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  4. Human orosomucoid 2,ORM2 ELISA Kit

Human orosomucoid 2,ORM2 ELISA Kit

  • 中文名稱：
    人類粘蛋白2(ORM2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E11821h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人類粘蛋白2(ORM2)酶聯(lián)免疫試劑盒（CSB-E11821h）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ORM2含量。試劑盒檢測范圍為78 ng/mL-5000 ng/mL，靈敏度為19.5 ng/mL。適用于科研領(lǐng)域中對ORM2蛋白表達(dá)水平的定量分析，例如探索炎癥相關(guān)疾病機(jī)制、評估代謝綜合征生物標(biāo)志物或研究肝臟功能異常模型中的蛋白動(dòng)態(tài)變化本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ORM2 ELISA Kit; AGP2Alpha-1-acid glycoprotein 2 ELISA Kit; AGP 2 ELISA Kit; Orosomucoid-2 ELISA Kit; OMD 2 ELISA Kit
  • 縮寫：
    ORM2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 ng/mL-5000 ng/mL
  • 靈敏度：
    19.5 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ORM2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:100 Average % 98  
    Range % 90-102  
    1:200 Average % 89  
    Range % 83-94  
    1:400 Average % 101  
    Range % 93-105  
    1:800 Average % 105  
    Range % 97-110  
  • 回收率：
    The recovery of human ORM2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 90 82-95  
    EDTA plasma (n=4) 94 90-98  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average    
    5000 0.131 0.135 0.133    
    2500 0.389 0.401 0.395    
    1250 0.750 0.732 0.741    
    625 1.042 1.020 1.031    
    312 1.441 1.454 1.448    
    156 1.650 1.666 1.658    
    78 1.806 1.767 1.787    
    0 2.001 2.078 2.040    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    ORM2，全稱為酸性糖蛋白，是一種血漿蛋白。最近的研究表明，ORM2在多種疾病中發(fā)揮著重要作用，包括炎癥、心血管疾病和肝病等。ORM2參與了細(xì)胞凋亡、免疫反應(yīng)和糖代謝等生物學(xué)過程。
  • 功能：
    Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
  • 基因功能參考文獻(xiàn)：
    1. the glycosylation change of alpha-1-acid glycoprotein (AGP) in hepatocellular carcinoma (HCC), cirrhosis and controls PMID: 28621608
    2. Neural cell interactions are important for brain physiology and pathology. Particularly, the interaction between non-neuronal cells plays a central role in regulating brain inflammation, which is closely linked to many brain disorders. Here, we newly identified orosomucoid-2 (ORM2) as an endogenous protein that mediates such non-neuronal glial cell interactions PMID: 28193696
    3. Low ORM2 expression is associated with metastasis in hepatocellular carcinoma. PMID: 25965830
    4. Data suggest that human serum albumin (HSA) might serve as a carrier in delivering chitooligomers to target tissues than alpha-1-glycoprotein (AGP) which has pharmacological importance. PMID: 24359035
    5. Alteration in expression of ORM2 suggests that ORM2 could be used as a potential biomarker in the diagnosis of colorectal cancer. PMID: 22363757
    6. the sera of patients with acute inflammation demonstrated increased numbers of bi-antennary and alpha1,3-fucosylated N-glycan structures at each glycosylation site PMID: 15863355
    7. The binding of coumarin enantiomers to ORM2 is studied. PMID: 16290938
    8. Results describe the thermal unfolding and reversibility of temperature-induced changes in alpha(1)-acid glycoprotein. PMID: 16331959
    9. The results indicate that, in accordance with prior expectations, the ORM2 variant is responsible for the acute-phase property of alpha-1 acid glycoprotein. PMID: 19018521
    10. structure of the alpha1-acid glycoprotein (AGP), or orosomucoid (ORM), gene was investigated in a Ghanaian mother and her child, who shared an unusual variant, ORM1 S2(C), found by isoelectric focusing PMID: 11587070

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8499

    OMIM: 138610

    KEGG: hsa:5005

    STRING: 9606.ENSP00000394936

    UniGene: Hs.719954



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