在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human epiregulin (EREG) ELISA kit

  • 中文名稱(chēng):
    人上皮調(diào)節(jié)蛋白(EREG)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-EL007779HU
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人上皮調(diào)節(jié)蛋白(EREG)酶聯(lián)免疫試劑盒(CSB-EL007779HU)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的EREG含量。EREG即表皮調(diào)節(jié)素,是表皮生長(zhǎng)因子家族成員。它可與EGFR結(jié)合激活下游信號(hào)通路,在細(xì)胞的增殖、分化及存活等方面起作用。研究發(fā)現(xiàn)其在多種腫瘤中異常表達(dá),與腫瘤的發(fā)生、發(fā)展、侵襲轉(zhuǎn)移等相關(guān),是潛在的腫瘤治療靶點(diǎn)。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL,適用于體外培養(yǎng)細(xì)胞分泌研究、疾病動(dòng)物模型體液檢測(cè)、腫瘤微環(huán)境分析等科研場(chǎng)景,為探究EREG在癌癥生物學(xué)、炎癥調(diào)控及再生醫(yī)學(xué)中的功能機(jī)制提供可靠工具本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名:
    Epiregulin ELISA Kit; EPR ELISA Kit; ER ELISA Kit; Ereg ELISA Kit; EREG_HUMAN ELISA Kit; Proepiregulin ELISA Kit
  • 縮寫(xiě):
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類(lèi)型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測(cè)范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Cancer
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human EREG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
     SampleSerum(n=4)
    1:1Average %86
    Range %84-89
    1:2Average %99
    Range %94-103
    1:4Average %92
    Range %90-95
    1:8Average %94
    Range %89-98
  • 回收率:
    The recovery of human EREG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9287-99
    EDTA plasma (n=4)8985-96
  • 標(biāo)準(zhǔn)曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.100 1.952 2.026 1.936
    5001.351 1.342 1.347 1.257
    2500.788 0.779 0.784 0.694
    1250.478 0.468 0.473 0.383
    62.50.290 0.282 0.286 0.196
    31.20.219 0.204 0.212 0.122
    15.60.156 0.151 0.154 0.064
    00.092 0.088 0.090  
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
  • 基因功能參考文獻(xiàn):
    1. in Caco-2 CFTR-shRNA cells, the EGFR ligand EREG is overexpressed due to an active IL-1beta autocrine loop that indirectly activates EGFR, constituting new signaling effectors for the CFTR signaling pathway, downstream of CFTR, Cl(-) , and IL-1beta. PMID: 29091309
    2. we showed that epidermal growth factor receptors (EGFR) were constitutively activated in metastatic lung subtypes of salivary adenoid cystic carcinoma cells, and that this activation was induced by autocrine expression of epiregulin PMID: 26958807
    3. Study shows how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. Results reveal how responses to different EGFR ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (RTK) signaling specificity. PMID: 28988771
    4. EREG and MMP-1 were found to be elevated in nasal polyp and uncinate tissues in patients with Chronic rhinosinusitis with nasal polyps. PMID: 28398769
    5. upregulation of EREG expression through promoter demethylation might be an important means of activating the EGFR pathway during the genesis of colorectal adenocarcinoma (CRC) and potentially other cancers. PMID: 27270421
    6. EREG and AREG are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site. PMID: 27272216
    7. three-dimensional structure of the EPR antibody (the 9E5(Fab) fragment) in the presence and absence of EPR PMID: 26627827
    8. Together, these studies lead to identification of a novel pathway involving EREG and MMP-1 that contributes to the formation of early stage breast cancer PMID: 26215578
    9. These results suggested that EREG is one of the molecules involved in glioma malignancy PMID: 24470554
    10. Data indicate that the effects of epiregulin (EREG) and V-ATPase (TCIRG1) single nucleotide polymorphism (SNP) on pulmonary tuberculosis susceptibility, to the extent that they exist, are dependent on gene-gene interactions in West African populations. PMID: 24898387
    11. Patients homozygous for the minor allele A of EREG rs12641042 had a significantly higher 3-year survival rate than patients with allele C (HR 0.48; P=0.034), but significance was lost in multivariable analysis PMID: 25203737
    12. Epiregulin is a transcriptional target of TSC2 (tuberin). PMID: 24748662
    13. Epiregulin promotes the proliferation of liver progenitor cells and DNA synthesis by hepatocytes and is upregulated in the serum of patients with liver injury. PMID: 24812054
    14. Plasma HGF and EREG levels are associated with resistance to treatment with anti-EGFR antibodies in KRAS wild-type patients with metastatic colorectal cancer. PMID: 24800946
    15. Data suggest that EREG (epiregulin), AREG (amphiregulin), and BTC (betacellulin) induced prostaglandin E2 production by induction of COX-2 (prostaglandin-endoperoxide synthase 2) through MAP kinase signaling in granulosa cells. PMID: 24092824
    16. In pre-treated K-ras wild-type status colorectal cancer, patients with high EREG gene expression appear to benefit more from cetuximab therapy compared with low expression. PMID: 24335920
    17. EREG may contribute to glioma progression under the control of IRE1a. PMID: 24330607
    18. keratinocyte hyperproliferation in cholesteatoma is promoted through overexpression of epiregulin by subepithelial fibroblasts via epithelial-mesenchymal interactions, which may play a crucial role in the pathogenesis of middle ear cholesteatoma PMID: 23826119
    19. Depletion of Epiregulin with shRNA inhibited SCAP proliferation. PMID: 23829318
    20. Data indicate that epiregulin (EREG) expression significantly correlated with KRAS expression or KRAS copy number in KRAS-mutant non-small-cell lung cancer (NSCLC) cell lines. PMID: 22964644
    21. EREG-AREG and NRG1, which are members of the epidermal growth factor (EGF) family, seem to modulate Bhecet's Disease susceptibility through main effects and gene-gene interactions PMID: 23625463
    22. we did not find a correlation between the presence of a K-ras mutation and the presence of Epiregulin and Amphiregulin in colon cancer tissue. PMID: 23885463
    23. Apical mistrafficking of EREG crystallizes an apical EGFR signaling complex that may be uncoupled from basolateral regulatory restraints leading to cell transformation. PMID: 23671122
    24. FBXL11 inhibited osteo/dentinogenic differentiation potential in MSC cells by associating with BCOR, then increasing histone K4/36 methylation in Epiregulin promoter to repress Epiregulin transcription. PMID: 23074094
    25. EREG gene expression was low in 7 out of 11 gastric cancer cells and this downregulation was mediated by aberrant CpG methylation of the EREG promoter. PMID: 22508389
    26. Epiregulin (EREG) variation is associated with susceptibility to tuberculosis. PMID: 22170233
    27. Data suggest that expression status of AR and EPI mRNAs might be evaluated as dynamic predictors of response in KRAS WT patients receiving any cetuximab-based therapy. PMID: 21161326
    28. It is suggested that follow-up of the expression of Ep can serve as a reliable early indication of the development of ovarian cancer. PMID: 21769422
    29. Blockade of epiregulin reduced the growth of hTERT-BJ cells and colony formation of hTERT-transformed fibroblasts. Moreover, inhibition of epiregulin function in immortal hTERT-BJ cells triggered a senescence program. PMID: 12702554
    30. Epiregulin might be a more important tumor growth regulator of malignant fibrous histiocytoma through autocrine or paracrine pathways, when compared with betacellulin. PMID: 15274392
    31. upregulation of the epiregulin and amphiregulin expression is part of the signal transduction pathway which leads to ovulation and luteinization in the human ovary PMID: 15474502
    32. findings demonstrated that PGE2 may mimic LH action at least in part by the activation of amphiregulin and epiregulin biosynthesis in human granulosa cells PMID: 16888076
    33. epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis PMID: 17429393
    34. 1st report of EREG expression in breast cancer (45.5% of breast cancers studied). It is preferentially expressed in breast tumors co-expressing HER2/HER4. PMID: 17962208
    35. Epiregulin played an autocrine role in the proliferation of corneal epithelial cells presumably through cross-induction with other EGF family members. PMID: 18079685
    36. hamartomatous TSC skin tumors are induced by paracrine factors released by two-hit cells in the dermis, and proliferation with mTOR activation of the overlying epidermis is an effect of epiregulin PMID: 18292222
    37. Increased epiregulin is associated with oral squamous cell carcinomas PMID: 18497965
    38. Epiregulin has a protective effect against apoptosis in the human corpus luteum. PMID: 18835871
    39. The regulatory mechanism of epiregulin expression in Ki-ras-transformed 267B1 prostate epithelial cells was studied. PMID: 18948081
    40. Epiregulin expression correlates with advanced disease, is EGFR dependent, and confers invasive properties on non-small cell lung cancer cells. PMID: 19138957

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Epiregulin]: Secreted, extracellular space.; [Proepiregulin]: Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3443

    OMIM: 602061

    KEGG: hsa:2069

    STRING: 9606.ENSP00000244869

    UniGene: Hs.115263



主站蜘蛛池模板: 亚洲中文字幕无码专区| 久久综合香蕉国产蜜臀av | 性欧美暴力猛交69hd| 亚洲国产精品一区第二页| 99精品国产一区二区| 久久天天躁狠狠躁夜夜躁2012| 亚洲人成无码网www动漫| 人妻精品人妻无码一区二区三区| 亚洲区日韩精品中文字幕| 日韩久久无码免费毛片软件 | 亚洲成av人片天堂网老年人| 色99久久久久高潮综合影院| 天天做天天爱夜夜夜爽毛片| 先锋影音xfyy5566男人资源| 日韩精品一区二区av在线| 国产又爽又大又黄a片| 成人动漫综合网| 性色欲情网站iwww| 久久无码高潮喷水抽搐| 尤物精品国产第一福利网站| 久久久www成人免费无遮挡大片 | 国产免费艾彩sm调教视频| 亚洲深深色噜噜狠狠爱网站| 国产在线码观看清码视频| 中文字幕亚洲一区二区三区| 精品无码三级在线观看视频| 麻豆国产尤物av尤物在线观看| 99999久久久久久亚洲| 欧美大片aaaaa免费观看| 国产精品www夜色视频| 亚洲综合另类小说色区| 亚洲欧美综合精品成人网站| 成人性做爰aaa片免费看不忠| 综合图片亚洲综合网站| 99久视频只有精品2019| 亚洲欧美色中文字幕在线| 精品人妻少妇一区二区三区在线| 国产又黄又爽又色的免费| 一本色道久久88精品综合| 国产午夜福利短视频| 亚洲欧美韩国综合色|