在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human proenkephalin (PENK) ELISA kit

  • 中文名稱:
    人腦啡肽原(PENK)酶聯免疫試劑盒
  • 貨號:
    CSB-EL017781HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人腦啡肽原(PENK)酶聯免疫試劑盒(CSB-EL017781HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、腦脊液(CSF)樣本中的PENK含量。PENK是一個靶點。它參與內源性阿片肽系統,與疼痛調節、情緒調控等生理過程相關。研究上,主要聚焦其在疾病發生發展中的作用機制,如在神經精神疾病里的功能變化,探索以它為靶點開發新型治療藥物。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,適用于神經生物學研究、精神疾病動物模型評估、疼痛相關分子機制探索等科研領域。尤其適用于腦脊液等低豐度樣本的檢測需求,為神經退行性疾病、藥物成癮或應激相關研究提供可靠的定量數據支持,助力科研人員深入解析 PENK 在復雜生理網絡中的調控作用。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Leu-enkephalin ELISA Kit; Met-enkephalin ELISA Kit; Met-enkephalin-Arg-Gly-Leu ELISA Kit; Met-enkephalin-Arg-Phe ELISA Kit; Methionine enkephalin ELISA Kit; OGF ELISA Kit; Opioid growth factor ELISA Kit; PENK ELISA Kit; PENK(114-133) ELISA Kit; PENK(143-183) ELISA Kit; PENK(237-258) ELISA Kit; PENK_HUMAN ELISA Kit; PPA ELISA Kit; Proenkephalin A ELISA Kit; Proenkephalin ELISA Kit; Proenkephalin-A ELISA Kit; Synenkephalin ELISA Kit
  • 縮寫:
    PENK
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, cerebrospinal fluid (CSF)
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human PENK in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
     SampleSerum(n=4)
    1:1Average %86
    Range %82-92
    1:2Average %97
    Range %91-105
    1:4Average %95
    Range %90-101
    1:8Average %107
    Range %98-112
  • 回收率:
    The recovery of human PENK spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)9387-100
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.302 2.432 2.367 2.263
    5001.762 1.836 1.799 1.695
    2501.114 1.196 1.155 1.051
    1250.653 0.673 0.663 0.559
    61.50.375 0.385 0.380 0.276
    31.20.251 0.271 0.261 0.157
    15.60.151 0.154 0.153 0.049
    00.105 0.103 0.104  
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Increases glutamate release in the striatum and decreases GABA concentration in the striatum.; Increases glutamate release in the striatum.
  • 基因功能參考文獻:
    1. High PENK is associated with increased risk of CKD defined by eGFR in men, but not in women. No association of PENK with CKD defined by urinary albumin excretion UAE was observed. PMID: 29466891
    2. These results demonstrate that proinflammatory molecules and endogenous enkephalin have opposite gene regulation during Dry eye disease. PMID: 29673232
    3. These data indicate that in untrained women exercise training will not change resting of plasma Peptide F concentrations unless both forms of exercise are performed but will result in significant increases in the immediate post-exercise responses. PMID: 28263851
    4. The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD. PMID: 29030229
    5. Peptide F is bound to white blood cells in the blood. Exercise alters Peptide F in the plasma and white blood cell blood fractions. PMID: 23395721
    6. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons. PMID: 26634308
    7. The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions. PMID: 26164485
    8. Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors. PMID: 26218633
    9. BSP demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A, and ppENK in the pancreatic cancer cell line PANC-1. PMID: 25891176
    10. increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage. PMID: 24937654
    11. enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury. PMID: 24937655
    12. EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit PMID: 24496384
    13. Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK. PMID: 23937196
    14. Expression of preproenkephalin is significantly decreased in brain from HIV-1 infected patients compared to HIV-1 negative subjects. PMID: 22391864
    15. The findings suggest an important role for Neuroticism as an endophenotype linking PENK polymorphisms to cannabis-dependence vulnerability synergistically amplifying the apparent genetic risk. PMID: 22745721
    16. found higher levels for MOR mRNA (+27%) in schizophrenia but no differences in DOR or proenkephalin mRNAs PMID: 21810780
    17. Differential tertiary conformations of PE subdomains undergo ordered proteolytic processing to generate active enkephalin peptides for cell-cell communication in the nervous and endocrine systems. PMID: 22102294
    18. we demonstrated reduced ppE expression in patients with elevated psychological distress. PMID: 20628265
    19. indicate alterations of the cerebral PENK A- and PTA-system in both, dementia and acute neuroinflammatory disorders PMID: 20207019
    20. Results suggest that methylation-related inactivation of the ppENK gene is an intermediate or late event during pancreatic carcinogenesis. PMID: 12000709
    21. Proenkephalin peptide F has varying immunoreactivity in different circulatory biocompartments after exercise PMID: 16406203
    22. Proenkephalin A 119-159 is a stable proenkephalin A precursor fragment identified in human circulation PMID: 16621157
    23. The discrete cell-phenotype localization and timing of the changes in the level of PEA and of piGABA-R mRNA. PMID: 17074347
    24. Smoking was not associated with p16 or ppENK hypermethylation in pancreatic cancer patients PMID: 17198183
    25. study provides evidence that the growth-responsive nuclear protein, proenkephalin (Penk), is required, in part, for apoptosis induction, in response to activation or overexpression of p53 and RelA(p65) PMID: 17599100
    26. It found widespread expression of preproenkephalin (pPENK) mRNA and production of the enkephalin precursor protein proenkephalin (PENK) in rat and mouse tissues, as well as in tissues and cells from humans and pigs. PMID: 18082911

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.
  • 蛋白家族:
    Opioid neuropeptide precursor family
  • 數據庫鏈接:

    HGNC: 8831

    OMIM: 131330

    KEGG: hsa:5179

    STRING: 9606.ENSP00000324248

    UniGene: Hs.339831



主站蜘蛛池模板: 香港台湾经典三级a视频| 久久综合伊人中文字幕| 肉色欧美久久久久久久免费看 | 人妻少妇精品无码专区动漫| 噜噜色综合噜噜色噜噜色| 永久免费的啪啪网站免费观看| 又爽又色禁片1000视频免费看| 无码精品a∨在线观看十八禁| 国产尤物精品自在拍视频首页| 久久久久亚洲精品中文字幕| 亚洲乱码精品久久久久..| 久久精品国产99国产精2020丨| 亚洲国产成人超a在线播放| 狠狠亚洲狠狠欧洲2019| 亚洲永久无码7777kkk| 日本不卡一区二区三区在线| 久久久久亚洲精品天堂| 男女做爰猛烈叫床视频动态图| 国产卡一卡二卡三| 亚洲永久网址在线观看| 六月丁香综合在线视频| 亚洲腹肌男啪啪网站男同| 欧美黑人又粗又大久久久| 鲁大师影院在线观看| 人妻夜夜爽天天爽| 55夜色66夜色国产精品视频| 亚洲毛片多多影院| 免费观看羞羞视频网站| 国产又黄又爽又色的免费| 熟女人妻高清一区二区三区| 亚洲精品一区二三区不卡| 精品乱码一区二区三区四区| 国产99久久亚洲综合精品西瓜tv| 麻豆国产丝袜白领秘书在线观看| 狠狠色噜噜狠狠狠888米奇| 国产成人无码18禁午夜福利p| 9420免费高清在线观看视频| 亚洲精品无码mv在线观看网站| 欧美亚洲精品一区二区| 影音先锋女人aa鲁色资源| 久久婷婷综合激情亚洲狠狠|