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  4. Human dihydropyrimidinase-like 3,DPYSL3 ELISA Kit

Human dihydropyrimidinase-like 3,DPYSL3 ELISA Kit

  • 中文名稱：
    人二氫嘧啶酶樣3(DPYSL3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E11790h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人二氫嘧啶酶樣3(DPYSL3)酶聯(lián)免疫試劑盒（CSB-E11790h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的DPYSL3含量。DPYSL3即二氫嘧啶酶樣蛋白3，它參與神經系統(tǒng)發(fā)育等過程，在軸突生長、神經導向和神經元遷移中起作用。研究顯示其表達異常與腫瘤等疾病相關，機制可能涉及調控細胞增殖、遷移和侵襲等信號通路，是潛在的疾病治療靶點。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于神經生物學研究、腫瘤微環(huán)境分析、藥物靶點篩選等科研場景，為探索DPYSL3在細胞信號傳導、病理模型建立及分子互作機制中的功能提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Collapsin response mediator protein 4 ELISA Kit; Collapsin response mediator protein 4 long ELISA Kit; CRMP 4 ELISA Kit; CRMP-4 ELISA Kit; CRMP4 ELISA Kit; Dihydropyrimidinase like 3 ELISA Kit; Dihydropyrimidinase related protein 3 ELISA Kit; Dihydropyrimidinase-related protein 3 ELISA Kit; DPYL3_HUMAN ELISA Kit; DPYSL3 ELISA Kit; DRP 3 ELISA Kit; DRP-3 ELISA Kit; DRP3 ELISA Kit; LCRMP ELISA Kit; TUC4 ELISA Kit; ULIP 1 ELISA Kit; ULIP ELISA Kit; ULIP-1 ELISA Kit; ULIP1 ELISA Kit; UNc 33 like phosphoprotein 1 ELISA Kit; Unc 33 like phosphoprotein ELISA Kit; Unc-33-like phosphoprotein 1 ELISA Kit
  • 縮寫：
    DPYSL3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.8 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human DPYSL in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 93
    Range % 89-94
    1:2 Average % 106
    Range % 103-109
    1:4 Average % 85
    Range % 81-89
    1:8 Average % 94
    Range % 90-98
  • 回收率：
    The recovery of human DPYSL spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 84 80-88
    EDTA plasma (n=4) 95 91-99
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 2.275 2.198 2.237 2.145
    1000 1.772 1.802 1.787 1.695
    500 1.308 1.300 1.304 1.212
    250 0.902 1.000 0.951 0.859
    125 0.645 0.656 0.651 0.559
    62.5 0.441 0.438 0.440 0.348
    31.25 0.303 0.310 0.307 0.215
    0 0.091 0.092 0.092 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
  • 基因功能參考文獻：
    1. Data indicate that CRMP4a and CRMP4b isoforms have opposite effects on cell proliferation, migration, and invasion in gastric cancer. CRMP4a expression was reduced in gastric carcinoma tissues and cell lines and seems to act as a tumor suppressor in gastric carcinoma. CRMP4b expression was higher in tumor tissue and cell lines. PMID: 27475326
    2. DPYSL3 expression levels inversely correlated with those of VEGF and FAK. Down-regulation of DPYSL3 expression in HCC tissues may serve as a predictive biomarker for HCC after curative resection. PMID: 25173447
    3. Expression status of DPYSL3 in gastric cancer tissues may represent a promising biomarker for the malignant behavior of GC. PMID: 25096402
    4. DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex PMID: 24339867
    5. structures provide further insight into the effects of medically relevant mutations of the DPYSL-3 gene encoding CRMP-4 and the putative enzymatic activities of CRMPs PMID: 24914979
    6. High collapsin response mediator protein 4 expression is associated with liver metastasis in pancreatic cancer. PMID: 22805864
    7. Downregulation of MYCN by small interfering RNA (siRNA) increased DPYSL3 levels, while upregulation of MYCN in non-MYCN NB cells decreased DPYSL3 levels. PMID: 24011394
    8. study found the association between the rs147541241 variant and amyotrophic lateral scerosis was limited to the French population PMID: 23568759
    9. Ulip1 was downregulated and HIF1a was upregulated in hypoxic neuroblastoma cells. PMID: 20977846
    10. CRMP4 is a key physiological substrate of GSK3 in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubules PMID: 21179545
    11. Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response. PMID: 20804502
    12. new function of CRMP4 as a metastasis-suppressor in lymph node metastasis of prostate cancer PMID: 20543870
    13. HUlip was expressed in late fetal and early postnatal brains in the neurons of the brain stem, basal ganglia/thalamus, and dentate gyrus of the hippocampus. HUlip expression was easily detected in tumor cells undergoing neuronal differentiation. [Ulip] PMID: 15933812

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  • 亞細胞定位：
    Cytoplasm. Cell projection, growth cone.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 組織特異性：
    Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
  • 數據庫鏈接：

    HGNC: 3015

    OMIM: 601168

    KEGG: hsa:1809

    STRING: 9606.ENSP00000343690

    UniGene: Hs.519659



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