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  4. Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit

Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit

  • 中文名稱：
    人酪氨酸蛋白激酶受體UFO(AXL)酶聯免疫試劑盒
  • 貨號：
    CSB-EL002476HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人酪氨酸蛋白激酶受體UFO(AXL)酶聯免疫試劑盒（CSB-EL002476HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的AXL含量。AXL是一種受體酪氨酸激酶，異常表達與癌癥患者的臨床病理特征和預后不良有關。研究顯示，AXL在腫瘤中參與增殖、遷移、侵襲等過程，與腫瘤不良預后及耐藥密切相關。其研究機制涉及轉錄因子ETS1的調控，以及AXL抑制劑在癌癥治療中的潛力。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，靈敏度為7.81 pg/mL。適用于科研領域中對AXL蛋白表達水平的精準評估，如癌癥發生機制研究、纖維化疾病模型構建或炎癥相關信號通路探索，其兼容的液體樣本（血清/血漿）及組織勻漿樣本可滿足不同實驗場景需求，為體外研究AXL蛋白功能及其調控機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human AXL in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 93  
    Range % 84-95  
    1:2 Average % 92  
    Range % 85-99  
    1:4 Average % 90  
    Range % 86-95  
    1:8 Average % 95  
    Range % 85-100  
  • 回收率：
    The recovery of human AXL spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 94 91-99  
    EDTA plasma (n=4) 95 87-99  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    2000 2.232 2.257 2.245 2.075  
    1000 1.462 1.520 1.491 1.321  
    500 0.859 0.871 0.865 0.695  
    250 0.527 0.554 0.541 0.371  
    125 0.325 0.335 0.330 0.160  
    62.5 0.277 0.259 0.268 0.098  
    31.25 0.221 0.233 0.227 0.057  
    0 0.165 0.175 0.170 　  
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展：
    AXL是一種受體酪氨酸激酶，已被發現在多種癌癥中起重要作用。最新的研究表明，AXL的過度表達可能導致腫瘤細胞的增殖、侵襲和耐藥性增加，因此成為治療癌癥的重要靶點之一。此外，最新研究還發現，AXL還參與了免疫反應和神經元細胞的發育等生理過程。
  • 功能：
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.; (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.; (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
  • 相關疾?。?/div>
    AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily
  • 組織特異性：
    Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
  • 數據庫鏈接：

    HGNC: 905

    OMIM: 109135

    KEGG: hsa:558

    STRING: 9606.ENSP00000301178

    UniGene: Hs.590970



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