在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human proenkephalin (PENK) ELISA kit

  • 中文名稱:
    人腦啡肽原(PENK)酶聯免疫試劑盒
  • 貨號:
    CSB-EL017781HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人腦啡肽原(PENK)酶聯免疫試劑盒(CSB-EL017781HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、腦脊液(CSF)樣本中的PENK含量。PENK是一個靶點。它參與內源性阿片肽系統,與疼痛調節、情緒調控等生理過程相關。研究上,主要聚焦其在疾病發生發展中的作用機制,如在神經精神疾病里的功能變化,探索以它為靶點開發新型治療藥物。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,適用于神經生物學研究、精神疾病動物模型評估、疼痛相關分子機制探索等科研領域。尤其適用于腦脊液等低豐度樣本的檢測需求,為神經退行性疾病、藥物成癮或應激相關研究提供可靠的定量數據支持,助力科研人員深入解析 PENK 在復雜生理網絡中的調控作用。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Leu-enkephalin ELISA Kit; Met-enkephalin ELISA Kit; Met-enkephalin-Arg-Gly-Leu ELISA Kit; Met-enkephalin-Arg-Phe ELISA Kit; Methionine enkephalin ELISA Kit; OGF ELISA Kit; Opioid growth factor ELISA Kit; PENK ELISA Kit; PENK(114-133) ELISA Kit; PENK(143-183) ELISA Kit; PENK(237-258) ELISA Kit; PENK_HUMAN ELISA Kit; PPA ELISA Kit; Proenkephalin A ELISA Kit; Proenkephalin ELISA Kit; Proenkephalin-A ELISA Kit; Synenkephalin ELISA Kit
  • 縮寫:
    PENK
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, cerebrospinal fluid (CSF)
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human PENK in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
     SampleSerum(n=4)
    1:1Average %86
    Range %82-92
    1:2Average %97
    Range %91-105
    1:4Average %95
    Range %90-101
    1:8Average %107
    Range %98-112
  • 回收率:
    The recovery of human PENK spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)9387-100
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.302 2.432 2.367 2.263
    5001.762 1.836 1.799 1.695
    2501.114 1.196 1.155 1.051
    1250.653 0.673 0.663 0.559
    61.50.375 0.385 0.380 0.276
    31.20.251 0.271 0.261 0.157
    15.60.151 0.154 0.153 0.049
    00.105 0.103 0.104  
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Increases glutamate release in the striatum and decreases GABA concentration in the striatum.; Increases glutamate release in the striatum.
  • 基因功能參考文獻:
    1. High PENK is associated with increased risk of CKD defined by eGFR in men, but not in women. No association of PENK with CKD defined by urinary albumin excretion UAE was observed. PMID: 29466891
    2. These results demonstrate that proinflammatory molecules and endogenous enkephalin have opposite gene regulation during Dry eye disease. PMID: 29673232
    3. These data indicate that in untrained women exercise training will not change resting of plasma Peptide F concentrations unless both forms of exercise are performed but will result in significant increases in the immediate post-exercise responses. PMID: 28263851
    4. The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD. PMID: 29030229
    5. Peptide F is bound to white blood cells in the blood. Exercise alters Peptide F in the plasma and white blood cell blood fractions. PMID: 23395721
    6. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons. PMID: 26634308
    7. The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions. PMID: 26164485
    8. Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors. PMID: 26218633
    9. BSP demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A, and ppENK in the pancreatic cancer cell line PANC-1. PMID: 25891176
    10. increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage. PMID: 24937654
    11. enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury. PMID: 24937655
    12. EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit PMID: 24496384
    13. Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK. PMID: 23937196
    14. Expression of preproenkephalin is significantly decreased in brain from HIV-1 infected patients compared to HIV-1 negative subjects. PMID: 22391864
    15. The findings suggest an important role for Neuroticism as an endophenotype linking PENK polymorphisms to cannabis-dependence vulnerability synergistically amplifying the apparent genetic risk. PMID: 22745721
    16. found higher levels for MOR mRNA (+27%) in schizophrenia but no differences in DOR or proenkephalin mRNAs PMID: 21810780
    17. Differential tertiary conformations of PE subdomains undergo ordered proteolytic processing to generate active enkephalin peptides for cell-cell communication in the nervous and endocrine systems. PMID: 22102294
    18. we demonstrated reduced ppE expression in patients with elevated psychological distress. PMID: 20628265
    19. indicate alterations of the cerebral PENK A- and PTA-system in both, dementia and acute neuroinflammatory disorders PMID: 20207019
    20. Results suggest that methylation-related inactivation of the ppENK gene is an intermediate or late event during pancreatic carcinogenesis. PMID: 12000709
    21. Proenkephalin peptide F has varying immunoreactivity in different circulatory biocompartments after exercise PMID: 16406203
    22. Proenkephalin A 119-159 is a stable proenkephalin A precursor fragment identified in human circulation PMID: 16621157
    23. The discrete cell-phenotype localization and timing of the changes in the level of PEA and of piGABA-R mRNA. PMID: 17074347
    24. Smoking was not associated with p16 or ppENK hypermethylation in pancreatic cancer patients PMID: 17198183
    25. study provides evidence that the growth-responsive nuclear protein, proenkephalin (Penk), is required, in part, for apoptosis induction, in response to activation or overexpression of p53 and RelA(p65) PMID: 17599100
    26. It found widespread expression of preproenkephalin (pPENK) mRNA and production of the enkephalin precursor protein proenkephalin (PENK) in rat and mouse tissues, as well as in tissues and cells from humans and pigs. PMID: 18082911

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.
  • 蛋白家族:
    Opioid neuropeptide precursor family
  • 數據庫鏈接:

    HGNC: 8831

    OMIM: 131330

    KEGG: hsa:5179

    STRING: 9606.ENSP00000324248

    UniGene: Hs.339831



主站蜘蛛池模板: av片在线观看免费| 亚洲乱码日产一区三区| 欲色影视天天一区二区三区色香欲| 五月丁香综合缴情六月小说| 日本熟妇hdsex视频| 国内少妇高潮嗷嗷叫在线播放| 琪琪午夜伦埋影院77| 欧美牲交a欧美牲交| 玩弄少妇人妻| 日产亚洲一区二区三区| 天堂最新版资源网| 国产av麻豆天堂亚洲国产av刚刚碰| 很黄很色60分钟在线观看| 欧美另类高清zo欧美| 午夜福利理论片在线观看播放| 法国白嫩大屁股xxxx| 亚洲午夜无码极品久久| 丝袜熟女国偷自产中文字幕亚洲| 少妇真人直播免费视频| 久久综合噜噜激激的五月天| 国产 一二三四五六| 中文字幕无码日韩欧免费软件 | 国产精品成人观看视频| 久久久久成人片免费观看蜜芽| 少妇被爽到高潮动态图| 中文幕无线码中文字蜜桃| 国产av成人精品播放| 国产成人a无码短视频 | 亚洲a∨国产av综合av下载| a片在线免费观看| 日本看片一二三区高清| 欧美白人最猛性xxxxx| 欧美三级a做爰在线观看| 精品福利视频一区二区三区| 波多野结衣av在线无码中文18| 日本xxxx丰满老妇| 中文字幕一精品亚洲无线一区| 久久久亚洲欧洲日产国码农村| 97久久超碰国产精品最新| 人妻少妇无码专视频在线| 国产精品对白刺激久久久|