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Human gonadotropin-releasing hormone,GnRH ELISA Kit

  • 中文名稱:
    人促性腺激素釋放激素(GnRH)酶聯免疫試劑盒
  • 貨號:
    CSB-E06880h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人促性腺激素釋放激素(GnRH)酶聯免疫試劑盒(CSB-E06880h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的GNRH1含量。GNRH1是重要靶點。它是促性腺激素釋放激素基因。其背景上,在生殖內分泌調節中有關鍵作用。研究機制方面,主要是通過調控促性腺激素分泌,影響性腺發育和功能,對生殖系統疾病治療和生殖調控研究意義重大。試劑盒檢測范圍為2.5 pg/ml-100 pg/ml.,適用于生命科學領域的研究,例如探究生殖生理機制、評估內分泌干擾物的效應、分析動物模型生殖軸功能異常等場景。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    GNRH1 ELISA Kit; GNRH ELISA Kit; GRH ELISA Kit; LHRHProgonadoliberin-1 ELISA Kit; Progonadoliberin I) [Cleaved into: Gonadoliberin-1 ELISA Kit; Gonadoliberin I ELISA Kit; Gonadorelin ELISA Kit; Gonadotropin-releasing hormone I ELISA Kit; GnRH-I ELISA Kit; Luliberin I ELISA Kit; Luteinizing hormone-releasing hormone I ELISA Kit; LH-RH I); GnRH-associated peptide 1 ELISA Kit; GnRH-associated peptide I)] ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    2.5 pg/ml-100 pg/ml.
  • 靈敏度:
    0.625 pg/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

    Intra-assay Precision (Precision within an assay): CV%<15%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<15%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度:

    To assess the linearity of the assay, samples were spiked with high concentrations of human GnRH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

    Sample

    Serum(n=4)

    1:1

    Average %

    92

    Range %

    86-98

    1:2

    Average %

    97

    Range %

    92-106

    1:4

    Average %

    85

    Range %

    81-88

    1:8

    Average %

    89

    Range %

    83-96

  • 回收率:

    The recovery of human GnRH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    91

    87-98

    EDTA plasma (n=4)

    93

    88-99

  • 標準曲線:

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    100

    2.346

    2.489

    2.418

    2.378

    50

    1.725

    1.832

    1.779

    1.739

    25

    0.968

    1.050

    1.009

    0.969

    6.5

    0.352

    0.350

    0.351

    0.311

    2.5

    0.176

    0.179

    0.178

    0.138

    0

    0.039

    0.040

    0.040

     

  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
  • 基因功能參考文獻:
    1. High expression of LHRH is associated with ovarian cancer. PMID: 27793127
    2. GNRH (and GNRHR) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites. PMID: 26920257
    3. High LHRH expression is associated with sarcomas of bone and soft tissue. PMID: 27639272
    4. mutations in the region encoding the decapeptide associated with complete Idiopathic hypogonadotropic hypogonadism PMID: 26595427
    5. GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/MMP9 expression. PMID: 26660506
    6. analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells PMID: 26644469
    7. our results showed that GnRH participates in the self-renewal capacity and stemness maintenance of LCSLCs by upregulating the JNK signaling pathway, and GnRH may be useful as an alternative lung cancer stem-like cells therapy. PMID: 25955300
    8. Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review) PMID: 25916694
    9. Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG. PMID: 26308290
    10. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes PMID: 24002956
    11. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice. PMID: 25248098
    12. Data indicate that the gene expression pattern is profoundly different between human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist. PMID: 24603682
    13. GnRH agonists fail to increase Bax expression and do not potentiate the cytotoxic activity of docetaxel PMID: 24722580
    14. GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of aldosterone-producing adenoma. PMID: 24472523
    15. This review will summarize the current understanding of the mechanisms by which PACAP modulates gonadotrope function, with a focus on interactions with GnRH. PMID: 24095645
    16. Current research efforts aim to discover the mechanisms responsible for the decoding of the GnRH pulse signal by the gonadotrope. PMID: 24056171
    17. GPR101 is a critical requirement for GnRH-(1-5) transactivation of EGFR in Ishikawa cells. PMID: 24264576
    18. This review summarizes the mechanisms used by glial cells to control GnRH neuronal ativity and secretion. PMID: 23735672
    19. R31C GNRH1 is the only missense mutation that was identified in a CpG islet in nine congenital hypogonadotropic hypogonadism subjects from four unrelated families, giving evidence for a putative ''hot spot''. PMID: 23936060
    20. GnRHI, GnRHII and GnRH receptor expression correlated significantly with poor prognosis in breast cancer patients PMID: 23287110
    21. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. PMID: 23648337
    22. Olfactory ensheathing cells form a microenvironment for migrating GnRH-1 neurons during development. PMID: 23404564
    23. TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome PMID: 24010162
    24. Kisspeptin and GnRH pulse generation. PMID: 23550012
    25. Kisspeptin resets the GnRH pulse generator in men, but does not appear to do so in women PMID: 23550003
    26. Spontaneous GnRH release is detected in the median eminence of transgenic mice that produce diurnal variations in GnRH. PMID: 23077052
    27. The role of several class 1 cytokines in regulating GnRH neuronal development, GnRH secretion, and GnRH expression in this REVIEW. PMID: 22161498
    28. data demonstrate that GnRH transcription is repressed by AR via multiple sequences in GnRH-P, including three Oct-1 binding sites, and that this repression requires the complex interaction of several transcription factors PMID: 22074952
    29. molecular mechanisms involved in GnRH/GnRHR signaling at the maternal-fetal interface. [Review] PMID: 22024993
    30. Mutations in GNRH1 have been associated with both mild and severe forms of GnRH deficiency, and may work in combination with other gene mutations to produce GnRH-deficient phenotypes. PMID: 21722705
    31. [review] Existing evidence suggests that neural pathways originating in hindbrain and hypothalamic feeding nuclei transmit information concerning glucose availability to GnRH neurons, which integrate numerous physiological signals and metabolic cues. PMID: 21855365
    32. Data show that higher levels of GnRH IgM antibodies were detected in patients with IBS and dysmotility, but not organic GI diseases, compared with healthy controls. PMID: 21714833
    33. Assessment of CGB and GNRH1 expression level in cancer patients' blood may be useful for indicating metastatic spread of tumor cells. PMID: 21827674
    34. Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger postmenopausal women PMID: 21646369
    35. Deletion of the cell-specific enhancer region of GnRH implicates the GnRH promoter in mediating pubertal development and periodic reproductive cycling. PMID: 21368045
    36. Lactation is an important physiological model of the integration of energy balance and reproduction, as it involves activation of potent appetitive neuropeptide systems coupled to a profound inhibition of pulsatile GnRH/LH secretion--REVIEW PMID: 20727862
    37. A large literature dealing with various stressors that regulate gonadotrophin-releasing hormone secretion in a variety of species provides evidence that stress modulates GnRH secretion by activating the corticotrophin-releasing factor system--REVIEW PMID: 20727865
    38. The sources of glutamatergic inputs to the GnRH neurons are only just beginning to be examined and include the anteroventral periventricular nucleus as well as the possibility that GnRH neurons--REVIEW PMID: 20807514
    39. We then discuss possible neurobiological mechanisms underlying GnRH pulse generation, and conclude by proposing that kisspeptin neurons in the arcuate nucleus are key players--REVIEW PMID: 20951683
    40. homozygous inactivating mutations in the GNRH1 gene causing hypothalamic hypogonadotropic hypogonadism in patients were reported, validating definitively the pivotal role of GnRH in human pubertal development and reproduction--REVIEW PMID: 20887715
    41. GNRH1 mutations might cause congenital idiopathic (or isolated) hypogonadotropic hypogonadism (Review) PMID: 20389089
    42. The role of GnRH-GnRHR signaling at the maternal-fetal interface therefore appears to be limited to the regulation of trophoblast hCG production. PMID: 20400076
    43. Data describe the distribution and sex dimorphism of kisspeptin-immunoreactive elements in hypothalami, reveal contacts between kisspeptin-immunoreactive fibers and GnRH cells, and colocalize kisspeptins and neurokinin B in the infundibular nucleus. PMID: 20529119
    44. Metabolic signals are integrated at the levels of first-order neurons equipped with the proper receptors, ant that these neurons send their signals towards hypothalamic GnRH neurons which constitute the integrative element of this network. PMID: 20138117
    45. The major genes associated with GnRH-dependent pubertal disorders, are reviewed. PMID: 20188792
    46. Review: Using human GnRH deficiency as a paradigm and presenting original data from the screening of numerous candidate genes, we discuss the emerging model of patient-focused clinical genetic research. PMID: 20484732
    47. cadherin switching and p120(ctn) signaling as important targets of GnRH function and as novel mediators of invasiveness and tumor progression in ovarian cancer. PMID: 20118984
    48. data indicate that the promoter region between -992 and -795 contains elements both essential and sufficient for targeting gene expression to GnRH neurons PMID: 11875100
    49. Coupling of GnRH concentration and the GnRH receptor-activated gene program PMID: 12040003
    50. JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH. PMID: 12054733

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  • 相關疾?。?/div>
    Hypogonadotropic hypogonadism 12 with or without anosmia (HH12)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    GnRH family
  • 數據庫鏈接:

    HGNC: 4419

    OMIM: 152760

    KEGG: hsa:2796

    STRING: 9606.ENSP00000276414

    UniGene: Hs.82963



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