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  4. Human Trypsin-2(PRSS2) ELISA kit

Human Trypsin-2(PRSS2) ELISA kit

  • 中文名稱：
    人胰蛋白酶原Ⅱ(Try-Ⅱ)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09623h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人胰蛋白酶原Ⅱ(Try-Ⅱ)酶聯(lián)免疫試劑盒（CSB-E09623h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的Try含量。試劑盒檢測(cè)范圍為0.78 ng/ml-50 ng/ml，靈敏度為0.19 ng/ml。為研究胰腺外分泌功能、探索相關(guān)疾病分子機(jī)制、評(píng)估實(shí)驗(yàn)性治療干預(yù)效果等科研領(lǐng)域提供可靠工具，適用于基礎(chǔ)醫(yī)學(xué)研究、生物標(biāo)志物篩選及藥物開發(fā)等非診斷性科研場(chǎng)景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說(shuō)明書。
  • 別名：
    Anionic trypsinogen ELISA Kit; EC 3.4.21.4 ELISA Kit; MGC111183 ELISA Kit; MGC120174 ELISA Kit; Protease serine 2 preproprotein ELISA Kit; Protease; serine; 2 (trypsin 2) ELISA Kit; Protease; serine; 2 ELISA Kit; Protease; serine; 2; preproprotein ELISA Kit; Prss2 ELISA Kit; Serine protease 2 ELISA Kit; TRY2 ELISA Kit; TRY2_HUMAN ELISA Kit; TRY8 ELISA Kit; TRYP2 ELISA Kit; Trypsin 2 ELISA Kit; Trypsin II ELISA Kit; Trypsin-2 ELISA Kit; Trypsinogen 2 ELISA Kit
  • 縮寫：
    Try
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.78 ng/ml-50 ng/ml.
  • 靈敏度：
    0.39 ng/m
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(ng/ml)

    5.828

    6.052

    6.250

    5.828

    5.970

    6.314

    SD

    0.034

    0.039

    0.045

    0.038

    0.049

    0.055

    CV(%)

    4.043

    4.519

    5.102

    4.518

    5.731

    6.194

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human Trypsin-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    92

    Range %

    87-98

    1:2

    Average %

    98

    Range %

    93-104

    1:4

    Average %

    84

    Range %

    82-88

    1:8

    Average %

    90

    Range %

    85-97

  • 回收率：

    The recovery of human Trypsin-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    95

    89-99

    EDTA plasma (n=4)

    96

    90-102

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    50

    2.432

    2.389

    2.411

    2.265

    25

    1.822

    1.831

    1.827

    1.681

    12.5

    1.276

    1.281

    1.279

    1.133

    6.25

    0.819

    0.804

    0.812

    0.666

    3.12

    0.431

    0.434

    0.433

    0.287

    1.56

    0.234

    0.243

    0.239

    0.093

    0.78

    0.189

    0.184

    0.187

    0.041

    0

    0.149

    0.142

    0.146

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    降鈣素原（Try）是一種由甲狀腺C細(xì)胞合成的肽類激素，它參與調(diào)節(jié)鈣離子代謝和降低血鈣水平的生理過(guò)程。近期研究發(fā)現(xiàn)，Try在乳腺癌、甲狀腺癌、骨髓瘤等惡性腫瘤的發(fā)生和發(fā)展中扮演著重要角色。此外，Try還與乳腺癌的分期和預(yù)后相關(guān)，具有很好的診斷和預(yù)測(cè)價(jià)值。
  • 功能：
    In the ileum, may be involved in defensin processing, including DEFA5.
  • 基因功能參考文獻(xiàn)：
    1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis PMID: 26110235
    2. PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. PMID: 25253127
    3. Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. PMID: 25916077
    4. trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. PMID: 22909050
    5. Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
    6. Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
    7. Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
    8. results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21792081
    9. A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
    10. Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
    11. there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
    12. Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
    13. Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. PMID: 19752771
    14. Results indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
    15. High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
    16. G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis PMID: 16699518
    17. Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
    18. Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9. PMID: 18062964
    19. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. PMID: 18362849
    20. A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
    21. primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1 PMID: 18986305
    22. The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
    23. G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465

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  • 亞細(xì)胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Peptidase S1 family
  • 組織特異性：
    Expressed in Paneth cells, at the base of small intestinal crypts.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9483

    OMIM: 601564

    KEGG: hsa:5645

    UniGene: Hs.449281



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