在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Tumor necrosis factor receptor superfamily member 18(TNFRSF18) ELISA kit

  • 中文名稱:
    人腫瘤壞死因子受體超家族成員18(TNFRSF18)酶聯免疫試劑盒
  • 貨號:
    CSB-EL023975HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人腫瘤壞死因子受體超家族成員18(TNFRSF18)酶聯免疫試劑盒(CSB-EL023975HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的TNFRSF18含量。TNFRSF18是重要靶點,屬于腫瘤壞死因子受體超家族。其背景上與免疫調節密切相關。研究機制方面,它可參與T細胞共刺激過程,調節免疫細胞活性和功能,在腫瘤免疫治療、自身免疫病等研究中,是探索調控免疫反應的關鍵方向。試劑盒檢測范圍為0.156 ng/ml- 10ng/ml,科研人員可將其應用于免疫調控機制探索、藥物干預效果評估或疾病模型構建等基礎研究,例如通過檢測不同實驗處理條件下生物樣本中 TNFRSF18 的表達動態,揭示其在免疫檢查點調控中的潛在作用。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Activation inducible TNFR family receptor ELISA Kit; Activation-inducible TNFR family receptor ELISA Kit; AITR ELISA Kit; CD357 ELISA Kit; GITR ELISA Kit; GITR D ELISA Kit; GITR-D ELISA Kit; GITRD ELISA Kit; Glucocorticoid induced TNFR related protein ELISA Kit; glucocorticoid-induced tnf receptor ligand ELISA Kit; glucocorticoid-induced tnf receptors ligand ELISA Kit; Glucocorticoid-induced TNFR-related protein ELISA Kit; TNF receptor superfamily activation inducible protein ELISA Kit; TNFRSF 18 ELISA Kit; TNFRSF18 ELISA Kit; TNR18_HUMAN ELISA Kit; Tumor necrosis factor receptor superfamily member 18 ELISA Kit; Tumor necrosis factor receptor superfamily member 18 precursor ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.156 ng/ml- 10ng/ml
  • 靈敏度:
    0.039 ng/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
  • 基因功能參考文獻:
    1. HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR PMID: 28101786
    2. a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner PMID: 28542810
    3. Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients. PMID: 25293713
    4. GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation. PMID: 25973846
    5. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells. PMID: 25961057
    6. Data may suggest a key role of regulatory GITR+CD25 low/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients. PMID: 25256257
    7. results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP. PMID: 25445616
    8. these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function. PMID: 23929911
    9. Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS. PMID: 23935647
    10. GITR acts as a potential tumor suppressor in MM. PMID: 23785514
    11. Data indicate that the mRNAs of CTLA-4 and GITR genes were expressed at lower levels in CVID patients compared to control group. PMID: 23432692
    12. GITR is pathologically expressed on Treg cells in systemic lupus erythematosus. PMID: 22516990
    13. Liver tumor Tregs up-regulate the expression of glucocorticoid-induced tumor necrosis factor receptor compared with Tregs in tumor-free liver tissue and blood. PMID: 22911397
    14. Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis. PMID: 22309286
    15. The regulatory SNPs identified in this study will provide useful information for understanding the relevance of sequence polymorphisms in populations of different background and may serve as a basis to study parasite susceptibility in association studies PMID: 21445534
    16. GITRL may contribute to disease pathophysiology and resistance to direct and Rituximab-induced NK reactivity in CLL PMID: 22064350
    17. GITR, which transmits a signal that abrogates regulatory T cell functions, was elevated in early rheumatoid arthritis. PMID: 21670968
    18. DCs transfected with mRNA encoding a humanized anti-CTLA-4 mAb and mRNA encoding a soluble human GITR fusion protein enhance the induction of anti-tumor CTLs in response to DCs. PMID: 22028176
    19. Findings suggest that GITR-expression of TILs is associated with cancer progression. PMID: 21694467
    20. Although GITR transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR ligand interactions are not required for development of Th2-mediated resistance or pathology. PMID: 21705620
    21. Data indicate that CD4(+) CD25(low) GITR(+) cells represent a low percentage of the CD4(+) T-cell population (0.32-1.74%) and are mostly memory cells. PMID: 21557210
    22. study concludes, the rs3753348 C/G SNP in the GITR is associated with Hashimoto's disease prognosis and expression on T(reg) and T(eff) cells PMID: 21592113
    23. GITR rapidly recruits TNF receptor-associated factor 2 (TRAF2) in a ligand-dependent manner; data indicate that the cytoplasmic domain of GITR contains a single TRAF binding site where acidic residues 202/203 and 211-213 are critical for this interaction. PMID: 15944293
    24. Since regulatory T-cells are localized in the vicinity of GITRL-expressing cells in atopic dermatitis skin, the GITR/GITRL interaction may serve to perpetuate the inflammation locally. PMID: 16955181
    25. This protein has been shown to stimulate T cell-mediated antitumor immunity in mice, and now in a human tumor cell line. PMID: 17360848
    26. These data suggest that, despite abnormal GITR expression during HIV infection, GITR triggering enhances HIV-specific CD4(+) T cell cytokine expression and protects HIV-specific CD4(+) T cells from apoptosis. PMID: 17538882
    27. although GITR is an activation marker for NK cells similar to that for T cells, GITR serves as a negative regulator for NK cell activation PMID: 18230609
    28. CD4(+)CD25(+) effector memory T-cells expressing CD134 and GITR seem to play a role in disease mechanisms, as suggested by their close association with disease activity and their participation in the inflammatory process in Wegener's granulomatosis. PMID: 18723571
    29. mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta. PMID: 18924213
    30. Data show that in humans GITRL expression subverts NK cell immunosurveillance of AML. PMID: 19155305
    31. mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in T regulatory cells of children with diabetes compared to the control patients PMID: 19547759

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
  • 數據庫鏈接:

    HGNC: 11914

    OMIM: 603905

    KEGG: hsa:8784

    STRING: 9606.ENSP00000328207

    UniGene: Hs.212680



主站蜘蛛池模板: 老子午夜精品无码| 潮喷大喷水系列无码久久精品| 欧美人与动牲交欧美精品| 日韩国产综合精选| 人妻丰满熟妇av无码区| 精品久久久久久人妻无码中文字幕 | 337p日本欧洲亚洲大胆裸体艺术| 国产成人免费无码视频在线观看| 人与禽性视频77777| 夜夜精品无码一区二区三区| 国产av久久久久精东av| 成人午夜亚洲精品无码区| 国产xxx69麻豆国语对白| 99久久婷婷国产综合精品| 亚洲国产天堂久久久久久| 一本加勒比hezyo中文无码| 国产精品久久久久久人妻精品| 日日碰狠狠躁久久躁综合小说| 亚洲成在人线av| 樱花草在线社区www中国中文| 专干熟肥老妇人视频在线看| 国产超级va在线观看视频| 日本饥渴人妻欲求不满| 国产爆乳无码视频在线观看3| 欧美video性欧美熟妇| 亚洲日本乱码一区二区产线一∨| 久久精品国产一区二区电影| 丰满多毛的大隂户视频| 色偷拍 自怕 亚洲 10p| 亚洲高请码在线精品av| 337p日本欧洲亚洲大胆精筑| 国内a∨免费播放| 亚洲欧美中文字幕5发布| 亚在线第一国产州精品99| 高潮潮喷奶水飞溅视频无码| 国产精品麻豆欧美日韩ww| 狠狠色噜噜狼狼狼色综合久| 国产xxxx色视频在线观看| 国产高清色高清在线观看| 久久精品午夜福利| 中文精品久久久久人妻|