在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human progesterone induced blocking factor (PIBF) Elisa kit

  • 中文名稱:
    人孕激素誘導(dǎo)阻斷因子(PIBF)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E12872h
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人孕激素誘導(dǎo)阻斷因子(PIBF)酶聯(lián)免疫試劑盒(CSB-E12872h)為競爭法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的PIBF1含量。試劑盒檢測范圍為0.78 ng/ml- 50 ng/ml,靈敏度為0.195 ng/ml。廣泛應(yīng)用于生殖生物學(xué)、免疫學(xué)等領(lǐng)域的基礎(chǔ)研究,特別適用于探索妊娠相關(guān)疾病的分子機(jī)制、胚胎著床微環(huán)境調(diào)控以及母胎界面免疫應(yīng)答等課題,為體外培養(yǎng)模型、動(dòng)物實(shí)驗(yàn)或人類樣本中的PIBF動(dòng)態(tài)變化分析提供可靠工具,所有檢測結(jié)果僅用于科學(xué)研究目的。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    PIBF1; C13orf24; PIBF; Progesterone-induced-blocking factor 1; Centrosomal protein of 90 kDa; CEP90
  • 縮寫:
    PIBF1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.78 ng/ml - 50 ng/ml
  • 靈敏度:
    0.195 ng/ml
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Others
  • 測定原理:
    quantitative
  • 測定方法:
    Competitive
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展:
    PIBF1是一種由基因PIBF1編碼的蛋白質(zhì),具有重要的免疫調(diào)節(jié)和抗炎作用。最近的研究表明,PIBF1在某些自身免疫性疾病中發(fā)揮了重要作用,如自身免疫性病變、重癥肌無力和系統(tǒng)性紅斑狼瘡等。此外,PIBF1還參與了腫瘤的免疫逃逸和轉(zhuǎn)移過程。
  • 功能:
    Plays a role in ciliogenesis.; Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2.; The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein.
  • 基因功能參考文獻(xiàn):
    1. We found at high levels of expression of PIBF protein in epithelial ovarian cancer patients. These data demonstrate that tumor cells can secrete PIBF to escape the immune system PMID: 29962287
    2. blood and placental tissue level expression of PIBF is concordant and correlates with both progesterone receptor expression status as well as final pregnancy outcome PMID: 27728856
    3. this study shows that preterm birth may be predictable at 24-28 gestational week by lower than normal pregnancy PIBF values PMID: 27479613
    4. B cells are a significant producer of PIBF1 in human choriodecidua in late gestation. Preterm labor was associated with a lower level of active PIBF1 in late gestation choriodecidua. PMID: 27918564
    5. PIBF plays a role in both normal pregnancy and tumor biology. PMID: 20367622
    6. PIBF promotes proliferation, migration, and invasion of human glioblastoma cells. PMID: 28168193
    7. These data show that exposure to an allogeneic stimulus is not needed to cause a marked rise in PIBF, merely progesterone alone is sufficient. PMID: 26634256
    8. Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth. PMID: 25818991
    9. progesterone-induced blocking factor is intracellularly expressed by the cultured cells from Glioblastoma PMID: 24474429
    10. Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway PMID: 25218441
    11. decreased kisspeptin and PIBF expressions in trophoblasts and deciduas are associated with recurrent spontaneous abortion PMID: 24225150
    12. reduced expression during late pregnancy and resorption PMID: 24325791
    13. Data indicate that silencing of progesterone-induced blocking factor (PIBF) increased invasiveness as well as MMP-2,-9 secretion of HTR8/SVneo trophoblast, and decreased those of HT-1080 cells. PMID: 23807209
    14. CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation. PMID: 23110211
    15. Suggest that urinary PIBF levels may predict graft rejection in transplant recipients. PMID: 22172828
    16. increased serum levels after dydrogesterone supplementation in women with threatened preterm delivery; positive correlation with the length of gestation PMID: 22032897
    17. CEP90 was characterized as a component of pericentriolar satellites. PMID: 21224392
    18. PIBF affects the expression of leptin and its receptor, and PIBF expression is inversely related to trophoblast invasiveness. PMID: 21632119
    19. promotes secretion of type 2 cytkines by activated lymphocytes from pregnant woman PMID: 19371956
    20. The 48-kDa N-terminal part of PIBF is biologically active, and the part of the molecule responsible for modulating natural killer cell activity is encoded by exons 2-4. PMID: 14634107
    21. PIBF production is a characteristic feature of normal pregnancy, and determination of PIBF concentration in urine might be of use for the diagnosis of threatened premature pregnancy termination. PMID: 15269099
    22. progesterone induced blocking factor overexpression is associated with breast neoplasms PMID: 15305375
    23. PIBF phosphorylates PKC via binding to the IL-4R, without affecting intracellular Ca(++). These findings explain the mechanism by which PIBF supports a Th2 dominant cytokine pattern. PMID: 16433831
    24. PIBF concentrations in urine and serum of patients with threatened abortion were significantly lower than in healthy pregnant women. PMID: 19290853

    顯示更多

    收起更多

  • 相關(guān)疾病:
    May be associated with microcephaly.
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Secreted.; [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Secreted.; [Isoform 4]: Secreted.
  • 組織特異性:
    Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. Expressed in the first trimester pregnancy decidua. Localized to extravillous cytotrophoblast (at protein level). Also f
  • 數(shù)據(jù)庫鏈接:

    HGNC: 23352

    OMIM: 607532

    KEGG: hsa:10464

    STRING: 9606.ENSP00000317144

    UniGene: Hs.441926



主站蜘蛛池模板: 吃奶摸下高潮60分钟免费视频| 国产成人一区二区三区免费| 嫩草欧美曰韩国产大片| 中文无码一区二区三区在线观看| 少妇激情一区二区三区视频小说| 国产精品99久久免费黑人人妻 | 亚洲老熟女性亚洲| 丰满人妻熟妇乱又伦精品| 精品熟人妻一区二区三区四区不卡 | 无码高潮又爽又黄a片软件| 亚洲a成人无m网站在线| 欧美饥渴少妇xxxxx性| 国产后入又长又硬| 99国产欧美久久久精品蜜芽| 国产精品高清一区二区不卡片| 少妇高潮惨叫久久久久电影| 亚洲中文字幕无码乱线| 日韩av高清在线看片| 99久久久国产精品无码免费| 97人洗澡人人澡人人爽人人模| 性中国妓女毛茸茸视频| 一中文字幕日产乱码va| 亚洲爆乳少妇无码激情| 亚洲精品久久区二区三区蜜桃臀| 亚洲欧美日韩国产综合v| 国产午夜成人无码免费| 日本乱码伦午夜福利在线| 丁香五月欧美成人| 精品偷自拍另类在线观看| 亚洲精品一线二线三线区别大吗| 欧美黑人又粗又大的性格特点| 吃奶呻吟打开双腿做受动态图| 精品国产免费一区二区三区香蕉| a在线亚洲男人的天堂| 688欧美人禽杂交狂配| 久久精品www人人爽人人| 免费大黄网站| 果冻传媒mv免费播放在线观看| 国产偷国产偷亚州清高app| 精品黑人一区二区三区久久| 狠狠综合亚洲综合亚洲色|