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  4. Human thymus expressed chemokine,TECK ELISA Kit

Human thymus expressed chemokine,TECK ELISA Kit

  • 中文名稱：
    人胸腺表達趨化因子(TECK/CCL25)酶聯免疫試劑盒
  • 貨號：
    CSB-E09189h
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人胸腺表達趨化因子(TECK/CCL25)酶聯免疫試劑盒（CSB-E09189h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL25含量。CCL25是一種趨化因子。它在免疫系統等方面有著重要背景，可參與調節白細胞遷移等過程。研究機制上，主要通過與相應受體結合，激活細胞內信號通路，進而調控細胞行為，在炎癥、腫瘤等疾病研究中受關注。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，本試劑盒適用于科研領域的基礎研究，例如探究TECK/CCL25在免疫調節、黏膜免疫應答中的分子機制，或用于評估實驗模型中該因子在疾病發生發展中的動態變化，為免疫相關疾病機制解析、藥物靶點篩選及生物標志物研究提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    A130072A22Rik ELISA Kit; C-C motif chemokine 25 ELISA Kit; CCL 25 ELISA Kit; CCL25 ELISA Kit; CCL25_HUMAN ELISA Kit; Chemokine (C C motif) ligand 25 ELISA Kit; Chemokine (CC motif) ligand 25 ELISA Kit; Chemokine C C motif ligand 25 ELISA Kit; Chemokine CC motif ligand 25 ELISA Kit; Chemokine TECK ELISA Kit; Ck beta 15 ELISA Kit; Ckb 15 ELISA Kit; Ckb15 ELISA Kit; MGC125074 ELISA Kit; MGC150327 ELISA Kit; SCY A25 ELISA Kit; SCYA 25 ELISA Kit; SCYA25 ELISA Kit; Small inducible cytokine A25 ELISA Kit; Small inducible cytokine A25 isoform 1 precursor ELISA Kit; Small inducible cytokine A25 isoform 2 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 25 ELISA Kit; Small inducible cytokine subfamily A Cys Cys member 25 ELISA Kit; Small inducible cytokine subfamily A; member 25 ELISA Kit; Small-inducible cytokine A25 ELISA Kit; TECK ELISA Kit; TECKvar ELISA Kit; Thymus expressed chemokine ELISA Kit; Thymus-expressed chemokine ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TECK in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 94
    Range % 87-98
    1:2 Average % 100
    Range % 96-104
    1:4 Average % 89
    Range % 84-94
    1:8 Average % 95
    Range % 89-100
  • 回收率：
    The recovery of human TECK spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 91 85-97
    EDTA plasma (n=4) 104 97-110
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1600 2.684 2.564 2.624 2.498
    800 2.011 1.937 1.974 1.848
    400 1.374 1.339 1.357 1.231
    200 0.945 0.908 0.927 0.801
    100 0.528 0.516 0.522 0.396
    50 0.320 0.307 0.314 0.188
    25 0.238 0.231 0.235 0.109
    0 0.129 0.123 0.126 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
  • 基因功能參考文獻：
    1. CCL25 was able to induce proteoglycan and collagen type I production in anulus fibrosus-derived cells. PMID: 30060561
    2. It plays a pathogenic role in liver diseases and it will be a therapeutic target of the diseases. PMID: 27795503
    3. TECK was shown to be expressed by osteoblasts, and its receptor, CCR9, by osteoclast precursors. TECK increased P. gingivalis LPS-induced osteoclast numbers in an in vitro osteoclast formation assay using osteoclast precursors. T PMID: 26921718
    4. that CCL25/CCR9 signal may provide cancer cells with chemotactic abilities through influencing several epithelial-mesenchymal transitionmarkers PMID: 27008282
    5. CCR9/CCL25 interactions are not only involved in colitis pathogenesis but also correlate with colonic inflammatory burden; further supporting the existence of overlapping mucosal lymphocyte recruitment pathways between the inflamed colon and liver. PMID: 26873648
    6. CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID: 26472015
    7. Studies indicate important roles played by chemokine ligand 25 (CCL25)/chemokine receptor 9 (CCR9) in tumorigenesis, tumor chemoresistance and metastasis. PMID: 26879872
    8. CCL25 mRNA and protein levels were significantly increased in the nasopharyngeal carcinoma group compared with the control group. PMID: 26279399
    9. CCR9-CCL25 interaction promoted proliferation and suppressed apoptosis of non-small cell lung cancer cells by activating the PI3K/Akt pathway. PMID: 25691296
    10. High CCL25 expression is associated with the pathogenesis of ulcerative colitis. PMID: 24936795
    11. Expression of CCR9 and CCL25, the only natural ligand of CCR9, was significantly higher (p<0.0001) in NSCLC tissues and serum respectively, compared to their respective controls. PMID: 25296976
    12. TECK derived from endometrial stromal cell and macrophages upregulates the number and function of Tregs in the ectopic milieu. PMID: 25275597
    13. CCL25 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. PMID: 12949249
    14. CCL25 and CCR9 regulate colorectal cancer progression and invasion. PMID: 22863617
    15. cell migration assays revealed that mesenchymal stromal cells (MSCs) have tropism toward multiple myeloma (MM) cells, and CCL25 was identified as a major MM cell-produced chemoattractant for MSCs. PMID: 22102554
    16. We provide the first evidence that CCR9 and its natural ligand CCL25 are highly expressed by ovarian cancer tissue and their expression correlates with histological subtypes. PMID: 21637913
    17. CCL25 enhanced the expression of MMP-1, -9, -11 and -13 active proteins by BrCa cells in a CCR9-dependent fashion. PMID: 21344163
    18. CCL25 may be involved in the differentiation of monocytes to macrophages particularly in rheumatoid arthritis PMID: 20738854
    19. over-expressed TECK interacts with CCR9 on the endometrial stromal cells in the endometriotic milieu, which may contribute to the onset and progression of endometriosis. PMID: 20081876
    20. demonstrate a unique pattern of regulation for CCL25 and suggest a role for caudal type homeo box proteins in regulating CCL25 transcription PMID: 16517733
    21. Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin alpha4beta1. PMID: 17510295
    22. High expression may explain high incidence of melanoma metastis to the small intestine. PMID: 18245522
    23. There was a robust migration of specific IgA- and IgM-antibody-secreting cells induced by Salmonella vaccination toward the mucosal chemokines CCL25 and CCL28 PMID: 19003934

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
  • 數據庫鏈接：

    HGNC: 10624

    OMIM: 602565

    KEGG: hsa:6370

    STRING: 9606.ENSP00000375086

    UniGene: Hs.310511



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