FXIII deficiency. PMID: 22205503
    12. fibrinolysis is enhanced by inhibiting enzymatic cleavage of precursor alpha2-antiplasmin PMID: 21251197
    13. Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. PMID: 21486949
    14. Levels of free full-length alpha2AP were decreased in myocardial infarction (MI); the percentage of C-terminally cleaved alpha2AP was unaltered, and Arg407Lys did not influence alpha2AP levels or MI risk. PMID: 21505192
    15. the antifibrinolytic function of FXIII is independent of fibrin-fibrin cross-linking and is expressed exclusively through alphaAP. PMID: 21471521
    16. ADAMTS13 inactivation by plasmin as a potential cause of thrombotic thrombocytopenic purpura PMID: 20553378
    17. deficiency in patients with Philadelphia chromosome-positive haematologic cancer receiving imatinib mesylate PMID: 19492163
    18. OPN is highly susceptible to cleavage near its integrin-binding motifs, and the protein is a novel substrate for plasmin and cathepsin D PMID: 20071328
    19. FXIIIa substrate, A2AP, sequences suggests that the residue located two positions beyond the reactive glutamine is not conserved. this position makes important contributions to effective FXIIIa-A2AP interactions PMID: 19691486
    20. Multiple Lys residues within alpha 2-antiplasmin contribute, perhaps in a zipper-like fashion, to its binding to the in-tandem, multikringle array that configures the plasmin heavy chain. PMID: 12549929
    21. Alpha2-antiplasmin has an important role in acute pulmonary embolism PMID: 12911586
    22. the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin PMID: 17317851
    23. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate PMID: 17883703
    24. Hydroxyethyl starch (HES) dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. PMID: 17890952
    25. Sequencing analysis revealed the presence of two alpha2-PI gene variations, both in the second half of exon 10: a frameshift mutation and a G to A transition at nucleotide 11337 in codon 407. PMID: 17961166
    26. Thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin are not markers for recanalization in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. PMID: 18048863
    27. Plasmin in nephrotic urine activates the epithelial sodium channel PMID: 19073825

    顯示更多

    收起更多

  • 相關疾病：
    Alpha-2-plasmin inhibitor deficiency (APLID)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數據庫鏈接：

    HGNC: 9075

    OMIM: 262850

    KEGG: hsa:5345

    STRING: 9606.ENSP00000321853

    UniGene: Hs.159509



主站蜘蛛池模板： 日韩视频在线观看| 精品国产一区二区三区免费| 久久久久99精品成人片三人毛片| 国产l精品国产亚洲区久久| 日韩理论午夜无码| 天天躁久久躁日日躁| 日本xxx在线观看免费播放| 中文字幕人妻无码视频| 国产午夜福利100集发布| 国产成人精品视频网站| 亚洲国产成人精品无码区一本| 中文字幕在线无码一区二区三区| 色狠狠色噜噜av天堂一区| 日本特黄aaaaaa片在线观看| 天天天天躁天天爱天天碰 | 国产成人8x人网站视频在线观看| 特级西西人体444www高清大胆| 风韵丰满熟妇啪啪区老老熟妇| av狠狠色超碰丁香婷婷综合久久| 国产亚洲日本精品无码| 五月天中文字幕mv在线| 国产精品视频免费一区二区| 国产成人mv视频在线观看| 97无码精品综合| 亚洲精品无码av中文字幕| 日本夜爽爽一区二区三区| 醉酒后少妇被疯狂内射视频 | 午夜免费视频| 国产日韩未满十八禁止观看| 国产高清乱理伦片中文小说| 欧美激情性做爰免费视频| 亚洲国产精品国自产拍电影| 最近最好的中文字幕2019免费 | 亚洲蜜芽在线精品一区| 亚洲天堂男人影院| 国产做爰xxxⅹ高潮视频12p| 精品无人乱码高清在线观看 | 国产啪精品视频网站免费尤物| 亚洲成av人片在线观看www| 少妇高潮流白浆在线观看| 日本高清不卡aⅴ免费网站|