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  4. Human a proliferation inducing ligand(APRIL)ELISA Kit

Human a proliferation inducing ligand(APRIL)ELISA Kit

  • 中文名稱：
    人增殖誘導配體(APRIL)酶聯免疫試劑盒
  • 貨號：
    CSB-E15012h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人增殖誘導配體(APRIL)酶聯免疫試劑盒（CSB-E15012h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液樣本中的TNFSF13含量。TNFSF13屬于腫瘤壞死因子配體超家族，在免疫系統中發揮關鍵作用。對其研究機制主要聚焦在它與免疫細胞的相互作用，以及在疾病如自身免疫病、癌癥中的表達異常。深入了解TNFSF13有望為相關疾病的診斷和治療提供新靶點與策略。試劑盒檢測范圍為0.78 ng/mL-50 ng/mL，適用于免疫調控機制研究、疾病模型生物標志物分析、藥物干預效果評估等科研場景，尤其適用于比較不同病理條件下 APRIL 在循環系統或泌尿系統中的表達差異，為探索其與 BAFF 受體信號通路的相互作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    A proliferation inducing ligand ELISA Kit; A proliferation-inducing ligand ELISA Kit; APRIL ELISA Kit; CD256 ELISA Kit; TALL-2 ELISA Kit; TALL2 ELISA Kit; TNF related death ligand ELISA Kit; TNF- and APOL-related leukocyte expressed ligand 2 ELISA Kit; TNF-related death ligand 1 ELISA Kit; TNF13_HUMAN ELISA Kit; TNFSF13 ELISA Kit; TRDL-1 ELISA Kit; TRDL1 ELISA Kit; Tumor necrosis factor (ligand) superfamily; member 13 ELISA Kit; Tumor necrosis factor ligand superfamily member 13 ELISA Kit; Tumor necrosis factor like protein ZTNF2 ELISA Kit; Tumor necrosis factor related death ligand 1 ELISA Kit; UNQ383/PRO715 ELISA Kit; ZTNF2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, urine
  • 檢測范圍：
    0.78 ng/mL-50 ng/mL
  • 靈敏度：
    0.195 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human APRIL in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 94  
    Range % 90-98  
    1:2 Average % 92  
    Range % 88-97  
    1:4 Average % 86  
    Range % 82-90  
    1:8 Average % 98  
    Range % 94-102  
  • 回收率：
    The recovery of human APRIL spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 104 100-108  
    EDTA plasma (n=4) 97 92-101  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    50 2.285 2.352 2.319 2.179  
    25 1.605 1.565 1.585 1.445  
    12.5 1.053 1.104 1.079 0.939  
    6.25 0.656 0.679 0.668 0.528  
    3.12 0.411 0.396 0.404 0.264  
    1.56 0.298 0.318 0.308 0.168  
    0.78 0.212 0.209 0.211 0.071  
    0 0.143 0.137 0.140    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
  • 基因功能參考文獻：
    1. TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population PMID: 28849223
    2. The results suggest that increased levels of BAFF and APRIL produced in the central nervous system may influence the development of anti-neutrophil cytoplasmic antibody-hypertrophic pachymeningitis. PMID: 28847534
    3. The genetic variations and gene expression level of TNFSF13 are associated with the susceptibility and severity of IgA nephropathy in a Han Chinese population. PMID: 28636766
    4. APRIL levels are associated with disease activity in human chronic graft-versus-host disease. PMID: 26992945
    5. APRIL but not BLyS promotes IL-10 production by CpG-activated B cells and enhances the regulatory role of B cells on T cells. PMID: 27372914
    6. BCMA has other contributors for ligands binding except DxL motif. The affinity of BCMA for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future PMID: 28260502
    7. APRIL transgenic mice infected by Helicobacter species may represent a novel animal model of gastric lymphomagenesis. PMID: 28460208
    8. ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes PMID: 27820817
    9. Results showed that chemokine-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression. PMID: 27923834
    10. This study showed that both BAFF and APRIL levels were increased in CSF of patients with anti-NMDAR encephalitis. PMID: 28284352
    11. The results demonstrated that rs11552708 of the APRIL gene is not associated with Systemic lupus erythematosus (SLE) susceptibility in Iranian children. Likewise, these findings suggest that APRIL antagonist could be a potential therapeutic target to control SLE in children. PMID: 27878683
    12. New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM. PMID: 27127303
    13. Urinary APRIL (uAPRIL) and BAFF (uBAFF) levels were raised significantly in AN. PMID: 27804111
    14. High expression of APRIL is associated with hepatocellular carcinoma. PMID: 28035399
    15. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population. PMID: 27569236
    16. Recombinant human APRIL (rhAPRIL) could rescue HCC cell proliferation inhibited by miR-383. PMID: 26385772
    17. high expression of APRIL in clear cell renal cell carcinoma was correlated with high Fuhrman nuclear grade, high pathologic stage, and poor overall and cancer-specific survival of the patients PMID: 26296917
    18. TNFSF13 and FDX1 have potential roles in IgAN in the Han Chinese population. This information may be useful in the development of early prognostics for IgAN. PMID: 26431901
    19. Did not find any positive association between TNFSF13 SNPs and the risk of IgA nephropathy after adjustment for age and sex, but did find a significant and strong correlation with relevant clinical pathological parameters. PMID: 26370181
    20. plasma level elevated in IgA nephropathy PMID: 26986150
    21. results indicate that analysis of serum concentrations of BAFF and APRIL potentially represents a useful tool for the assessment of AIHA disease activity and progression. PMID: 26243624
    22. Abnormal levels of BAFF/APRIL in pediatric acute lymphoblastic leukemia suggest that BAFF/APRIL are associated with the development and progression of this disease in children PMID: 26950089
    23. SNPs rs9514828 (BAFF), rs3803800 (APRIL) and rs4985726 (TACI) may be associated with the risk of development of B-cell chronic lymphocytic leukemia in a Polish population. PMID: 26268376
    24. Data show decrease of serum APRIL levels in diabetic patients with Type-1 Diabetes or Type-2 Diabetes suggesting suggest that APRIL can be considered as a potential modulating cytokine in the inflammatory process of diabetes. PMID: 26469782
    25. Surface APRIL is elevated in circulating myeloid cells in patients with rheumatoid arthritis, where it is highly correlated with disease activity. PMID: 25729037
    26. elevated serum levels in patients with Behcet's disease PMID: 25759827
    27. the elevated presence of APRIL and BLyS in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL-expressing B cells/plasma cells. PMID: 26150532
    28. Results show that APRIL was significantly up-regulated in gastric cancer and high levels of APRIL correlated with resistance to cisplatin through the activation of the canonical NF-kappaB pathway. PMID: 25612651
    29. APRIL could be a potential diagnosed marker to distinguish glottic malignant disease from glottic benign lesion, and it may play an important role in the development of glottic malignant disease. PMID: 24276470
    30. APRIL expression is correlated with malignant gastrointestinal stromal tumours phenotypes and it may serve as an unfavourable prognostic marker in patients with gastrointestinal stromal tumours PMID: 25393252
    31. High APRIL expression is associated with breast cancer. PMID: 25750171
    32. Data suggest that APRIL protein (a proliferation-inducing ligand) could be a potential biomarker for predicting difficult-to-treat cases of lupus nephritis. PMID: 23171638
    33. APRIL is increased in patients with active systemic lupus erythematosus. PMID: 24748505
    34. Enhanced APRIL levels are associated with acute lymphoblastic leukemia. PMID: 25582383
    35. A high APRIL serum level was significantly associated with decreased progression-free survival in follicular lymphoma patients. PMID: 25146008
    36. APRIL may participate in the formation of seropositive rheumatoid arthritis. PMID: 24898359
    37. Our results suggest that an elevated level of BAFF/APRIL drives the maturation of B cells, subsequently leading to IgA2 class switching, and possibly to the development of interstitial lung disease in patients with mixed connective tissue disease. PMID: 24252051
    38. BAFF and APRIL as well as their cognate receptors (BCMA, TACI) correlate with glioma grade. (Meta-analysis) PMID: 24376672
    39. Show a novel method to obtain soluble human APRIL in Escherichia coli using the elastin-like polypeptide and SUMO (ELP-SUMO) tags. PMID: 24412409
    40. The levels of APRIL correlate with the progression of childhood ALL, which may provide certain clues for monitoring ALL clinically. PMID: 23887020
    41. Levels of serum APRIL are useful biomarkers for disease progression and disease activity in multiple myeloma. PMID: 24141333
    42. APRIL depletion induces cell cycle arrest and apoptosis partly through blocking noncanonical TGF-beta1/ERK. PMID: 23867993
    43. Increased serum expression of APRIL correlates with the development of colorectal neoplasms. PMID: 23792260
    44. Although neither serum BAFF nor APRIL correlated with disease activity in the overall population, elevated serum BAFF and reduced APRIL may be markers of renal and CNS disease in systemic lupus erythematosus patients PMID: 23846230
    45. Our findings indicate TNFSF13 is a prognostic factor in non-small cell lung cancer PMID: 24436270
    46. Both APRIL and B-cell-activating factor (BAFF) regulate spinal cord injury-induced autoimmunity through B-cell maturation antigen (BMCA). PMID: 23088438
    47. increased serum levels of BLyS and APRIL in BD patients supports the notion of a critical role for B cell activation factors in BD, particularly in terms of uveitis and disease activity. PMID: 22752534
    48. Using a capture sequencing strategy, we discovered the B-cell relevant genes IRF8, EBF1, and TNFSF13 as novel targets for IGH deregulation. PMID: 23775715
    49. APRIL protein is upregulated in the serum of patients with opsoclonus-myoclonus syndrome. PMID: 23324534
    50. High serum APRIL is associated with multiple myeloma. PMID: 23768867

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Tumor necrosis factor family
  • 組織特異性：
    Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
  • 數據庫鏈接：

    HGNC: 11928

    OMIM: 604472

    KEGG: hsa:8741

    STRING: 9606.ENSP00000343505

    UniGene: Hs.54673



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