在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human orphanin FQ/nociceptin,OFQ/N ELISA Kit

Human orphanin FQ/nociceptin,OFQ/N ELISA Kit

  • 中文名稱：
    人孤腓肽(OFQ/N)酶聯免疫試劑盒
  • 貨號：
    CSB-E09741h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人孤腓肽(OFQ/N)酶聯免疫試劑盒（CSB-E09741h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液樣本中的PNOC含量。PNOC是一種靶點。它可能參與體內多種生理過程，其相關研究機制或是從神經調節、內分泌等方面入手。通過對PNOC進行深入研究，有望在神經、內分泌等相關疾病的治療上挖掘新的藥物靶點，為開發新療法提供理論依據。試劑盒檢測范圍為4.69 pg/mL-300 pg/mL，適用于神經生物學、藥理學等領域的基礎研究，例如探索疼痛機制、精神疾病模型中的肽類表達變化，或評估細胞實驗中OFQ/N的分泌動態。通過可靠的定量結果，為科研人員解析OFQ/N在生理及病理過程中的調控作用提供有力工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    N/OFQ ELISA Kit; N23K ELISA Kit; N23K/N27K ELISA Kit; Nociceptin, included ELISA Kit; nocistatin ELISA Kit; Npnc1 ELISA Kit; OFQ ELISA Kit; OFQ/N ELISA Kit; Orphanin FQ ELISA Kit; Orphanin FQ2 ELISA Kit; Pnoc ELISA Kit; PNOC_HUMAN ELISA Kit; ppN/OFQ ELISA Kit; PPNOC ELISA Kit; pre-pro-N/OFQ ELISA Kit; prepronociceptin ELISA Kit; pronociceptin ELISA Kit; Propronociceptin ELISA Kit
  • 縮寫：
    OFQ/N
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates
  • 檢測范圍：
    4.69 pg/mL-300 pg/mL
  • 靈敏度：
    1.17 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human OFQ/N in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 91  
    Range % 80-105  
    1:2 Average % 96  
    Range % 85-114  
    1:4 Average % 93  
    Range % 92-114  
    1:8 Average % 95  
    Range % 80-110  
  • 回收率：
    The recovery of human OFQ/N spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 93 80-110  
    EDTA plasma (n=4) 95 90-102  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    300 2.614 2.621 2.618 2.475  
    150 1.882 1.887 1.885 1.742  
    75 1.325 1.330 1.328 1.185  
    37.5 0.771 0.774 0.773 0.630  
    18.75 0.439 0.441 0.440 0.297  
    9.38 0.268 0.284 0.276 0.133  
    4.69 0.236 0.252 0.244 0.101  
    0 0.138 0.148 0.143 　  
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.; Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.; Has potent analgesic activity.
  • 基因功能參考文獻：
    1. found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC and COMT SNP genotype. PMID: 27983768
    2. The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants. PMID: 26791055
    3. Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW] PMID: 25677772
    4. Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW] PMID: 25677774
    5. REVIEW: intracellular localization and physiological role of nociceptin and nocistatin PMID: 23454174
    6. Strong expression of PNOC was seen in neoplastic neurons of 7/7 brainstem gangliogliomas, but was significantly weaker in non-brainstem GGs. PMID: 22706982
    7. The presence of Orphanin, Oxytocin, ANP, eNOS and iNOS proteins was identified in the human umbilical cord.[Orphanin] PMID: 21744319
    8. A high expression of nociceptin in adenomyosis may be one of the casual factors of dysmenorrhea. The severity of dysmenorrhea is positively correlated with the expression of nociceptin in eutopic endometrial tissue. PMID: 21600132
    9. chronic ischemic conditions of atherosclerotic origin are associated with significantly lower plasma nociceptin levels PMID: 21310194
    10. PNOC expression level was 2.99 times higher in vitiligo involved skin when compared to healthy control skin. PMID: 20888736
    11. Results showed that vigorous and prolonged hyperventilation changes plasma nociceptin/orphanin FQ levels due to the direct effects of hypocapnic alkalosis or to different sympatho-adrenergic system responses. PMID: 20100531
    12. Peripheral blood levels are elevated in Wilson disease PMID: 12812047
    13. results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues PMID: 12950177
    14. The presence of two different forms of mature nocistatin (NST-17 and NST-30) and a possible N-terminal methionine cleaved NST-29 have been confirmed by both radioimmunoassay and mass spectrometry. PMID: 16043263
    15. Two SNPs in PNOC showed marginal association with alcoholism and one with illicit drug dependence. PMID: 17910740
    16. Peripheral blood mononuclear cells transcribe pre-pro-nociception/orphaninFQ. PMID: 18292431
    17. Unstable angina is associated with a significant increase in circulating nociceptin/orphanin FQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. PMID: 19560501

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Opioid neuropeptide precursor family
  • 組織特異性：
    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • 數據庫鏈接：

    HGNC: 9163

    OMIM: 601459

    KEGG: hsa:5368

    STRING: 9606.ENSP00000301908

    UniGene: Hs.88218



主站蜘蛛池模板： 亚洲精品无码国产| 爆爽久久久一区二区又大又黄又嫩 | 无码人妻斩一区二区三区| 中文字幕亚洲综合久久菠萝蜜| 久久人人爽人人爽人人片亞洲| 日本丰满护士bbw| 久久久99精品成人片| 99在线精品国自产拍| 婷婷四房播播| 亚洲国产精品无码中文字满| 国产亚洲精品一区在线播放| 无码人妻久久一区二区三区app| 一本久久知道综合久久| 亚洲va久久久噜噜噜久久狠狠| 超碰cao已满18进入离开官网| 国产亚洲精品久久久久久禁果tv | 国产精品久久久久9999爆乳| 日本最新免费二区| 国产在线观看免费观看不卡| 亚洲色国产欧美日韩| 免费无遮挡无码永久在线观看视频| 少妇无套内谢久久久久| 国产成人美女裸体片免费看| 久久国产加勒比精品无码| 久久大香香蕉国产| 久久亚洲精品国产亚洲老地址| 日韩人妻潮喷中文在线视频| 在线播放国产精品三级| 动漫精品啪啪一区二区三区| 欧美成va视频网站| 亚洲不卡一卡2卡三卡4卡5卡| 国产香蕉97碰碰久久人人| av午夜久久蜜桃传媒软件| 呻吟国产av久久一区二区| 又爽又黄又无遮挡的激情视频| 人人妻人人澡人人爽秒播| 久久人妻无码中文字幕| 久久人妻国产精品| 可以免费观看的av毛片下载| 亚洲 自拍 另类 欧美 综合| 新国产精品视频福利免费|