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  4. Human pregnancy associated plasma protein A,PAPP-A ELISA Kit

Human pregnancy associated plasma protein A,PAPP-A ELISA Kit

  • 中文名稱：
    人妊娠相關血漿蛋白A(PAPP-A)酶聯免疫試劑盒
  • 貨號：
    CSB-E08220h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人妊娠相關血漿蛋白A(PAPP-A)酶聯免疫試劑盒（CSB-E08220h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液樣本中的PAPPA含量。PAPPA即妊娠相關血漿蛋白A，在心血管疾病、腫瘤等領域有重要作用。其背景為可作為一些疾病生物標志物。研究機制上，PAPPA可裂解胰島素樣生長因子結合蛋白，調節胰島素樣生長因子活性，進而影響細胞增殖、遷移等生物學過程。試劑盒檢測范圍為1.7 ng/mL-50 ng/mL，適用于體外分析不同生理或病理條件下PAPP - A的表達動態，可支持生殖醫學、胎盤功能機制研究、妊娠相關疾病模型評估等科研項目，同時也可用于探索PAPP - A在心血管疾病、腫瘤微環境等跨學科領域中的潛在生物學功能本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    ASBABP2 ELISA Kit; Aspecific BCL2 ARE binding protein 2 ELISA Kit; Differentially placenta 1 expressed protein ELISA Kit; DIPLA1 ELISA Kit; EC 3.4.24.79 ELISA Kit; IGF dependent IGFBP 4 protease ELISA Kit; IGF-dependent IGFBP-4 protease ELISA Kit; IGFBP 4ase ELISA Kit; IGFBP-4ase ELISA Kit; IGFBP4ase ELISA Kit; Insulin like growth factor dependent IGF binding protein 4 protease ELISA Kit; Insulin-like growth factor-dependent IGF-binding protein 4 protease ELISA Kit; PAPA ELISA Kit; PAPP A ELISA Kit; PAPP-A ELISA Kit; PAPP1_HUMAN ELISA Kit; PAPPA ELISA Kit; PAPPA1 ELISA Kit; Pappalysin 1 precursor ELISA Kit; Pappalysin-1 ELISA Kit; Pregnancy Associated Plasma Protein A ELISA Kit; Pregnancy associated plasma protein A pappalysin 1 ELISA Kit; Pregnancy-associated plasma protein A ELISA Kit
  • 縮寫：
    PAPPA
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, urine
  • 檢測范圍：
    1.7 ng/mL-50 ng/mL
  • 靈敏度：
    0.4 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<15%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human PAPP-A in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:5 Average % 86  
    Range % 80-93  
    1:10 Average % 90  
    Range % 85-95  
    1:20 Average % 95  
    Range % 90-100  
    1:40 Average % 94  
    Range % 86-100  
  • 回收率：
    The recovery of human PAPP-A spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 95 89-98  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    50 2.542 2.452 2.497 2.450  
    20.8 1.283 1.356 1.320 1.273  
    8.3 0.642 0.631 0.637 0.590  
    3.3 0.287 0.305 0.296 0.249  
    1.7 0.155 0.160 0.158 0.111  
    0 0.046 0.047 0.047 　  
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
  • 基因功能參考文獻：
    1. Serum PAPP-A at third trimester of pregnancy was not associated with late-onset pre-eclampsia and intrauterine growth retardation after 34weeks of pregnancy. PMID: 29674192
    2. Elevated PROK1 in the first pregnancy trimester is a more effective marker than PAPP-A in the prediction of pre-eclampsia and fetal growth restriction. PMID: 28675948
    3. The findings suggest a possible pathophysiological link between the development of Fetal growth restriction and the expression of PAPPA, PAPPA2 and PLAC-1. PMID: 29532882
    4. Data suggest that PGF and PAPPA serve as serum biomarkers for early diagnosis of gestational hypertension. These studies were conducted at antenatal clinics in Ghana using blood from women between 8 and 13 weeks gestation. (PGF = placental growth factor; PAPPA = pregnancy-associated plasma protein-A) PMID: 29587776
    5. Pregnancy associated plasma protein-A (PAPP-A) appears to be a potentially useful biomarker for short-term risk stratification of patients presenting with chest pain of ischemic origin (Review). PMID: 29144175
    6. These data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of Preeclampsia. Bioinformatics analysis predicted that hsa_circ_0004904 and hsa_circ_0001855 miRNA sponges directly target PAPP-A. PMID: 29758559
    7. higher first trimester serum values seem to be associated with placenta accreta in women with placenta previa PMID: 28027672
    8. Studied the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease. PMID: 27809366
    9. maternal serum levels associated with small for gestational age neonates, preterm birth, and pre-eclampsia PMID: 28514830
    10. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients. PMID: 28537443
    11. low levels not associated with high serum estradiol at controlled ovarian stimulation PMID: 28606451
    12. PAPP-A C/C genotypes were more frequent among mothers with gestational diabetes than in control. PMID: 28655969
    13. Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with type 2 diabetes mellitus. PMID: 28381225
    14. PAPP-A, like CCS and CIMT, is a parameter that can be used to detect subclinical atherosclerosis. PMID: 28791822
    15. Results suggest that links between PAPP-A concentrations in early pregnancy and subsequent glucose concentrations and blood pressures may be mediated by changes in insulin sensitivity (and secretion). PMID: 28323969
    16. Collectively, these results identify PAPP-A as a pregnancy-dependent oncogene while also showing that extended lactation is protective against PAPP-A-mediated carcinogenesis. PMID: 26951623
    17. Lower PlGF and higher PAPP-A and free beta-hCG levels were found in the fetal circulation of near-term severe preeclamptic pregnancies PMID: 27809614
    18. PAPP-A 1224 SNP has a significant effect on the level and activity of PAPP-A in human follicles, suggesting that the follicular fluid level of bioactive insulin-like growth factor depends on the genotype. PMID: 27793387
    19. This study demonstrated no association between PAPP-A gene rs7020782 polymorphism and Preeclampsia (PE) and intrauterine growth restriction. PMID: 26520690
    20. data indicate that PAPP-A promotes TF expression in human endothelial cells and support the hypothesis that this proteinase, besides being involved in progression of atherosclerosis, does not represent an independent risk factor for adverse cardiovascular events, but it rather might play an "active" role in the pathophysiology of ACS as an effector molecule able to induce a pro-thrombotic phenotype in endothelial cells PMID: 27007282
    21. assessed serum PAPP-A levels in COPD and the associations with disease severity; elevated levels of PAPP-A were observed in patients with COPD PMID: 27090654
    22. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    23. Data suggest that stanniocalcin 1 and 2 (STC1, STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis. PMID: 26874357
    24. measurements of maternal serum PAPP-A concentration in the first trimester predict severe fetal growth restriction more effectively than they predict a birth weight below the 10th percentile among a Chinese population PMID: 25845987
    25. Women with PAPP-A /=90th percentile is protective against small for gestational age, and is associated with an increased risk of large for gestational age for infants born after 32 weeks gestation. PMID: 26773241
    26. Data suggest that incidences of intrauterine growth restriction, pre-eclampsia, preterm birth, and fetal death are significantly greater in pregnant women with low serum levels of PAPP-A in first trimester (9-13 weeks of pregnancy) as compared to control pregnant women; study was conducted in India. PMID: 25773764
    27. The first trimester maternal PAPP-A levels were decreased in the ICSI group compared with those in the controls, but not in IVF and embryo transfer groups. PMID: 26697810
    28. miR-141 may play important roles in ox-LDL-induced abnormal proliferation of the vascular smooth muscle cells by targeting PAPPA. PMID: 26823756
    29. Combined analysis of PAPP-A and free beta-hCG appears to be a potential candidate to predict early fetal loss. PMID: 25159705
    30. PAPP-A in ascites and tissue-associated PAPP-A serve to increase IGF bioactivity and, thereby, to stimulate IGF-IR-mediated ovarian tumor growth. PMID: 26336825
    31. PAPP-A determination during the first trimester of pregnancy in women at risk for IUGR makes possible the prophylactic treatment and monitoring of pregnancy. PMID: 27125092
    32. Data indicate that rising pregnancy-associated plasma protein-A (PAPP-A) levels are prognostic in patients with coronary artery disease (CAD). PMID: 26223809
    33. PAPP-A serum concentrations differed significantly between Asian and European women during the first trimester of pregnancy. PMID: 25858516
    34. The study findings showed that plasma sCD40L, fetuin-A, and PAPP-A levels are associated with carotid plaque formation and instability. PMID: 26214492
    35. For Down syndrome affected pregnancies, the median MoM of first trimester PAPP-A, PlGF, and AFP were significantly reduced, and free-beta-hCG were significantly elevated. PMID: 25846403
    36. Increased PAPP-A in the first trimester is associated with placenta accreta. PMID: 24226752
    37. Maternal serum PAPP-A was not associated with fetal open spina bifida. PMID: 24226839
    38. The A>C variation of rs7020782 of PAPPA might be an independent risk factor for carotid plaque development and calcification. PMID: 26122709
    39. Elevated PAPP-A was associated with fetal macrosomia. PMID: 24155168
    40. Suggest that PAPP-A is specifically involved in the regulation of steroidogenesis in human antral follicles. PMID: 26297643
    41. The performance of screening for GDM by maternal factors was not improved by the addition of PAPP-A and/or PLGF. First trimester maternal serum PAPP-A and PLGF are not useful in screening for GDM. PMID: 26362726
    42. serum variations during the first trimester cannot be used as a marker of excessive fetal growth PMID: 24940710
    43. Data suggest both serum PAPP-A and serum CRP (high-sensitivity C-reactive protein) are up-regulated during first trimester in women who will undergo early pregnancy failure. PMID: 25596909
    44. PAPPA was similar between pregnant women with chronic kidney disease and controls. PMID: 25395363
    45. Median PAPP-A MoM was 1.01 in the control group and 1.05 (P = 0.83) in praevia, compared with 1.22 in abnormally invasive placentation cases (0.16). PMID: 25639820
    46. A PAPP-A value, expressed in MoM, of 1.25 is a predictive factor of fetal birth weight >4000 g PMID: 24743523
    47. first trimester PAPP-A levels were measured to see if they were associated with negative pregnancy outcome. Groups with high and low PAPP-A significantly differed only in miscarriages. PMID: 25139218
    48. inadequate sensitivity as first trimester serum marker for pre-eclampsia PMID: 24786703
    49. Serum PAPP-A levels were closely associated with the coronary no-reflow phenomenon during percutaneous coronary intervention. PMID: 24227626
    50. High PAPP-A expression is associated with breast cancer. PMID: 25468445

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M43B family
  • 組織特異性：
    High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium
  • 數據庫鏈接：

    HGNC: 8602

    OMIM: 176385

    KEGG: hsa:5069

    STRING: 9606.ENSP00000330658

    UniGene: Hs.643599



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