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  4. Human cardiac troponin T(cTn-T)ELISA Kit

Human cardiac troponin T(cTn-T)ELISA Kit

  • 中文名稱：
    人心肌肌鈣蛋白T(cTn-T)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13047h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人心肌肌鈣蛋白T(cTn-T)酶聯(lián)免疫試劑盒（CSB-E13047h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的TNNT1含量。TNNT1是重要的靶點。它是心肌肌鈣蛋白亞基，在心肌收縮調(diào)節(jié)中起關(guān)鍵作用。對它的研究機制主要聚焦于其與心肌疾病的關(guān)聯(lián)，探索其在疾病發(fā)生發(fā)展中的作用，有望為相關(guān)心肌疾病的診斷、治療及藥物研發(fā)提供方向。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，該產(chǎn)品采用預(yù)包被特異性抗體的96孔板結(jié)構(gòu)，配套標準品、檢測抗體及顯色試劑，操作流程標準化，支持科研領(lǐng)域中心血管疾病機制研究、藥物心臟毒性評估以及心肌損傷動物模型分析等應(yīng)用場景，為探索心肌病理生理過程提供高靈敏度的檢測工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ANM ELISA Kit; MGC104241 ELISA Kit; NEM5 ELISA Kit; Skeletal ELISA Kit; Slow ELISA Kit; slow skeletal muscle ELISA Kit; Slow skeletal muscle troponin T ELISA Kit; sTnT ELISA Kit; Tnnt1 ELISA Kit; TNNT1_HUMAN ELISA Kit; TNT ELISA Kit; TnTs ELISA Kit; Troponin T ELISA Kit; Troponin T slow skeletal muscle ELISA Kit; Troponin T type 1 (skeletal slow) ELISA Kit; troponin T1 skeletal slow ELISA Kit; Troponin T1, slow skeletal type ELISA Kit
  • 縮寫：
    TNNT1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human cTn-T in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %94
    Range %90-100
    1:2Average %90
    Range %85-99
    1:4Average %98
    Range %90-107
    1:8Average %92
    Range %85-100
  • 回收率：
    The recovery of human cTn-T spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9892-104
    EDTA plasma (n=4)9590-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.288 2.391 2.340 2.194
    51.447 1.508 1.478 1.332
    2.50.824 0.838 0.831 0.685
    1.250.525 0.547 0.536 0.390
    0.6250.316 0.329 0.323 0.177
    0.3120.264 0.273 0.269 0.123
    0.1560.225 0.234 0.230 0.084
    00.145 0.146 0.146 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能參考文獻：
    1. High TNNT1 expression is associated with breast cancer. PMID: 30031058
    2. This study describes the first TNNT1 mutation that transmits in an autosomal dominant fashion to cause nemaline myopathy. PMID: 29178646
    3. investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC, TnI and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca(2+) PMID: 28923663
    4. Data suggest that mutations in troponin C (TnC, A8V) and troponin T (TnT, delta14-TnT) found in patients with hypertrophic cardiomyopathy together fully stabilize the active M state of regulated actin (the actin-tropomyosin-troponin complex). PMID: 28530094
    5. pathogenesis of TNNT1 myopathies PMID: 27429059
    6. Copeptin and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI. PMID: 27903076
    7. TNNT1 genetic and epigenetic variations are associated with HDL-C levels and coronary artery disease. PMID: 26950807
    8. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. PMID: 26774798
    9. Nemaline body myopathy Palestinian patients were found to have a novel mutation in troponin T1. PMID: 26296490
    10. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants PMID: 24625749
    11. Biopsy-proven acute and viral myocarditis is associated with elevated concentrations of hs-TnT. PMID: 24781421
    12. Troponin T1 blood levels had a positive association with increased risk for hypertrophic cardiomyopathy. PMID: 24020864
    13. TNNT1 DNA methylation levels were positively correlated with mean HDL particle size, HDL-phospholipid, HDL-apolipoprotein AI, HDL-C and TNNT1 expression levels. PMID: 23244308
    14. Human slow skeletal troponin T (HSSTnT) isoforms, despite being homologues of cardiac TnT may display distinct functional properties in muscle regulation. PMID: 22977240
    15. analysis of parameters of oxygen-dependent metabolism of neutrophils by NBT test and levels of vWF antigen in the serum can be used for predicting the risk of unfavorable outcome in patients with ACS and normal troponin T PMID: 22448368
    16. In heart failure patients with normal ejection fraction, highly sensitive troponin T and heart fatty acid binding protein are elevated independent of coronary artery disease. PMID: 21729325
    17. baseline cTnT levels are higher in patients with MPI evidence of reversible myocardial ischaemia than those without reversible ischaemia PMID: 22239123
    18. carotid-femoral pulse wave and office pulse pressure are associated with minimally elevated hsTnT levels in the elderly PMID: 21784424
    19. the hypertrophic phenotype associated with the TnT mutations can be characterized by a significant increase in disorder of rigor cross-bridges. PMID: 21683708
    20. Elevated serum troponin T levels are associated with different conditions related to the severity of hypertrophic cardiomyopathy. PMID: 21111984
    21. Cardiac troponin T and creatine kinase have roles in infarct size and left ventricular function after acute myocardial infarction PMID: 21448949
    22. The occurrence of myocardial infarction is associated with elevated troponin T levels. PMID: 19916752
    23. Among athletees, faster runners demonstrate significantly stronger cardoac TnT releases and inflammation signs. PMID: 20380359
    24. troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population PMID: 20038417
    25. Troponin T may have a role in pulmonary embolism progeresion to death PMID: 19541721
    26. TNT is a biochemical marker of susceptibility to hypoxia in infants of type 1 diabetic mothers. PMID: 19690080
    27. Data suggest that inefficient incorporation into myofilament is responsible for the instability of mutant slow troponin T in Amish nemaline myopathy. PMID: 15665378
    28. Report adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease. PMID: 18579801
    29. slow TnT was encoded by two different transcripts in significantly different ratios in myotonic dystrophy type 1 and myotonic dystrophy type 2 muscles. PMID: 19326042

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  • 相關(guān)疾?。?/div>
    Nemaline myopathy 5 (NEM5)
  • 蛋白家族：
    Troponin T family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11948

    OMIM: 191041

    KEGG: hsa:7138

    STRING: 9606.ENSP00000467176

    UniGene: Hs.631558



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