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Human microalbunminuria(MAU/ALB) ELISA kit

  • 中文名稱:
    人尿微量白蛋白(MAU/ALB)酶聯免疫試劑盒
  • 貨號:
    CSB-E08970h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人尿微量白蛋白(MAU/ALB)酶聯免疫試劑盒(CSB-E08970h)為競爭法ELISA試劑盒,定量檢測血清、血漿、尿液樣本中的MAU/ALB含量。MAU/ALB即尿微量白蛋白與尿肌酐比值,是反映早期腎損傷的敏感指標。研究機制主要是通過檢測其水平變化,評估腎臟濾過功能和血管內皮損傷情況。在糖尿病、高血壓等疾病引發的腎損傷早期,MAU/ALB就可能出現異常,助于早干預。試劑盒檢測范圍為0.078 μg/mL-5 μg/mL,靈敏度為0.019 μg/mL。該產品可廣泛應用于基礎醫學研究領域,如腎臟病理模型構建、藥物腎毒性評估、糖尿病腎病機制探索等方向,其多樣本兼容特性支持科研人員根據實驗需求靈活選擇生物體液類型進行檢測分析,為生理及病理狀態下蛋白質代謝研究提供可靠數據支持。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    alb ELISA Kit; ALBU_HUMAN ELISA Kit; Albumin (32 AA) ELISA Kit; Albumin (AA 34) ELISA Kit; cell growth inhibiting protein 42 ELISA Kit; DKFZp779N1935 ELISA Kit; GIG20 ELISA Kit; GIG42 ELISA Kit; Growth inhibiting protein 20 ELISA Kit; growth-inhibiting protein 20 ELISA Kit; OTTHUMP00000220436 ELISA Kit; OTTHUMP00000220438 ELISA Kit; OTTHUMP00000220439 ELISA Kit; PRO0883 ELISA Kit; PRO0903 ELISA Kit; PRO1341 ELISA Kit; PRO1708 ELISA Kit; PRO2044 ELISA Kit; PRO2619 ELISA Kit; PRO2675 ELISA Kit; Serum albumin ELISA Kit; UNQ696/PRO1341 ELISA Kit
  • 縮寫:
    MAU/ALB
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, urine
  • 檢測范圍:
    0.078 μg/mL-5 μg/mL
  • 靈敏度:
    0.019 μg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Metabolism
  • 測定原理:
    quantitative
  • 測定方法:
    Competitive
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human MAU in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:10000 Average % 90  
    Range % 83-103  
    1:20000 Average % 92  
    Range % 89-97  
    1:40000 Average % 96  
    Range % 89-105  
    1:80000 Average % 95  
    Range % 86-104  
  • 回收率:
    The recovery of human MAU spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 97 89-108  
    EDTA plasma (n=4) 94 86-100  
                 
                 
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    μg/ml OD1 OD2 Average    
    5 0.155 0.167 0.161    
    2.5 0.304 0.299 0.302    
    1.25 0.448 0.459 0.454    
    0.625 0.730 0.794 0.762    
    0.312 1.212 1.228 1.220    
    0.156 1.733 1.701 1.717    
    0.078 1.993 2.006 2.000    
    0 2.501 2.529 2.515    
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

相關問答

 常見問題解答
Q:

Can it detect albumin?

A:
Thanks for your inquiry. Yes it can detect albumin.
Q:

We currently use your HSA ELISA kit and I was wondering if you could advise as to whether any of the constituent reagents contain Sodium Azide (NAN3).

A:
Thanks for your inquiry.
There is no constituent reagents containing Sodium Azide (NAN3) in our kit.

靶點詳情

  • 最新研究進展:
        AMBP(α1-酸性糖蛋白)是一種糖蛋白,主要存在于血漿中。最新的研究表明,AMBP在許多生理和病理過程中發揮著重要作用,包括免疫反應、腫瘤發生和心血管疾病等。研究者們正在努力探索AMBP的作用機制,以期為相關疾病的治療提供新的思路和方法。
  • 功能:
    Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
  • 基因功能參考文獻:
    1. relatively low serum concentrations of albumin may be an independent risk factor for Mild cognitive impairment in elderly. PMID: 30249938
    2. Albumin-globulin ratio in combination with CEA provides a more accurate indicator of poor prognosis and early recurrence in rectal carcinoma patients treated with preoperative chemoradiotherapy. PMID: 29996133
    3. Patients with steroid-refractory GI Acute graft versus host disease had higher fecal calprotectin levels and lower albumin levels than patients with steroid-responsive disease. PMID: 29397331
    4. Lower serum albumin concentrations in patients with pulmonary arterial hypertension are associated with higher mortality and can serve as a marker of disease severity in this patient population. PMID: 29604093
    5. This meta-analysis suggests that C-reactive protein/albumin ratio (CAR)may be a potential prognostic marker in solid cancers PMID: 28128229
    6. Thiol/Disuldife homeostasis balance and ischemia-modified albumin levels may be used a biomarker to monitor the tissue ischemia in diabetic mellitus and to discriminate the different stages of diabetic retinopathy. PMID: 29298534
    7. mitochondrial dysfunction activates the PINK1/Parkin signaling and mitophagy in renal tubular epithelial cells under albumin overload condition. PMID: 29494565
    8. Serum ischemia-modified albumin (IMA) in addition to the prevalence of small for gestational age (SGA) were significantly increased in the pre-eclampsia group. Cord blood IMA, therefore, might be a predictive biomarker for SGA in pre-eclampsia pregnancies. PMID: 29570915
    9. By using the fluorescence activatable nanosensor as the structural indicator, the stepwise conformational transitions of HSA during denaturing and the partial refolding of subdomain IIA of HSA were facilely visualized. PMID: 27232658
    10. Serum albumin adduct features were both positively and negatively associated with smoking, indicating that some adducts arise from reactions between Cys34 and constituents of cigarette smoke (e.g., ethylene oxide and acrylonitrile) while others (Cys34 oxidation products and disulfides) appear to reflect alterations in the serum redox state that resulted in reduced adduct levels in smokers. PMID: 27684351
    11. the increased lipophilicity of sulphur-containing compounds might be a reason for their better binding to HSA. PMID: 29128746
    12. hese obtained results provide an in-depth understanding of the interaction of the acid azo dye AO10 with serum albumins. PMID: 29126006
    13. A higher preoperative serum ALB level is associated with better long-term survival in intrahepatic cholangiocarcinoma patients. PMID: 29672305
    14. the presence of hydroxyl groups is capable of modulating the interaction between riparins and HSA. PMID: 28915468
    15. Spectroscopic and molecular docking studies on the interaction of human serum albumin with copper(II) complexes. PMID: 27792986
    16. aberrant HSA may play a role in the initiation/progression of type 1 diabetes mellitus. PMID: 29051099
    17. Results show that albumin from chronic hemodialyzed (CH) patients is highly modified in vivo and is not vulnerable to oxidation in the same way as normal albumin. PMID: 29554100
    18. These results indicate that low serum albumin levels correlate with increased parameter measures of hepatocellular carcinoma (HCC) aggressiveness, in addition to their role as a monitor of systemic inflammation. Decreased serum albumin might have a role in HCC aggressiveness. PMID: 28862714
    19. The hypothesis put forward that human serum albumin is a modulator and transporter of cannabinoid drugs. PMID: 28976704
    20. CRP/albumin ratio is a novel but promising, easy-to-measure, repeatable, non-invasive inflammation-based prognostic score in acute pancreatitis. PMID: 28823374
    21. homodimerization is a novel described structural alteration of the HA molecule in decompensated cirrhosis and contributes to the progressive reduction of the monomeric native HA, the only isoform provided of structural and functional integrity PMID: 27782157
    22. Low serum albumin concentration worsens prognosis of patients with stable coronary heart disease. PMID: 28413113
    23. Human serum albumin binds to Cu(I) at pH 7.4 with an apparent conditional affinity of KCu(I):serum albumin = 10(14.0) using digonal coordination in a structure that is similar to the bis-His coordination modes characterized for amyloid beta (Abeta) and the prion protein. PMID: 29166002
    24. C-reactive protein/albumin ratio (CAR), an inflammation-based prognostic score, is a potential independent predictor for disease progression and death in patients with operable non-small cell lung cancer. PMID: 27823974
    25. these peptides are identified as fragments of albumin. The isolated fragments activate MRGPRX2 and degranulate MRGPRX2 expressing LAD 2 cells in dose-dependent manner. The isolated basic peptides generated from human albumin are able to degranulate mast cells via the MRGPRX2. PMID: 28844982
    26. use of EPI-X4, a fragment of serum albumin, as a urinary biomarker for late acute GvHD was shown to be not meaningful in case control studies PMID: 27042833
    27. serum ALB level may be more useful than the degree of fibrosis for the prediction of hepatocellular carcinoma after sustained virological responses in chronic hepatitis C. PMID: 29040987
    28. Increased Ischemia-modified albumin levels and Carotid intima-media thickness may be related to increased oxidative stress and risk of atherosclerosis in individuals with Obstructive sleep apnea. PMID: 27029471
    29. Peak unbound bilirubin was primarily associated with a decrease in bilirubin albumin binding affinity in infants PMID: 29132818
    30. This meta-analysis showing increased ischaemia-modified albumin (IMA) level in both hypothyroidism and hyperthyroidism patients and its association with thyroid profile suggests that serum IMA could be used as a simple measure of increased oxidative stress in thyroid dysfunction. PMID: 27920278
    31. The optimal cut-off value was identified to be 45.6 g/L, 26.9 g/L and 1.30 for serum albumin (ALB), serum globulin (GLB) and albumin/globulin ratio (AGR) in terms of survival, respectively. PMID: 27105522
    32. Physiological serum copper concentrations found in malignancies cause unfolding induced aggregation of human serum albumin in vitro. PMID: 29122590
    33. the structural homology between HSA and ESA is big, their crystal complexes with Myr-2S-cPA demonstrate significantly different mode of binding of this LPL analogue. HSA binds three molecules of Myr-2S-cPA, whereas ESA only one. Moreover, none of the identified Myr-2S-cPA binding sites overlap in both albumins PMID: 27129297
    34. ghrelin binds to serum albumin and that this interaction impacts on the biological activity of the hormone. PMID: 27431015
    35. Higher levels of serum albumin are associated with a lower mortality rate in patients undergoing maintenance hemodialysis. PMID: 27542730
    36. results indicate that in addition to its role as a monitor of systemic inflammation, albumin may have a direct role in hepatocellular carcinoma growth inhibition, either through modulation of alpha-fetoprotein or through its actions on growth-controlling kinases PMID: 28486226
    37. These results provide an unprecedented view of how albumin interacts with Abeta and illustrate the potential of dark-state exchange saturation transfer NMR in mapping the interactions between amyloid-inhibitory proteins and amyloidogenic peptides. PMID: 28798235
    38. C-reactive protein-to-albumin ratio is a promising predictor of survival and recurrence in patients with rectal cancer treated by chemoradiotherapy followed by surgery. PMID: 28982904
    39. Lower serum albumin is associated with venous thromboembolic events in nephrotic syndrome. PMID: 28391310
    40. Data suggest that increased level of anti-Amadori-albumin autoantibodies may be used as a biomarker in disease diagnosis and its progression. PMID: 28192530
    41. Data indicate that repeated measurement after five hours showed a statistical significant difference for the fractional synthesis rate of fibrinogen but not for albumin. PMID: 28350862
    42. Data suggest that, unlike albumin with low FcRn-binding affinity, albumin with high FcRn-binding affinity (due to genetic variation/genetic engineering) is directed less to lysosomes and more to endosomes, suggestive of FcRn-directed albumin salvage from lysosomal degradation. (FcRn = neonatal Fc receptor) PMID: 28637874
    43. The mean albumin level for patients who developed heparin-induced thrombocytopenia-thrombosis (HITT) was significantly lower than that for patients who developed heparin-induced thrombocytopenia (HIT). PMID: 28289828
    44. Data suggest that posttranslational modifications of human serum albumin (HSA) typical of hyperhomocysteinemia (N and Shomocysteinylation) reduce binding affinity of catechins to HAS; the catechins used here were dietary flavonoids, epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG), and epigallocatechin gallate (EGCG). PMID: 26658763
    45. The studies suggest that impaired endocytosis of megalin/cubilin ligands, hemoglobin and albumin, rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients. PMID: 28356267
    46. Decreased serum albumin on admission is significantly associated with long-term all-cause mortality in hospital survivors of acute myocardial infarction. PMID: 27257851
    47. Intensity of systemic inflammation was assessed at all time points with C-reactive protein and albumin as prognostic covariates for overall survival in an extended Cox regression model.time-dependent effects are a prominent feature of intensity of systemic inflammation, a powerful prognostic biomarker for metastatic renal cell carcinoma. PMID: 28618965
    48. The presence of serum albumin in human eye tissues suggests its involvement in the metabolism, maintenance of tissue volume, and antioxidant reactions. PMID: 28361409
    49. study to dertermine ischemia modified albumin (IMA) level in inflammatory bowel diseases (IBD) and IBD subgroups, and to examine its relation with disease activity index; IMA levels in IBD were higher in comparison with the control group; IMA in IBD might be related with the pathogenesis of disease and correlated with the severity of the disease PMID: 26642816
    50. Serum ischemia-modified albumin was higher in type 2 DM patients than in control subjects and was higher in diabetic patients with diabetic peripheral neuropathy than in those without neuropathy. PMID: 27965983

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  • 相關疾病:
    Hyperthyroxinemia, familial dysalbuminemic (FDAH); Analbuminemia (ANALBA)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    ALB/AFP/VDB family
  • 組織特異性:
    Plasma.
  • 數據庫鏈接:

    HGNC: 399

    OMIM: 103600

    KEGG: hsa:213

    STRING: 9606.ENSP00000295897

    UniGene: Hs.418167



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