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  4. Human cathepsin H (CTSH) ELISA kit

Human cathepsin H (CTSH) ELISA kit

  • 中文名稱：
    人組織蛋白酶H (CTSH)酶聯免疫試劑盒
  • 貨號：
    CSB-E13723h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人組織蛋白酶H (CTSH)酶聯免疫試劑盒（CSB-E13723h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的CTSH含量。CTSH即組織蛋白酶H，它屬于半胱氨酸蛋白酶家族。在人體生理功能維持上扮演重要角色。研究聚焦其在腫瘤發生發展中的作用機制，包括促進腫瘤細胞增殖、遷移和侵襲等，還探索其在神經系統疾病等領域的潛在病理機制，為相關疾病治療提供新方向。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，科研人員可利用該產品開展CTSH在腫瘤發生發展、免疫細胞功能調控、神經退行機制等領域的表達特征研究，也可用于藥物干預實驗中生物標志物的動態監測。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    ACC 4 ELISA Kit; ACC 5 ELISA Kit; ACC4 ELISA Kit; ACC5 ELISA Kit; aleurain ELISA Kit; CATH_HUMAN ELISA Kit; cathepsin B3 ELISA Kit; cathepsin BA ELISA Kit; Cathepsin H heavy chain ELISA Kit; Cathepsin H light chain ELISA Kit; Cathepsin H mini chain ELISA Kit; CPSB ELISA Kit; CTSH ELISA Kit; minichain ELISA Kit; N benzoylarginine beta naphthylamide hydrolase ELISA Kit; N-benzoylarginine-beta-naphthylamide hydrolase ELISA Kit; pro cathepsin H ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<10%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<15%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CTSH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 96    
    Range % 89-106    
    1:2 Average % 89    
    Range % 82-97    
    1:4 Average % 94    
    Range % 85-105    
    1:8 Average % 95    
    Range % 85-101    
  • 回收率：
    The recovery of human CTSH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 95 89-100    
    EDTA plasma (n=4) 95 87-105    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    20 2.142 2.099 2.121 1.934    
    10 1.765 1.798 1.782 1.595    
    5 1.264 1.295 1.280 1.093    
    2.5 0.789 0.811 0.800 0.613    
    1.25 0.604 0.621 0.613 0.426    
    0.625 0.422 0.436 0.429 0.242    
    0.312 0.302 0.299 0.301 0.114    
    0 0.186 0.187 0.187 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Important for the overall degradation of proteins in lysosomes.
  • 基因功能參考文獻：
    1. the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts). PMID: 28157489
    2. Especially, rs3825932 in CTSH has integrative functional evidence supporting the association with type 1 diabetes mellitus. PMID: 26429317
    3. p41 fragment is also shown to reduce the secretion of interleukin-12 (IL-12/p70) during the subsequent maturation of treated dendritic cells. PMID: 26960148
    4. In conclusion, CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to proliferative diabetic retinopathy and two-step progression of diabetic retinopathy on the ETDRS scale accordingly. PMID: 26245339
    5. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2. PMID: 25525168
    6. The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D PMID: 24982147
    7. CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength PMID: 23204516
    8. The processing of procathepsin H is an autocatalytic, multistep process proceeding from an inactive 41kDa pro-form, through a 30kDa intermediate form, to the 28kDa mature form. PMID: 22704610
    9. CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression. PMID: 21217776
    10. These data indicate that cathepsins B, L and S may act as cell-death mediators in in monocytic cells infected with ICP4 and Us3 deletion mutant herpes simplex virus type 1. PMID: 20881085
    11. involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes PMID: 12034564
    12. Cathepsin H could contribute to the transformation of LDL to an atherogenic moiety; the process might involve a self-sustaining amplifying circle. PMID: 12615673
    13. kinetic data on substrates hydrolysis and enzyme inhibition show the role of the mini-chain as a framework for transition state stabilization of free alpha-amino groups of substrates and as a structural barrier for endopeptidase-like substrate cleavage. PMID: 14515996
    14. AKR1B1 and CTSH may be good markers for prediction of sensitivity to certain drugs PMID: 14662023
    15. cathepsin H is involved in maturation of the biologically active surfactant associated protein B PMID: 14766755
    16. cathepsin H has a role in progression of colorectal cancer that is distinct from that of cathepsins B and L PMID: 15646835
    17. A general defect in napsin A or cathepsin H expression or activity was not the specific cause for abnormal surfactant accumulation in juvenile pulmonary alveolar proteinosis PMID: 18216060
    18. In contrast to cathepsin S, cathepsin H values did not correlate with markers of inflammation, indicating a specific role for cathepsin H in the pleural host response. PMID: 19404922

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  • 亞細胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 數據庫鏈接：

    HGNC: 2535

    OMIM: 116820

    KEGG: hsa:1512

    STRING: 9606.ENSP00000220166

    UniGene: Hs.148641



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